Publications
Current Concepts in Normal and Defective Angiogenesis: Implications for Systemic Sclerosis Current Rheumatology Reports 2007, 9:173–179 -Mary Jo Mulligan-Kehoe, PhD, and Michael Simons, MD Section of Cardiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues Matrix Biology xx (2007) xxx–xxx(in press) -Roger Lawrence a,1,2, Tomio Yabe b,1,3, Sassan HajMohammadi c, John Rhodes c, Melissa McNeely d, Jian Liu e, Edward D. Lamperti f, Paul A. Toselli f, Miroslaw Lech a, Patricia G. Spear d, Robert D. Rosenberg a, Nicholas W. Shworak c,- a Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States b Department Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States c Department of Medicine , Dartmouth Medical School, Hanover, NH 03756, United States d Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL , United States e Department of Medicinal Chemistry and Natural Products, University of North Carolina, Chapel Hill, NC, United States f Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, United States
Genetic Evidence Supporting Caveolae Microdomain Regulation of Calcium Entry in Endothelial Cells*THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 282, NO. 22, pp. 16631–16643, June 1, 2007 -Takahisa Murata‡, Michelle I. Lin‡, Radu V. Stan§, Phillip Michael Bauer‡, Jun Yu‡, and William C. Sessa‡1 From the ‡Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 and the §Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756
‘Caveolae’ Review Series - J. Cell. Mol. Med. Vol 11, No 1, 2007 pp. 4-5 - Radu V Stan - Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
Protection Against Myocardial Ischemia–Reperfusion Injury by the Angiogenic Masterswitch Protein PR 39 Gene Therapy:The Roles of HIF1 Stabilization and FGFR1 SignalingANTIOXIDANTS & REDOX SIGNALING Volume 9, Number 4, 2007 DOI: 10.1089/ars.2006.1501; -EBO D. DE MUINCK 1, NORBERT NAGY 2, DANIELA TIRZIU 1, MASAHIRO MURAKAMI 1, NARASIMMAN GURUSAMY 2, SHYAMAL K. GOSWAMI 2, SATISH GHATPANDE 3, RICHARD M. ENGELMAN 2, MICHAEL SIMONS 1, and DIPAK K. DAS 2,1 1Angiogenesis Research Center, Dartmouth Medical School, Hanover, New Hampshire. 2Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut. 3Department of Pediatrics, Yale University, New Haven, Connecticut.
Synectin-dependent gene expression in endothelial cellsPhysiol Genomics 27: 380–390, 2006 -Anthony A. Lanahan,1* Thomas W. Chittenden,1* Eileen Mulvihill,2 Kimberly Smith,3 Stephen Schwartz,2 and Michael Simons1 1Angiogenesis Research Center and Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; and Departments of 2Pathology and 3Pharmacology, University of Washington School of Medicine, Seattle, Washington
Arteriogenesis: Noninvasive Quantification with Multi–DetectorRow CT Angiography and Three-dimensional Volume Rendering in Rodents Radiology: Volume 240: Number 3—September 2006 - Zhen W. Zhuang, MD, Ling Gao, ME. Masahiro Murakami, MD, PhD, Justin D. Pearlman, MD, ME, PhD., Terry J. Sackett, BS, Michael Simons, MD, Ebo D. de Muinck, MD, PhD Angiogenesis Research Center (Z.W.Z., L.G., M.M., J.D.P., M.S., E.D.d.M.) and Departments of Radiology (Z.W.Z., J.D.P., T.J.S.), Medicine (Z.W.Z., L.G., M.M., J.D.P., M.S.,E.D.d.M.), and Physiology (E.D.d.M.), Dartmouth Medical School, Borwell Research Building HB 7700, 1 Medical Center Dr, Lebanon, NH 03756.
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels The Journal of Clinical Investigation, Volume 116, Number 5, May 2006 - Jun Yu,1 Sonia Bergaya,1 Takahisa Murata,1 Ilkay F. Alp,1 Michael P. Bauer,1 Michelle I. Lin,1 Marek Drab,2 Teymuras V. Kurzchalia,2 Radu V. Stan,3 and William C. Sessa1 1Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. 2Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany. 3Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA.
Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner Circulation Research June 9, 2006 - Eugene Tkachenko,* Arye Elfenbein,* Daniela Tirziu, Michael Simons Angiogenesis Research Center, Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, NH.
