Duane A. Compton, Ph.D.
Interim Dean of the Medical School
Professor of Biochemistry
Interim Dean, Geisel School of Medicine at Dartmouth
U. Oklahoma, BS 1984
U. Texas, PHD 1988
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs
Geisel School of Medicine at Dartmouth
Hanover NH 03755
Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.
Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.
Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.
Numerical chromosomal instability mediates susceptibility to radiation treatment.
Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.
DNA-damage response during mitosis induces whole-chromosome missegregation.
STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.
The mitotic origin of chromosomal instability.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.