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Duane A. Compton, Ph.D.

Title(s):
Interim Dean of the Medical School
Professor of Biochemistry
Interim Dean, Geisel School of Medicine at Dartmouth

Department(s):
Biochemistry

Education:
U. Oklahoma, BS 1984
U. Texas, PHD 1988

Programs:
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs

Websites:
http://geiselmed.dartmouth.edu/compton/

Contact Information:

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755


Professional Interests:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.

Biography:

Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Mentoring Information:

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.


Selected Publications:

 

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA
DNA damage response during mitosis induces whole chromosome mis-segregation.
Cancer Discov 2014 Aug 8;
PMID: 25107667

Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D
The mitotic origin of chromosomal instability.
Curr Biol 2014 Feb 17; 24(4):R148-9
PMID: 24556433

Kabeche L, Compton DA
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Nature 2013 Oct 3; 502(7469):110-3
PMID: 24013174

Orr B, Compton DA
A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.
Front Oncol 2013; 3:164
PMID: 23825799

Hood EA, Kettenbach AN, Gerber SA, Compton DA
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.
Mol Biol Cell 2012 Jun; 23(12):2264-74
PMID: 22535524

Bakhoum SF, Compton DA
Chromosomal instability and cancer: a complex relationship with therapeutic potential.
J Clin Invest 2012 Apr 2; 122(4):1138-43
PMID: 22466654

Kabeche L, Compton DA
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
Curr Biol 2012 Apr 10; 22(7):638-44
PMID: 22405866

Bakhoum SF, Compton DA
Kinetochores and disease: keeping microtubule dynamics in check!
Curr Opin Cell Biol 2012 Feb; 24(1):64-70
PMID: 22196931

Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA
Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.
Clin Cancer Res 2011 Dec 15; 17(24):7704-11
PMID: 22184286

Thompson SL, Compton DA
Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.
Proc Natl Acad Sci U S A 2011 Nov 1; 108(44):17974-8
PMID: 21997207