Endocytosis pathways in endothelium: how many?Am J Physiol Lung Cell Mol Physiol 290: L806–L808, 2006 - Radu V. Stan Departments of Pathology and Immunology and Microbiology, Angiogenesis Research Center, Dartmouth Medical School, Lebanon, New Hampshire
Therapeutic Angiogenesis Section D, Chapter 154, IV Therapy - 1Michael Simons and 2Mark J. Post 1The Angiogenesis Research Center, Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 2Department of Physiology and Biomedical Technology, University of Maastricht, Maastricht, The Netherlands
Humoral and Cellular Factors Responsible for Coronary Collateral Formation Am J Cardiol 2006;98:1194 –1197 - Jonathan A. Sherman, MD a,b, Amy Hall, BS b, David J. Malenka, MD a, Ebo D. De Muinck, MD, PhD a,b, and Michael Simons, MD a,b,*aSection of Cardiology and the bAngiogenesis Research Center, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire.
Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation Am J Physiol Regul Integr Comp Physiol 290: R494–R500, 2006 - Mark J. Post,1,3 Kaori Sato,2 Masahiro Murakami,1 Jialin Bao,2 Daniela Tirziu,1 Justin D. Pearlman,1 and Michael Simons1 1Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, New Hampshire; 2Beth Israel Deaconess Medical Center, Boston, Massachusetts; and 3Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Binding of internalized receptors to the PDZ domain of GIPCsynectin recruits myosin VI to endocytic vesicles PNAS August 22, 2006 vol. 103 no. 34 12735–12740 - Samia N. Naccache*, Tama Hasson*†, and Arie Horowitz‡ *Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093;†College of Letters and Science, Undergraduate Research CenterCenter for Academic and Research Excellence, University of California,Los Angeles, CA 90095; and ‡Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Lebanon, NH 03756
Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries Am J Physiol Heart Circ Physiol 291: H2692–H2697, 2006 - L. Mandinov,1 K. L. Moodie,2 A. Mandinova,1 Z. Zhuang,2 F. Redican,2 D. Baklanov,2 V. Lindner,1 T. Maciag,1,† M. Simons,2 and E. D. de Muinck1 1Maine Medical Center Research Institute, Maine Medical Center, Scarborough, Maine; and 2Section of Cardiology, Angiogenesis Research Center, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire
A PDZ-binding Motif as a Critical Determinant of Rho Guanine Exchange Factor Function and Cell Phenotype Molecular Biology of the Cell Vol. 17, 1880–1887, April 2006 - Miaoliang Liu and Arie Horowitz Angiogenesis Research Centre and Section of Cardiology, Dartmouth Medical School, Lebanon, NH 03756
High-Resolution Quantitative Computed Tomography Demonstrating Selective Enhancement of Medium-Size Collaterals by Placental Growth Factor-1 in the Mouse Ischemic Hindlimb Circulation May 23, 2006 - Weiming Li, PhD; Weiqun Shen, PhD; Robert Gill, BS; Angela Corbly, CVT; Bonita Jones, RVT; Rama Belagaje, PhD; Yuke Zhang, MA; Shaoqing Tang, PhD; Yan Chen, MA; Yan Zhai, MA; Guoming Wang, MA; Asavari Wagle, MA; Kwan Hui, PhD; Michael Westmore, PhD; Jeffrey Hanson, BA; Yun-Fei Chen, PhD; Michael Simons, MD; JaiPal Singh, PhD Eli Lilly and Co, Indianapolis, Ind, and the Angiogenesis Research Center (M.S.), Dartmouth Medical School, Lebanon, NH.
Impact of Mouse Strain Differences in Innate Hindlimb Collateral Vasculature Arterioscler Thromb Vasc Biol. March 2006 - Armin Helisch, Shawn Wagner, Nadeem Khan, Mary Drinane, Swen Wolfram, Matthias Heil, Tibor Ziegelhoeffer, Ulrike Brandt, Justin D. Pearlman, Harold M. Swartz, Wolfgang Schaper Department of Experimental Cardiology (A.H., S.W., S.W., M.H., T.Z., U.B., W.S.), Max-Planck-Institute for Physiological & Clinical Research, Bad Nauheim, Germany; Angiogenesis Research Center & Section of Cardiology (A.H., M.D., U.B., J.D.P.), Dartmouth Medical School, Lebanon, NH; and EPR Center for Viable Biological Systems (N.K., H.M.S.), Dartmouth Medical School, Hanover, NH.
