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Margaret Rita Karagas, Ph.D.

Department Chair
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Community and Family Medicine

University of Washington, PhD 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences


Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Crystal Flaherty
Asst. Phone: 603-653-9022
Asst. Email: Crystal.M.Flaherty@Dartmouth.edu

Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.

Selected Publications:


Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.
Figueroa JD, Koutros S, Colt JS, Kogevinas M, Garcia-Closas M, Real FX, Friesen MC, Baris D, Stewart P, Schwenn M, Johnson A, Karagas MR, Armenti KR, Moore LE, Schned A, Lenz P, Prokunina-Olsson L, Banday AR, Paquin A, Ylaya K, Chung JY, Hewitt SM, Nickerson ML, Tardon A, Serra C, Carrato A, Garcia-Closas R, Lloreta J, Malats N, Fraumeni JF Jr, Chanock SJ, Chatterjee N, Rothman N, Silverman DT
J Natl Cancer Inst. 2015 Nov;107(11) pii: djv223. doi: 10.1093/jnci/djv223. Epub 2015 Sep 14.
PMID: 26374428

Infant Infections and Respiratory Symptoms in Relation to <i>in Utero</i> Arsenic Exposure in a U.S. Cohort.
Farzan SF, Li Z, Korrick SA, Spiegelman D, Enelow R, Nadeau K, Baker E, Karagas MR
Environ Health Perspect. 2015 Sep 11; Epub 2015 Sep 11.
PMID: 26359651

Eruptive Squamous Cell Carcinomas of the Keratoacanthoma Type Arising in a Cosmetic Lip Tattoo.
Barton DT, Karagas MR, Samie FH
Dermatol Surg. 2015 Oct;41(10):1190-3. doi: 10.1097/DSS.0000000000000459.
PMID: 26336055

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.
Winterbottom EF, Fei DL, Koestler DC, Giambelli C, Wika E, Capobianco AJ, Lee E, Marsit CJ, Karagas MR, Robbins DJ
EBioMedicine. 2015 Jun;2(6):536-43. doi: 10.1016/j.ebiom.2015.04.019. Epub 2015 May 1.
PMID: 26288817

Arsenic and Rice: Translating Research to Address Health Care Providers' Needs.
Lai PY, Cottingham KL, Steinmaus C, Karagas MR, Miller MD
J Pediatr. 2015 Oct;167(4):797-803. doi: 10.1016/j.jpeds.2015.07.003. Epub 2015 Aug 4.
PMID: 26253210

Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.
Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ
Endocrinology. 2015 Oct;156(10):3408-15. doi: 10.1210/EN.2015-1350. Epub 2015 Aug 4.
PMID: 26241067

Drinking Water Arsenic Contamination, Skin Lesions, and Malignancies: A Systematic Review of the Global Evidence.
Karagas MR, Gossai A, Pierce B, Ahsan H
Curr Environ Health Rep. 2015 Mar;2(1):52-68. doi: 10.1007/s40572-014-0040-x.
PMID: 26231242

Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.
Farzan SF, Karagas MR, Jiang J, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Bryan MS, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Graziano J, Ahsan H, Chen Y
Toxicol Appl Pharmacol. 2015 Oct 1;288(1):95-105. doi: 10.1016/j.taap.2015.07.017. Epub 2015 Jul 26.
PMID: 26220686

Re: "Is the Inverse Association Between Selenium and Bladder Cancer Due to Confounding by Smoking?".
Beane Freeman LE, Karagas MR, Baris D
Am J Epidemiol. 2015 Aug 1;182(3):280. doi: 10.1093/aje/kwv185.
PMID: 26220484

Alcohol consumption and risk of melanoma among women: pooled analysis of eight case-control studies.
Miura K, Zens MS, Peart T, Holly EA, Berwick M, Gallagher RP, Mack TM, Elwood JM, Karagas MR, Green AC
Arch Dermatol Res. 2015 Jul 16; Epub 2015 Jul 16.
PMID: 26179744