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Duane A. Compton, Ph.D.

Title(s):
Professor of Biochemistry

Department(s):
Biochemistry

Education:
U. Oklahoma, BS 1984
U. Texas, PHD 1988

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://geiselmed.dartmouth.edu/compton/

Contact Information:

Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755


Professional Interests:

Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.


Selected Publications:

 

Hood EA, Kettenbach AN, Gerber SA, Compton DA
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.
Mol Biol Cell 2012 Jun; 23(12):2264-74
PMID: 22535524

Bakhoum SF, Compton DA
Chromosomal instability and cancer: a complex relationship with therapeutic potential.
J Clin Invest 2012 Apr 2; 122(4):1138-43
PMID: 22466654

Kabeche L, Compton DA
Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.
Curr Biol 2012 Apr 10; 22(7):638-44
PMID: 22405866

Bakhoum SF, Compton DA
Kinetochores and disease: keeping microtubule dynamics in check!
Curr Opin Cell Biol 2012 Feb; 24(1):64-70
PMID: 22196931

Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA
Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.
Clin Cancer Res 2011 Dec 15; 17(24):7704-11
PMID: 22184286

Thompson SL, Compton DA
Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.
Proc Natl Acad Sci U S A 2011 Nov 1; 108(44):17974-8
PMID: 21997207

Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E
Anaphase catastrophe is a target for cancer therapy.
Clin Cancer Res 2011 Mar 15; 17(6):1218-22
PMID: 21288923

Thompson SL, Compton DA
Chromosomes and cancer cells.
Chromosome Res 2011 Apr; 19(3):433-44
PMID: 21190130

Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.
EMBO J 2010 Oct 20; 29(20):3531-43
PMID: 20852589

Compton DA
Mechanisms of aneuploidy.
Curr Opin Cell Biol 2011 Feb; 23(1):109-13
PMID: 20810265