The Anti-angiogenic Activity of rPAI-123 Inhibits Fibroblast Growth Factor-2 Functions* The Journal of Biological Chemistry VOL. 281, NO. 44, pp. 33336–33344, November 3, 2006 - Mary Drinane, Jannine Walsh, Jessica Mollmark, Michael Simons, and Mary Jo Mulligan-Kehoe Departments of Surgery, Vascular Section, Medicine, Cardiology Section, and Pharmacology and Toxicology and theAngiogenesis Research Center, Dartmouth Medical School, Lebanon, New Hampshire 03756
Plasminogen and plasmin activity in patients with coronary artery disease Journal of Thrombosis and Haemostasis, (2006)4: 1288–1295 - M. C. DRINANE,*+ J . A. SHERMAN,+ A. E . HALL,+ M. SIMONS,+ and M. J . MULLIGAN-KEHOE*Department of Surgery, Vascular Section; +Angiogenesis Research Center, Dartmouth Medical School, Lebanon; Department of Medicine, Cardiology Section; and §Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA
Progress and prospects: Cell based regenerative therapy for cardiovascular disease Gene Therapy (2006) 13, 659–671 - ED de Muinck1, C Thompson2 and M Simons3 1Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; 2Department of Medicine, Angiogenesis Research Center and Section of Cardiology, Lebanon, NH, USA and 3Department of Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
Selective Regulation of Arterial Branching Morphogenesis by Synectin Developmental Cell 10, 783–795, June, 2006 - Thomas W. Chittenden,1,5,7 Filip Claes,2,6,7 Anthony A. Lanahan,1,5 Monica Autiero,2,6 Robert T. Palac,1,5 Eugene V. Tkachenko,1,5 Arye Elfenbein,1,5 Carmen Ruiz de Almodovar,2,6 Eduard Dedkov,3 Robert Tomanek,3 Weiming Li,4 Michael Westmore,4 JaiPal Singh,4 Arie Horowitz,1,5 Mary Jo Mulligan-Kehoe,1,5 Karen L. Moodie,1,5 Zhen W. Zhuang,1,5 Peter Carmeliet,2,6 and Michael Simons1,5,* 1Angiogenesis Research Center Section of Cardiology Departments of Medicine, Surgery, and Pharmacology and Toxicology Dartmouth Medical School Hanover, New Hampshire 03755 2Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium 3Department of Anatomy and Cell Biology University of Iowa Iowa City, Iowa 52242 4 Eli Lilly and Company Indianapolis, Indiana 46285
Flying kites on slippery slopes at Keystone - Symposium on Lipid Rafts and Cell Function - EMBO reports VOL 7 | NO 11 | 2006 - Satvajit Mayor1,Antonella Viola2,Radu V. Stan3 & Miguel A. del Pozo4+ 1National Centre for Biological Science (NCBS), Bangalore, India, 2Venetian Institute ofMolecular Medicine and Istituto Clinico Humanitas,Rozzano, Italy, 3Dartmouth Medical School, Lebanon,New Hampshire, USA, and 4Centro Nacional de Investigaciones Cardiovasculares (CNIC),Madrid, Spain
Transcriptional Profiling in Coronary Artery Disease Indications for Novel Markers of Coronary Collateralization Circulation October 24, 2006 - Thomas W. Chittenden, PhD; Jonathan A. Sherman, MD; Fei Xiong, MEng; Amy E. Hall, BS; Anthony A. Lanahan, PhD; Jennifer M. Taylor, PhD; Hangjun Duan, PhD; Justin D. Pearlman, MD, PhD; Jason H. Moore, PhD; Stephen M. Schwartz, MD, PhD; Michael Simons, MD Angiogenesis Research Center (T.W.C., J.A.S., A.E.H., A.L., J.P., M.S.), Section of Cardiology, Departments of Medicine (T.W.C., J.A.S., A.E.H., A.A.L., J.D.P., M.S.), Pharmacology and Toxicology (M.S.), and Radiology (J.D.P.), and Norris Cotton Cancer Center, Department of Genetics (J.H.M.), Dartmouth Medical School, Hanover, NH; Bioinformatics Programme, Department of Statistics (T.W.C., J.A.S.), and Wellcome Trust Centre for Human Genetics (J.M.T.), University of Oxford, Oxford, UK; Department of Computer Science (F.X., J.D.P.), Dartmouth College, Hanover, NH; and Department of Pathology (H.D., S.M.S.), University of Washington, Seattle.
