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Duane A. Compton, Ph.D.

Interim Dean of the Medical School
Professor of Biochemistry
Interim Dean, Geisel School of Medicine at Dartmouth


U. Oklahoma, BS 1984
U. Texas, PHD 1988

Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs


Contact Information:

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755

Professional Interests:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.


Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.

Mentoring Information:

Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.

Selected Publications:


Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E
Mol Cancer Ther. 2015 Nov;14(11):2576-85. doi: 10.1158/1535-7163.MCT-15-0443. Epub 2015 Aug 24.
PMID: 26304236

Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.
Meppelink A, Kabeche L, Vromans MJ, Compton DA, Lens SM
Cell Rep. 2015 Apr 28;11(4):508-15. doi: 10.1016/j.celrep.2015.03.052. Epub 2015 Apr 16.
PMID: 25892238

CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E
Cancer Res. 2015 May 15;75(10):2029-38. doi: 10.1158/0008-5472.CAN-14-1494. Epub 2015 Mar 25.
PMID: 25808870

Numerical chromosomal instability mediates susceptibility to radiation treatment.
Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA
Nat Commun. 2015 Jan 21;6:5990. doi: 10.1038/ncomms6990. Epub 2015 Jan 21.
PMID: 25606712

Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
Godek KM, Kabeche L, Compton DA
Nat Rev Mol Cell Biol. 2015 Jan;16(1):57-64. doi: 10.1038/nrm3916. Epub 2014 Dec 3.
PMID: 25466864

DNA-damage response during mitosis induces whole-chromosome missegregation.
Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA
Cancer Discov. 2014 Nov;4(11):1281-9. doi: 10.1158/2159-8290.CD-14-0403. Epub 2014 Aug 8.
PMID: 25107667

STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.
Kleyman M, Kabeche L, Compton DA
J Cell Sci. 2014 Oct 1;127(Pt 19):4225-33. doi: 10.1242/jcs.151613. Epub 2014 Jul 29.
PMID: 25074805

The mitotic origin of chromosomal instability.
Bakhoum SF, Silkworth WT, Nardi IK, Nicholson JM, Compton DA, Cimini D
Curr Biol. 2014 Feb 17;24(4):R148-9. doi: 10.1016/j.cub.2014.01.019.
PMID: 24556433

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Kabeche L, Compton DA
Nature. 2013 Oct 3;502(7469):110-3. doi: 10.1038/nature12507. Epub 2013 Sep 8.
PMID: 24013174

A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.
Orr B, Compton DA
Front Oncol. 2013;3:164. doi: 10.3389/fonc.2013.00164. Epub 2013 Jun 27.
PMID: 23825799