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David J. Gladstone, Sc.D.

Professor of Medicine
Adjunct Associate Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton Langlois
Asst. Phone: 603-650-6614
Asst. Email: pamela.easton.langlois@hitchcock.org

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. EPR dosimetry.

Grant Information:

NIH/PO1 GM51630-05 Physics Consultant
NIH / NCI 1R43CA78005-01 - Phase II Co-Investigator
ACS grant #IRG82-003016IRG IRG-157M PI
NIH/NCI P01 CA23108-35 Co-director Radiation Shared Resource
NIH/NCI R43 CA103567-01 Co-Investigator

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications.
Glaser AK, Zhang R, Andreozzi JM, Gladstone DJ, Pogue BW
Phys Med Biol. 2015 Sep 7;60(17):6701-18. doi: 10.1088/0031-9155/60/17/6701. Epub 2015 Aug 13.
PMID: 26270125

Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water.
Glaser AK, Andreozzi JM, Zhang R, Pogue BW, Gladstone DJ
Med Phys. 2015 Jul;42(7):4127-36. doi: 10.1118/1.4922135.
PMID: 26133613

Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging.
Andreozzi JM, Zhang R, Glaser AK, Jarvis LA, Pogue BW, Gladstone DJ
Med Phys. 2015 Feb;42(2):994-1004. doi: 10.1118/1.4906249.
PMID: 25652512

Cherenkoscopy based patient positioning validation and movement tracking during post-lumpectomy whole breast radiation therapy.
Zhang R, Andreozzi JM, Gladstone DJ, Hitchcock WL, Glaser AK, Jiang S, Pogue BW, Jarvis LA
Phys Med Biol. 2015 Jan 7;60(1):L1-14. doi: 10.1088/0031-9155/60/1/L1. Epub 2014 Dec 12.
PMID: 25504315

Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies.
Holt RW, Zhang R, Esipova TV, Vinogradov SA, Glaser AK, Gladstone DJ, Pogue BW
Phys Med Biol. 2014 Sep 21;59(18):5317-28. doi: 10.1088/0031-9155/59/18/5317. Epub 2014 Aug 22.
PMID: 25146556

Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose.
Glaser AK, Zhang R, Gladstone DJ, Pogue BW
Phys Med Biol. 2014 Jul 21;59(14):3789-811. doi: 10.1088/0031-9155/59/14/3789. Epub 2014 Jun 18.
PMID: 24938928

Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation.
Glaser AK, Andreozzi JM, Davis SC, Zhang R, Pogue BW, Fox CJ, Gladstone DJ
Med Phys. 2014 Jun;41(6):062102. doi: 10.1118/1.4875704.
PMID: 24877829

Cherenkov video imaging allows for the first visualization of radiation therapy in real time.
Jarvis LA, Zhang R, Gladstone DJ, Jiang S, Hitchcock W, Friedman OD, Glaser AK, Jermyn M, Pogue BW
Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):615-22. doi: 10.1016/j.ijrobp.2014.01.046. Epub 2014 Mar 28.
PMID: 24685442

Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy.
Zhang R, Gladstone DJ, Jarvis LA, Strawbridge RR, Jack Hoopes P, Friedman OD, Glaser AK, Pogue BW
J Biomed Opt. 2013 Nov;18(11):110504. doi: 10.1117/1.JBO.18.11.110504.
PMID: 24247743

Superficial dosimetry imaging based on CŐĆerenkov emission for external beam radiotherapy with megavoltage x-ray beam.
Zhang R, Glaser AK, Gladstone DJ, Fox CJ, Pogue BW
Med Phys. 2013 Oct;40(10):101914. doi: 10.1118/1.4821543.
PMID: 24089916