Comparison of Transendocardial and Retrograde Coronary Venous Intramyocardial Catheter Delivery Systems in Healthy and Infarcted Pigs Catheterization and Cardiovascular Interventions 68:416–423 (2006) - D.V. Baklanov,1 MD, PhD, K.M. Moodie,1 DVM, F.E. McCarthy,1 E. Mandrusov,2 PhD, J. Chiu,2 MS, G. Aswonge,2 PhD, J. Cheng,2 PhD, M. Chow,2 MS, M. Simons,1 MD, and E.D. de Muinck1* MD, PhD 1Angiogenesis Research Center, Dartmouth Medical School, Hanover, NH 2Guidant Corp., Santa Clara, CA
Postmarket Surveillance for Drug-Eluting Coronary Stents: A Comprehensive Approach Circulation February 14, 2006 - Donald S. Baim, MD; Roxana Mehran, MD; Dean J. Kereiakes, MD; Thomas P. Gross, MD, MPH; Michael Simons, MD; David Malenka, MD; Aaron V. Kaplan, MD Cardiology Section, Brigham and Women’s Hospital, Boston, Mass (D.S.B.); Cardiovascular Research Foundation and Columbia University, New York, NY (R.M.); Heart Center/Lindner Center at the Christ Hospital, Cincinnati, Ohio (D.J.K.); Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Md (T.P.G.); and Cardiology Section, Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, NH (M.S., D.M., A.V.K.).
c-NGR: A Novel Homing Sequence for CD13/APN Targeted Molecular Imaging of Murine Cardiac Angiogenesis In Vivo Arterioscler. Thromb. Vasc. Biol. 2006;26;2681-2687; - Post and Ebo D. de Muinck Cleutjens, Adriaan Duijvestijn, Mirjam B. Smeets, Dominique P.V. de Kleijn, Mark J. Bianca H.G.J. Schrans-Stassen, Abdelkader Bennaghmouch, Leo Hofstra, Jack P.M. Alexandra Buehler, Marc A.M.J. van Zandvoort, Bram J. Stelt, Tilman M. Hackeng, CARIM (A.B., M.A.M.J.Z., B.J.S., T.M.H., B.H.G.J.S.-S., A.B., L.H., J.P.M.C., A.D., M.J.P.), University of Maastricht, Maastricht, The Netherlands; Cardiology (M.B.S., D.P.V.d.K.), University Hospital Utrecht, The Netherlands; Angiogenesis Research Center (E.D.d.M.), Dartmouth Medical School, Hanover, NH.
Continuous Endothelial Cell Activation Increases Angiogenesis: Evidence for the Direct Role of Endothelium Linking Angiogenesis and Inflammation - J Vasc Res 2006;43:193–204 - Gangaraju Rajashekhar a, b Antje Willuweit e Carolyn E. Patterson a, b, c Peichuan Sun a, b Andreas Hilbig e Georg Breier f Armin Helisch d Matthias Clauss a, b. - a Department of Cellular and Integrative Physiology, and b Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, c Roudebush VA Medical Center, Indianapolis, Ind. d Dartmouth-Hitchcock Medical Center, Lebanon, N.H. , USA; e Max-Planck-Institute, Bad Nauheim , and f Institut für Pathologie, Universitätsklinikum Carl Gustav Carus, Dresden , Germany
Delayed Arteriogenesis in Hypercholesterolemic Mice Circulation October 18, 2005 - Daniela Tirziu, PhD; Karen L. Moodie, DVM; Zhen W. Zhuang, MD; Katie Singer, RALAT; Armin Helisch, MD; Jeff F. Dunn, PhD; Weiming Li, PhD; Jaipal Singh, PhD; Michael Simons, MD Angiogenesis Research Center, Section of Cardiology (D.T., K.L.M., Z.W.Z., K.S., A.H., M.S.), Departments of Medicine (D.T., K.L.M., Z.W.Z., K.S., A.H., M.S.), Pharmacology & Toxicology (M.S.), and Radiology (J.F.D.), Dartmouth Medical School, Lebanon, NH, and Eli Lilly & Co, Indianapolis, Ind (W.L., J.S.).
