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David J. Gladstone, Sc.D.

Title(s):
Professor of Medicine
Adjunct Associate Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center

Department(s):
Medicine

Education:
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Programs:
EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton Langlois
Asst. Phone: 603-650-6614
Asst. Email: pamela.easton.langlois@hitchcock.org


Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. EPR dosimetry.

Grant Information:

NIH/PO1 GM51630-05 Physics Consultant
NIH / NCI 1R43CA78005-01 - Phase II Co-Investigator
ACS grant #IRG82-003016IRG IRG-157M PI
NIH/NCI P01 CA23108-35 Co-director Radiation Shared Resource
NIH/NCI R43 CA103567-01 Co-Investigator

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192


Selected Publications:

 

Glaser AK, Zhang R, Gladstone DJ, Pogue BW
Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose.
Phys Med Biol 2014 Jul 21; 59(14):3789-811
PMID: 24938928

Glaser AK, Andreozzi JM, Davis SC, Zhang R, Pogue BW, Fox CJ, Gladstone DJ
Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation.
Med Phys 2014 Jun; 41(6):062102
PMID: 24877829

Jarvis LA, Zhang R, Gladstone DJ, Jiang S, Hitchcock W, Friedman OD, Glaser AK, Jermyn M, Pogue BW
Cherenkov video imaging allows for the first visualization of radiation therapy in real time.
Int J Radiat Oncol Biol Phys 2014 Jul 1; 89(3):615-22
PMID: 24685442

Zhang R, Gladstone DJ, Jarvis LA, Strawbridge RR, Jack Hoopes P, Friedman OD, Glaser AK, Pogue BW
Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy.
J Biomed Opt 2013 Nov; 18(11):110504
PMID: 24247743

Zhang R, Glaser AK, Gladstone DJ, Fox CJ, Pogue BW
Superficial dosimetry imaging based on Čerenkov emission for external beam radiotherapy with megavoltage x-ray beam.
Med Phys 2013 Oct; 40(10):101914
PMID: 24089916

Zhang R, Fox CJ, Glaser AK, Gladstone DJ, Pogue BW
Superficial dosimetry imaging of Čerenkov emission in electron beam radiotherapy of phantoms.
Phys Med Biol 2013 Aug 21; 58(16):5477-93
PMID: 23880473

Zhang R, Davis SC, Demers JL, Glaser AK, Gladstone DJ, Esipova TV, Vinogradov SA, Pogue BW
Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation.
J Biomed Opt 2013 May; 18(5):50503
PMID: 23644902

Demers JL, Davis SC, Zhang R, Gladstone DJ, Pogue BW
Čerenkov excited fluorescence tomography using external beam radiation.
Opt Lett 2013 Apr 15; 38(8):1364-6
PMID: 23595486

Glaser AK, Voigt WH, Davis SC, Zhang R, Gladstone DJ, Pogue BW
Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams.
Opt Lett 2013 Mar 1; 38(5):634-6
PMID: 23455248

Glaser AK, Davis SC, Voigt WH, Zhang R, Pogue BW, Gladstone DJ
Projection imaging of photon beams using Čerenkov-excited fluorescence.
Phys Med Biol 2013 Feb 7; 58(3):601-19
PMID: 23318469