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Margaret Rita Karagas, Ph.D.

Title(s):
Department Chair
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Crystal Flaherty
Asst. Phone: 603-653-9022
Asst. Email: Crystal.M.Flaherty@Dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Winterbottom EF, Fei DL, Koestler DC, Giambelli C, Wika E, Capobianco AJ, Lee E, Marsit CJ, Karagas MR, Robbins DJ
GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.
EBioMedicine 2015 Jun; 2(6):536-43
PMID: 26288817

Lai PY, Cottingham KL, Steinmaus C, Karagas MR, Miller MD
Arsenic and Rice: Translating Research to Address Health Care Providers' Needs.
J Pediatr 2015 Aug 4;
PMID: 26253210

Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ
Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.
Endocrinology 2015 Aug 4; :EN20151350
PMID: 26241067

Karagas MR, Gossai A, Pierce B, Ahsan H
Drinking Water Arsenic Contamination, Skin Lesions, and Malignancies: A Systematic Review of the Global Evidence.
Curr Environ Health Rep 2015 Mar; 2(1):52-68
PMID: 26231242

Farzan SF, Karagas MR, Jiang J, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Bryan MS, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Graziano J, Ahsan H, Chen Y
Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.
Toxicol Appl Pharmacol 2015 Jul 26; 288(1):95-105
PMID: 26220686

Miura K, Zens MS, Peart T, Holly EA, Berwick M, Gallagher RP, Mack TM, Elwood JM, Karagas MR, Green AC
Alcohol consumption and risk of melanoma among women: pooled analysis of eight case-control studies.
Arch Dermatol Res 2015 Jul 16;
PMID: 26179744

Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K
High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy.
Anal Bioanal Chem 2015 Sep; 407(22):6839-50
PMID: 26138895

Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR
Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study.
Toxicol Appl Pharmacol 2015 Sep 1; 287(2):93-7
PMID: 26048586

Davis MA, Higgins J, Li Z, Gilbert-Diamond D, Baker ER, Das A, Karagas MR
Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports.
Environ Health 2015 Mar 30; 14:12
PMID: 25971349

Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ
Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero.
Epigenetics 2015; 10(6):508-15
PMID: 25923418