David J. Gladstone, ScD

Professor of Medicine
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton Langlois
Asst. Phone: 603-650-6614
Asst. Email: pamela.easton.langlois@hitchcock.org

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. EPR dosimetry.

Grant Information:

NIH/PO1 GM51630-05 Physics Consultant
NIH / NCI 1R43CA78005-01 - Phase II Co-Investigator
ACS grant #IRG82-003016IRG IRG-157M PI
NIH/NCI P01 CA23108-35 Co-director Radiation Shared Resource
NIH/NCI R43 CA103567-01 Co-Investigator

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue.
Zhang R, Glaser AK, Andreozzi J, Jiang S, Jarvis LA, Gladstone DJ, Pogue BW
J Biophotonics. 2016 Aug 10; doi: 10.1002/jbio.201500344. Epub 2016 Aug 10.
PMID: 27507213

Dose Specification for NRG Radiation Therapy Trials.
Gladstone DJ, Kry SF, Xiao Y, Chetty IJ
Int J Radiat Oncol Biol Phys. 2016 Aug 1;95(5):1344-5. doi: 10.1016/j.ijrobp.2016.03.044. Epub 2016 Apr 7.
PMID: 27479721

Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation.
Lin H, Zhang R, Gunn JR, Esipova TV, Vinogradov S, Gladstone DJ, Jarvis LA, Pogue BW
Phys Med Biol. 2016 May 21;61(10):3955-68. doi: 10.1088/0031-9155/61/10/3955. Epub 2016 Apr 27.
PMID: 27120085

Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy.
Andreozzi JM, Zhang R, Gladstone DJ, Williams BB, Glaser AK, Pogue BW, Jarvis LA
Med Phys. 2016 Feb;43(2):993-1002. doi: 10.1118/1.4939880.
PMID: 26843259

Quantitative analysis of brass compensators for commissioning of the Pinnacle planning system for IMRT.
Gates LL, Gladstone DJ
J Appl Clin Med Phys. 2015 Nov 8;16(6):5531. Epub 2015 Nov 8.
PMID: 26699564

Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications.
Glaser AK, Zhang R, Andreozzi JM, Gladstone DJ, Pogue BW
Phys Med Biol. 2015 Sep 7;60(17):6701-18. doi: 10.1088/0031-9155/60/17/6701. Epub 2015 Aug 13.
PMID: 26270125

Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water.
Glaser AK, Andreozzi JM, Zhang R, Pogue BW, Gladstone DJ
Med Phys. 2015 Jul;42(7):4127-36. doi: 10.1118/1.4922135.
PMID: 26133613

Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging.
Andreozzi JM, Zhang R, Glaser AK, Jarvis LA, Pogue BW, Gladstone DJ
Med Phys. 2015 Feb;42(2):994-1004. doi: 10.1118/1.4906249.
PMID: 25652512

Cherenkoscopy based patient positioning validation and movement tracking during post-lumpectomy whole breast radiation therapy.
Zhang R, Andreozzi JM, Gladstone DJ, Hitchcock WL, Glaser AK, Jiang S, Pogue BW, Jarvis LA
Phys Med Biol. 2015 Jan 7;60(1):L1-14. doi: 10.1088/0031-9155/60/1/L1. Epub 2014 Dec 12.
PMID: 25504315

Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies.
Holt RW, Zhang R, Esipova TV, Vinogradov SA, Glaser AK, Gladstone DJ, Pogue BW
Phys Med Biol. 2014 Sep 21;59(18):5317-28. doi: 10.1088/0031-9155/59/18/5317. Epub 2014 Aug 22.
PMID: 25146556