Synthesis of Anticoagulantly Active Heparan Sulfate Proteoglycans by Glomerular Epithelial Cells Involves Multiple 3-O-Sulfotransferase Isoforms and a Limiting Precursor Pool* - THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 280, NO. 45, pp. 38059–38070, November 11, 2005 - Eric P. Girardin‡1, Sassan HajMohammadi§, Be´ atrice Birmele‡, Armin Helisch§, Nicholas W. Shworak§, and Ariane I. de Agostini¶ From the ‡Department of Pediatrics, and the ¶Department of Obstetric and Gynecology, University Hospital of Geneva, CH-1211 Geneva 14, Switzerland and the §Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03756
Structure of caveolae - doi:10.1016/j.bbamcr.2005.08.008 - Radu V Stan - Angiogenesis Research Center, Department of Pathology, Department of Microbiology and Immunology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Angiogenesis, Arteriogenesis, and Diabetes Paradigm Reassessed?* JACC Vol. 46, No. 5, 2005 Editorial Comment September 6, 2005:835–7 - Michael Simons, MD, FACC Angiogenesis Research Center, Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Angiogenesis in the human heart: Gene and cell therapy Angiogenesis (2005) - Daniela Tirziu & Michael Simons Angiogenesis Research Center and Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
Angiogenesis: Where Do We Stand Now? Circulation March 29, 2005 - Michael Simons, MD Angiogenesis Research Center and Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve PNAS August 2, 2005 vol. 102 no. 31 11003 2005 Jun Yu*, Ebo D. deMuinck†, Zhenwu Zhuang†, Mary Drinane†, Katalin Kauser‡, Gabor M. Rubanyi‡, Hu Sheng Qian‡, Takahisa Murata*, Bruno Escalante§, and William C. Sessa*¶ *Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536; †Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756; ‡Gene Therapy Department, Berlex Biosciences, Richmond, CA 94806; and §Department of Molecular Biomedicine, Centro de Investigacio´ n y de Estudios Avanzados del Instituto Politecnico Nacional, 07360 Mexico D.F., Mexico
HykGene: a hybrid approach for selecting marker genes forphenotype classification using microarray gene expression data Advance Access publication December 7, 2004 - Yuhang Wang1, Fillia S. Makedon1, James C. Ford2 and Justin Pearlman 2,3 1Department of Computer Science, Dartmouth College, 6211 Sudikoff Laboratory, Hanover, NH 03755-3510, USA, 2Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, 1 Rope Ferry Road, Hanover, NH 03755-1404, USA and 3Department of Radiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
The functions of plasminogen activator inhibitor-1: Do we have all the pieces of PAI? Thrombosis Research (2005) - Mary Jo Mulligan-Kehoe Gary N. Schwartz, Leo R. Zacharski Department of Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA, Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
PKC Activates eNOS and Increases Arterial Blood Flow In Vivo Circulation Research September 2, 2005 - Chohreh Partovian, Zhenwu Zhuang, Karen Moodie, Michelle Lin, Noriyuki Ouchi, William C. Sessa, Kenneth Walsh, Michael Simons Angiogenesis Research Center and Section of Cardiology (C.P., Z.Z., K.M., M.S.), Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH; the Molecular Cardiology/Whitaker Cardiovascular Institute (N.O., K.W.), Boston University School of Medicine, Mass; and the Department of Pharmacology and Molecular Cardiobiology Program (M.L., W.C.S.), Yale University School of Medicine, New Haven, Conn.
Collateral Artery Growth (Arteriogenesis) After Experimental Arterial Occlusion Is Impaired in Mice Lacking CC-Chemokine Receptor-2 Circulation Research March 19, 2004 - Matthias Heil,* Tibor Ziegelhoeffer,* Shawn Wagner, Borja Fernández, Armin Helisch,Sandra Martin, Silvia Tribulova, William A. Kuziel, Georg Bachmann, Wolfgang Schaper From the Department of Experimental Cardiology (M.H., T.Z., S.W., B.F., A.H., S.M., S.T., W.S.), Max-Planck-Institute for Physiological and Clinical Research, Bad Nauheim, Germany; Protein Design Labs, Inc. (W.A.K.), Fremont, Calif; Kerckhoff-Clinic (G.B.), Bad Nauheim, Germany.
Role of Angiogenesis in Cardiovascular Disease A Critical Appraisal Circulation September 20, 2005 - Rohit Khurana, MD, PhD; Michael Simons, MD; John F. Martin, FRCP; Ian C. Zachary, PhD BHF Laboratories, Department of Medicine, University College London, London, UK (R.K., J.F.M., I.C.Z.), and Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, NH (M.S.).
