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Margaret Rita Karagas, Ph.D.

Title(s):
Department Chair
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Crystal Flaherty
Asst. Phone: 603-653-9022
Asst. Email: Crystal.M.Flaherty@Dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K
High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy.
Anal Bioanal Chem 2015 Jul 3;
PMID: 26138895

Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR
Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study.
Toxicol Appl Pharmacol 2015 Jun 3;
PMID: 26048586

Davis MA, Higgins J, Li Z, Gilbert-Diamond D, Baker ER, Das A, Karagas MR
Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports.
Environ Health 2015 Mar 30; 14:12
PMID: 25971349

Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ
Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero.
Epigenetics 2015; 10(6):508-15
PMID: 25923418

Liang C, Kelsey KT, McClean MD, Christensen BC, Marsit CJ, Karagas MR, Waterboer T, Pawlita M, Nelson HH
A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.
PLoS One 2015; 10(4):e0123716
PMID: 25853559

Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC
Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis.
J Pediatr 2015 Jul; 167(1):138-147.e3
PMID: 25818499

Punshon T, Davis MA, Marsit CJ, Theiler SK, Baker ER, Jackson BP, Conway DC, Karagas MR
Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort.
J Expo Sci Environ Epidemiol 2015 Mar 25;
PMID: 25805251

Romano ME, Webster GM, Vuong AM, Thomas Zoeller R, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM
Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study.
Environ Res 2015 Apr; 138:453-60
PMID: 25794847

Farzan SF, Chen Y, Wu F, Jiang J, Liu M, Baker E, Korrick SA, Karagas MR
Blood Pressure Changes in Relation to Arsenic Exposure in a U.S. Pregnancy Cohort.
Environ Health Perspect 2015 Mar 20;
PMID: 25793356

Beane Freeman LE, Karagas MR, Baris D, Schwenn M, Johnson AT, Colt JS, Jackson B, Hosain GM, Cantor KP, Silverman DT
Is the inverse association between selenium and bladder cancer due to confounding by smoking?
Am J Epidemiol 2015 Apr 1; 181(7):488-95
PMID: 25776013