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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case-Control Study (New England, USA).
Beane Freeman LE, Cantor KP, Baris D, Nuckols JR, Johnson A, Colt JS, Schwenn M, Ward MH, Lubin JH, Waddell R, Hosain GM, Paulu C, McCoy R, Moore LE, Huang AT, Rothman N, Karagas MR, Silverman DT
Environ Health Perspect. 2017 Jun 21;125(6):067010. doi: 10.1289/EHP89. Epub 2017 Jun 21.
PMID: 28636529

Distinct arsenic metabolites following seaweed consumption in humans.
Taylor VF, Li Z, Sayarath V, Palys TJ, Morse KR, Scholz-Bright RA, Karagas MR
Sci Rep. 2017 Jun 20;7(1):3920. doi: 10.1038/s41598-017-03883-7. Epub 2017 Jun 20.
PMID: 28634348

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.
Winterbottom EF, Koestler DC, Fei DL, Wika E, Capobianco AJ, Marsit CJ, Karagas MR, Robbins DJ
Environ Health. 2017 Jun 14;16(1):59. doi: 10.1186/s12940-017-0267-8. Epub 2017 Jun 14.
PMID: 28615018

Wood Stove Pollution in the Developed World: A Case to Raise Awareness Among Pediatricians.
Rokoff LB, Koutrakis P, Garshick E, Karagas MR, Oken E, Gold DR, Fleisch AF
Curr Probl Pediatr Adolesc Health Care. 2017 Jun 2; pii: S1538-5442(17)30081-0. doi: 10.1016/j.cppeds.2017.04.001. Epub 2017 Jun 2.
PMID: 28583817

Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life.
Kaushal A, Zhang H, Karmaus WJJ, Everson TM, Marsit CJ, Karagas MR, Tsai SF, Wen HJ, Wang SL
Environ Health. 2017 May 30;16(1):50. doi: 10.1186/s12940-017-0262-0. Epub 2017 May 30.
PMID: 28558807

Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation.
Appleton AA, Jackson BP, Karagas M, Marsit CJ
Epigenetics. 2017 May 26;:0. doi: 10.1080/15592294.2017.1320637. Epub 2017 May 26.
PMID: 28548590

Levels of infants' urinary arsenic metabolites related to formula feeding and weaning with rice products exceeding the EU inorganic arsenic standard.
Signes-Pastor AJ, Woodside JV, McMullan P, Mullan K, Carey M, Karagas MR, Meharg AA
PLoS One. 2017;12(5):e0176923. doi: 10.1371/journal.pone.0176923. Epub 2017 May 4.
PMID: 28472079

Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort.
Farzan SF, Brickley EB, Li Z, Gilbert-Diamond D, Gossai A, Chen Y, Howe CG, Palys T, Karagas MR
Environ Res. 2017 Jul;156:426-433. doi: 10.1016/j.envres.2017.03.056. Epub 2017 Apr 12.
PMID: 28410520

Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period.
Martin E, Smeester L, Bommarito PA, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC
Epigenomics. 2017 Mar;9(3):267-278. doi: 10.2217/epi-2016-0132. Epub 2017 Feb 17.
PMID: 28234023

Assessment of human dietary exposure to arsenic through rice.
Davis MA, Signes-Pastor AJ, Argos M, Slaughter F, Pendergrast C, Punshon T, Gossai A, Ahsan H, Karagas MR
Sci Total Environ. 2017 May 15;586:1237-1244. doi: 10.1016/j.scitotenv.2017.02.119. Epub 2017 Feb 21.
PMID: 28233618