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and Angiogenesis - PNAS 2005;102;204-209; originally published online Dec 22, 2004; - Philip M. Bauer, Jun Yu, Yan Chen, Reed Hickey, Pascal N. Bernatchez, Robin Looft-Wilson, Yan Huang, Frank Giordano, Radu V. Stan, and William C. Sessa - *Departments of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, and †Medicine and Cardiovasculate Gene Therapy Program, Yale University School of Medicine, New Haven, CT 06536; and ‡Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756
Caveolin-1 Interacts Directly with Dynamin-2 - J. Mol. Biol. (2005) 348, 491–501 - Qing Yao1, Jing Chen1, Hong Cao1, James D. Orth1 J. Michael McCaffery2, Radu-Virgil Stan3 and Mark A. McNiven1* - 1Center for Basic Research in Digestive Diseases, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905 USA. 2 Integrated Imaging Center Department of Biology, Johns Hopkins University, Baltimore MD 21218, USA . 3 Department of Cellular and Molecular Medicine, University of California at San Diego La Jolla, CA 92093, USA
Calling on Reserves Granulocyte Colony Stimulating Growth Factor in Cardiac Repair Circulation November 15, 2005 - Ebo D. de Muinck, MD, PhD; Michael Simons, MD Angiogenesis Research Center, Section of Cardiology (E.D.d.M., M.S.), and the Departments of Medicine (E.D.d.M., M.S.), Physiology (E.D.d.M.), and Pharmacology and Toxicology (M.S.), Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Live 3D Echo Guidance of Catheter-Based Endomyocardial Injection Catheterization and Cardiovascular Interventions 65:340–345 (2005) - Dmitri V. Baklanov, MD, PhD, Ebo D. de Muinck, MD, PhD, Michael Simons, MD, Karen L. Moodie, DVM, Brenda E. Arbuckle, RDCS, Craig A. Thompson, MD, and Robert T. Palac,* MD Department of Medicine, Section of Cardiology, Dartmouth-Hitchcock Medical Center and Dartmouth Medical School, Hanover, New Hampshire.
Growth factor-induced therapeutic angiogenesis in the heart: protein therapy Cardiovascular Research 65 (2005) 649– 655 - Brian H. Annexa,a, Michael Simons b, Division of Cardiology, Department of Medicine, Durham Veterans Administration and Duke University Medical Center, Durham, NC, USA bSection of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Bone Marrow–Derived Cells Do Not Incorporate Into the Adult Growing Vasculature Circulation Research February 6, 2004 - Tibor Ziegelhoeffer, Borja Fernandez, Sawa Kostin, Matthias Heil, Robert Voswinckel, Armin Helisch, Wolfgang Schaper From Max Planck-Institut for Clinical & Physiological Research (T.Z., B.F., S.K., M.H., A.H., W.S.), Bad Nauheim, Germany, and Department of Internal Medicine (R.V.), University Hospital Giessen, Giessen, Germany.
Time-of-Flight Quantitative Measurements of Blood Flow in Mouse Hindlimbs Journal of Magnetic Resonance Imaging 19:468–474 (2004) - Shawn Wagner, PhD,1* Armin Helisch, MD,1 Georg Bachmann, MD,2 and Wolfgang Schaper, PhD, MD1 1Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Bad Nauheim, Germany. 2Department of Radiology, Kerckhoff Klinik, Bad Nauheim, Germany.
Magnetic resonance angiography of collateral vessels in a murine femoral artery ligation model NMR Biomed. 2004;17:21–27 - Shawn Wagner,1* Armin Helisch,1 Tibor Ziegelhoeffer,1 Georg Bachmann2 and Wolfgang Schaper1 1Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Benekestrasse 2, 61231 Bad Nauheim, Germany 2Department of Radiology, Kerckhoff Klinik, Benekestrasse 12, 61231 Bad Nauheim, Germany
Post–Market Approval Surveillance A Call for a More Integrated and Comprehensive Approach Circulation June 29, 2004 - Roxana Mehran, MD; Martin B. Leon, MD; David A. Feigal, MD; David Jefferys, MD; Michael Simons, MD; Nicholas Chronos, MD; Thomas J. Fogarty, MD;Richard E. Kuntz, MD, MSc; Donald S. Baim, MD; Aaron V. Kaplan, MD From the Lenox Hill Heart and Vascular Institute, New York, NY (R.M., M.B.L.); Devices Sector, Medical Devices Agency-United Kingdom (D.J.); Cardiology Section, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH (A.V.K., M.S.); American Cardiovascular Research Institute (N.C.); Department of Surgery, Stanford University, Stanford, Calif (T.J.F.); and Department of Medicine, Brigham and Women’s Hospital, Boston, Mass (R.E.K., D.S.B.). Dr Feigal is the former Director of the Center for Devices and Radiologic Health, Food and Drug Administration–USA.
