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Henry N. Higgs, PhD

Professor of Biochemistry


Lafayette College, BA 1987U. Washington, PHD 1996

Molecular and Cellular Biology Graduate Programs

Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755

Professional Interests:

Microvilli cover the surface of circulating blood lymphocytes. Lymphocytes use these finger-like projections to segregate adhesion receptors, as certain receptors localize to microvilli while others are excluded from them. Adhesion receptor segregation is crucial because cells use these receptors sequentially when moving from the bloodsteam to specific tissues. Little is known about the architecture of microvilli, nor about their relationship to similar structures from other cells. My lab will identify protein components crucial to microvillar structure, test how mutation of these proteins affect microvillar structure and function, and characterize how these proteins function biochemically and biophysically.

Selected Publications:


Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites.
Ji WK, Hatch AL, Merrill RA, Strack S, Higgs HN
Elife. 2015 Nov 26;4:e11553. doi: 10.7554/eLife.11553. Epub 2015 Nov 26.
PMID: 26609810

Cell type-dependent mechanisms for formin-mediated assembly of filopodia.
Young LE, Heimsath EG, Higgs HN
Mol Biol Cell. 2015 Dec 15;26(25):4646-59. doi: 10.1091/mbc.E15-09-0626. Epub 2015 Oct 7.
PMID: 26446836

Assembly and turnover of short actin filaments by the formin INF2 and profilin.
Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN
J Biol Chem. 2015 Sep 11;290(37):22494-506. doi: 10.1074/jbc.M115.670166. Epub 2015 Jun 29.
PMID: 26124273

The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.
Gauvin TJ, Young LE, Higgs HN
Mol Biol Cell. 2015 Feb 1;26(3):467-77. doi: 10.1091/mbc.E14-07-1247. Epub 2014 Nov 26.
PMID: 25428984

Novel roles for actin in mitochondrial fission.
Hatch AL, Gurel PS, Higgs HN
J Cell Sci. 2014 Nov 1;127(Pt 21):4549-60. doi: 10.1242/jcs.153791. Epub 2014 Sep 12.
PMID: 25217628

Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.
Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF
Chem Commun (Camb). 2014 Oct 18;50(81):12037-9. doi: 10.1039/c4cc04399e.
PMID: 25170530

Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.
Gurel PS, Hatch AL, Higgs HN
Curr Biol. 2014 Jul 21;24(14):R660-72. doi: 10.1016/j.cub.2014.05.033.
PMID: 25050967

A role for myosin II in mammalian mitochondrial fission.
Korobova F, Gauvin TJ, Higgs HN
Curr Biol. 2014 Feb 17;24(4):409-14. doi: 10.1016/j.cub.2013.12.032. Epub 2014 Jan 30.
PMID: 24485837

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.
Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD
PLoS One. 2014;9(1):e85090. doi: 10.1371/journal.pone.0085090. Epub 2014 Jan 13.
PMID: 24454796

INF2-mediated severing through actin filament encirclement and disruption.
Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN
Curr Biol. 2014 Jan 20;24(2):156-64. doi: 10.1016/j.cub.2013.12.018. Epub 2014 Jan 9.
PMID: 24412206