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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort.
Farzan SF, Brickley EB, Li Z, Gilbert-Diamond D, Gossai A, Chen Y, Howe CG, Palys T, Karagas MR
Environ Res. 2017 Apr 11;156:426-433. doi: 10.1016/j.envres.2017.03.056. Epub 2017 Apr 11.
PMID: 28410520

Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period.
Martin E, Smeester L, Bommarito PA, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC
Epigenomics. 2017 Mar;9(3):267-278. doi: 10.2217/epi-2016-0132. Epub 2017 Feb 17.
PMID: 28234023

Assessment of human dietary exposure to arsenic through rice.
Davis MA, Signes-Pastor AJ, Argos M, Slaughter F, Pendergrast C, Punshon T, Gossai A, Ahsan H, Karagas MR
Sci Total Environ. 2017 May 15;586:1237-1244. doi: 10.1016/j.scitotenv.2017.02.119. Epub 2017 Feb 21.
PMID: 28233618

Charting the Maternal and Infant Microbiome: What Is the Role of Diabetes and Obesity in Pregnancy?
Singh S, Karagas MR, Mueller NT
Curr Diab Rep. 2017 Feb;17(2):11. doi: 10.1007/s11892-017-0836-9.
PMID: 28176229

The Unintended Consequences of a Gluten-free Diet.
Bulka CM, Davis MA, Karagas MR, Ahsan H, Argos M
Epidemiology. 2017 May;28(3):e24-e25. doi: 10.1097/EDE.0000000000000640.
PMID: 28166100

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data.
Shi J, Park JH, Duan J, Berndt ST, Moy W, Yu K, Song L, Wheeler W, Hua X, Silverman D, Garcia-Closas M, Hsiung CA, Figueroa JD, Cortessis VK, Malats N, Karagas MR, Vineis P, Chang IS, Lin D, Zhou B, Seow A, Matsuo K, Hong YC, Caporaso NE, Wolpin B, Jacobs E, Petersen GM, Klein AP, Li D, Risch H, Sanders AR, Hsu L, Schoen RE, Brenner H, MGS (Molecular Genetics of Schizophrenia) GWAS Consortium., GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium)., GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium., PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium., PanScan Consortium., GAME-ON/ELLIPSE Consortium., Stolzenberg-Solomon R, Gejman P, Lan Q, Rothman N, Amundadottir LT, Landi MT, Levinson DF, Chanock SJ, Chatterjee N
PLoS Genet. 2016 Dec;12(12):e1006493. doi: 10.1371/journal.pgen.1006493. Epub 2016 Dec 30.
PMID: 28036406

Human exposure to organic arsenic species from seafood.
Taylor V, Goodale B, Raab A, Schwerdtle T, Reimer K, Conklin S, Karagas MR, Francesconi KA
Sci Total Environ. 2017 Feb 15;580:266-282. doi: 10.1016/j.scitotenv.2016.12.113. Epub 2016 Dec 24.
PMID: 28024743

DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.
Koestler DC, Usset J, Christensen BC, Marsit CJ, Karagas MR, Kelsey KT, Wiencke JK
Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):328-338. doi: 10.1158/1055-9965.EPI-16-0461. Epub 2016 Dec 13.
PMID: 27965295

Skin microtopography as a measure of photoaging and risk of squamous cell carcinoma of the skin in a US population.
Kuklinski LF, Zens MS, Perry AE, Green AC, Karagas MR
Photodermatol Photoimmunol Photomed. 2017 Jan;33(1):41-48. doi: 10.1111/phpp.12280. Epub 2017 Jan 17.
PMID: 27864996

Maternal arsenic exposure and gestational diabetes and glucose intolerance in the New Hampshire birth cohort study.
Farzan SF, Gossai A, Chen Y, Chasan-Taber L, Baker E, Karagas M
Environ Health. 2016 Nov 8;15(1):106. Epub 2016 Nov 8.
PMID: 27825389