An Adaptive Approach for Image Subtraction Conf Proc IEEE Eng Med Biol Soc 2004; 3:1818-20. - Zhifeng Wang1, Yurong Xu1, James Ford1, Fillia S. Makedon1, Zhenwu Zhuang2, Ling Gao2, Justin D. Pearlman2+1 1Department of Computer Science, Dartmouth College, Hanover NH 03755, USA 2 Advanced Imaging Center, Dartmouth Hitchcock Medical Center, Lebanon NH 03756, USA
Medical Device Development From Prototype to Regulatory Approval Circulation June 29, 2004 - Aaron V. Kaplan, MD; Donald S. Baim, MD; John J. Smith, MD, JD; David A. Feigal, MD; Michael Simons, MD; David Jefferys, MD; Thomas J. Fogarty, MD; Richard E. Kuntz, MD, MSc; Martin B. Leon, MD From the Cardiology Section, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH (A.V.K., M.S.);Department of Medicine, Brigham and Women’s Hospital, Boston, Mass (D.S.B., R.E.K.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (J.J.S.); Devices Sector, Medical Devices Agency-United Kingdom (D.J.); Department of Surgery, Stanford University, Stanford, Calif (T.J.F.); and Lenox Hill Heart and Vascular Institute, New York, NY (M.B.L.). Dr Feigal is the former Director of the Center for Devices and Radiologic Health, Food and Drug Administration–USA.
Thromboxane A2 Receptor Agonists Antagonize the Proangiogenic Effects of Fibroblast Growth Factor-2 Role of Receptor Internalization, Thrombospondin-1, and αv§3 Circulation Research April 2, 2004 - Anthony W. Ashton, Yan Cheng, Armin Helisch, J. Anthony Ware Departments of Medicine (Cardiology) and Molecular Pharmacology (A.W.A, A.H., J.A.W.), the Albert Einstein College of Medicine, Yeshiva University, Bronx, NY; and Center for Experimental Therapeutics (Y.C.), University of Pennsylvania, Philadelphia, Pa
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis Volume 10-Number 3-March 2004- Nature Medicine - Jehangir S. Wadia1,2, Radu V Stan 2, & Steve F Dowdy 1,2 - 1,Howard Hughes Medical Institute and 2, Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA
Integrative signaling in angiogenesis Molecular and Cellular Biochemistry 264: 99–102, 2004 - Michael Simons Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Cα in endothelial cells Cellular Signalling 16 (2004) 951–957 - Chohreh Partovian, Michael Simons Department of Medicine, Angiogenesis Research Center and Section of Cardiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Vascular Gene Expression in Nonneoplastic and Malignant Brain - American Journal of Pathology, Vol. 165, No. 2, August 2004 - Stephen L. Madden,* Brian P. Cook,* Mariana Nacht,*William D. Weber,* Michelle R. Callahan,* Yide Jiang,* Michael R. Dufault,* Xiaoming Zhang,* Wen Zhang,* Jennifer Walter-Yohrling,* Cecile Rouleau,* Viatcheslav R. Akmaev,* Clarence J. Wang,* Xiaohong Cao,* Thia B. St. Martin,* Bruce L. Roberts,* Beverly A. Teicher,* Katherine W. Klinger,* Radu-Virgil Stan,† Brenden Lucey,‡ Eleanor B. Carson-Walter,¶ John Laterra,‡§ and Kevin A. Walter¶ From Genzyme Oncology,* Framingham, Massachusetts; the Department of Cellular and Molecular Medicine,† University of California–San Diego, La Jolla, California; the Department of Neurology, Neuroscience, and Oncology,‡ Johns Hopkins University, Baltimore, Maryland; the Kennedy Krieger Institute,§ Baltimore, Maryland; the Department of Neurosurgery,¶ University of Pittsburgh, Pittsburgh, Pennsylvania; and the Brain Tumor Center, Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms Molecular Biology of the Cell Vol. 15, 3615–3630, August 2004 - Radu V. Stan,*†‡ Eugene Tkachenko,§ and Ingrid R. Niesman* *Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093-0651; and †Departments of Pathology, and of Microbiology and Immunology, and §Angiogenesis Research Center and Section of Cardiology, Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756
Novel Double Contrast MRI Technique for Intramyocardial Detection of Percutaneously Transplanted Autologous Cells Magnetic Resonance in Medicine 52:1438–1442 (2004) - Dmitri V. Baklanov, Ebo D. Demuinck, Craig A. Thompson, and Justin D. Pearlman Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, New Hampshire
Role of TGF-β1 and JNK signaling in capillary tube patterning Am J Physiol Cell Physiol 287: C1012–C1022, 2004 - Kiflai Bein, Elizabeth T. Odell-Fiddler, and Mary Drinane Angiogenesis Research Center, Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth College, Lebanon, New Hampshire 03756
