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Duane A. Compton, Ph.D.

Interim Dean of the Medical School
Professor of Biochemistry
Interim Dean, Geisel School of Medicine at Dartmouth


U. Oklahoma, BS 1984
U. Texas, PHD 1988

Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs


Contact Information:

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755

Professional Interests:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.


Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Mentoring Information:

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.

Selected Publications:


Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Mol Cancer Ther 2015 Aug 24;
PMID: 26304236

Meppelink A, Kabeche L, Vromans MJ, Compton DA, Lens SM
Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.
Cell Rep 2015 Apr 28; 11(4):508-15
PMID: 25892238

Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Cancer Res 2015 May 15; 75(10):2029-38
PMID: 25808870

Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA
Numerical chromosomal instability mediates susceptibility to radiation treatment.
Nat Commun 2015 Jan 21; 6:5990
PMID: 25606712

Godek KM, Kabeche L, Compton DA
Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
Nat Rev Mol Cell Biol 2015 Jan; 16(1):57-64
PMID: 25466864

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA
DNA-damage response during mitosis induces whole-chromosome missegregation.
Cancer Discov 2014 Nov; 4(11):1281-9
PMID: 25107667

Kleyman M, Kabeche L, Compton DA
STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.
J Cell Sci 2014 Oct 1; 127(Pt 19):4225-33
PMID: 25074805

Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D
The mitotic origin of chromosomal instability.
Curr Biol 2014 Feb 17; 24(4):R148-9
PMID: 24556433

Kabeche L, Compton DA
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Nature 2013 Oct 3; 502(7469):110-3
PMID: 24013174

Orr B, Compton DA
A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.
Front Oncol 2013; 3:164
PMID: 23825799