Re-evaluating therapeutic neovascularization Journal of Molecular and Cellular Cardiology 00 (2003) - E.D. de Muinck a,b, M. Simons a,c, a Section of Cardiology, Department of Medicine, Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA b Section of Cardiology, Department of Physiology, Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA c Section of Cardiology, Department of Pharmacology and Toxicology, Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase The Journal of Cell Biology Volume 166, Number 7, 2004 - Keisuke Kamimura, 1,2 John M. Rhodes, 3 Ryu Ueda, 4 Melissa McNeely, 5 Deepak Shukla, 5 Koji Kimata, 2 Patricia G. Spear, 5 Nicholas W. Shworak, 3 and Hiroshi Nakato 1 -1 Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455 - 2 Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480-1195, Japan - 3 Section of Cardiology and Angiogenesis Research Center, Department of Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 - 4 Invertebrate Genetics Laboratory, Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan - 5 Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia Circulation October 19, 2004 - Rohit Khurana, MD; Zhenwu Zhuang, MD; Shalini Bhardwaj; Masahiro Murakami, MD, PhD; Ebo De Muinck, MD, PhD; Seppo Yla-Herttuala, MD; Napoleone Ferrara, MD; John F. Martin, FRCP; Ian Zachary, MD; Michael Simons, MD Centre for Cardiovascular Biology and Medicine (R.K., J.M., I.Z.), Department of Medicine, University College, London, UK; the Section of Cardiology (R.K., Z.Z., M.M., E.D.M., M.S.), Departments of Medicine and of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, NH; the Department of Biotechnology and Molecular Medicine (S.B., S.Y.-H.), A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland; and the Department of Molecular Oncology (N.F.), Genentech, Inc, South San Francisco, Calif.
Automated migration analysis based on cell texture: method & reliability BMC Cell Biology 2005 - Jianfeng Qin†1,2, Thomas W Chittenden 3,4, Ling Gao 2 and Justin D Pearlman*†1,2 1Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA, 2Dartmouth Advanced Imaging Center, Dartmouth-Hitchcock Medical Center, One Medical Drive, Lebanon, NH, 03756, USA, 3Angiogenesis Research Center, Dartmouth-Hitchcock Medical Center, One Medical Drive, Lebanon, NH, 03756, USA and 4Dartmouth Medical School, Hanover, NH, 03755, USA
Angiogenic modulators in valve development and disease: does valvular disease recapitulate developmental signaling pathways? - Current Opinion in Cardiology 2004, 19:140–146 - Nicholas W. Shworak Section of Cardiology and Angiogenesis Research Center, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
Syndecans - New Kids on the Signaling Block Circulation Research March 18, 2005 - Eugene Tkachenko, John M. Rhodes, Michael Simons Angiogenesis Research Center, Section of Cardiology, and Departments of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, N.H.
Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway Journal of Cell Science 117, 3189-3199 Published by The Company of Biologists 2004 - Eugene Tkachenko1, Esther Lutgens1, Radu-Virgil Stan2 and Michael Simons1,* 1Angiogenesis Research Center and Section of Cardiology, Department of Medicine and Department of Pharmacology and Toxicology, and 2Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
HykGene: A Hybrid Approach for Selecting Marker Genes for Phenotype Classification using Microarray Gene Expression Data Bioinformatics Advance Access published December 7, 2004 - Yuhang Wang a, Fillia Makedon a, James Ford a, Justin Pearlman b - aDepartment of Computer Science, Dartmouth College, Hanover, NH 03755 bDepartments of Medicine and Radiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH 03755
PR39 Inhibits Apoptosis in Hypoxic Endothelial Cells Role of Inhibitor Apoptosis Protein-2 Circulation April 6, 2004 - Jiaping Wu, MD; Cherie Parungo, MD*; Guifu Wu, MD, PhD*; Peter M. Kang, MD; Roger J. Laham, MD; Frank W. Sellke, MD; Michael Simons, MD; Jian Li, MD, PhD Angiogenesis Research Center, Divisions of Cardiology (J.W., C.P., G.W., P.M.K., R.J.L., J.L.) and Cardiothoracic Surgery (F.W.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, and Section of Cardiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH (M.S.).
Characterization of synectin expression and promoter activity Gene 342 (2004) 29–34 - Yufeng Zhang, Thomas Chittenden, Michael Simons Angiogenesis Research Center and Section of Cardiology, Departments of Medicine and Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, One Medical Center drive, Lebanon, NH 03756, United States