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Christopher I Amos, PHD

Title(s):
Department Chair
Chair and Professor of Biomedical Data Science
Professor of Community and Family Medicine
Professor of Genetics
Associate Director for Population Sciences, Norris Cotton Cancer Center

Department(s):
Biomedical Data Science
Community and Family Medicine
Genetics

Education:
M.S. Biometry, LSU Medical Center in New Orleans, 1985
Ph.D. LSU Medical Center in New Orleans, 1988
FACMG - NIH Interinstitute Training Program in Genetics, 1992

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences
SYNERGY

Contact Information:

Williamson Translational Building - 3
1 Medical Center Drive
Lebanon NH 03756

Office: WTRB
Phone: 603-650-1972
Email: Christopher.I.Amos@Dartmouth.edu

Assistant: Lamar D. MOss
Asst. Phone: (603) 650-1763
Asst. Email: Lamar.D.Moss@Dartmouth.edu


Professional Interests:

Genetic Epidemiology, Statistical Genetics, Cancer Genetics, Autoimmune Diseases, Lung Cancer Etiology, Genomics of Colon Cancer, Personalized Medicine, Next Generation Sequencing, Statistical aspects of design of studies

Rotations and Thesis Projects:

Analysis of the Oncoarray, a project involving study of 500,000 individuals half of whom have one of the common cancers (lung, breast, colon, ovary or prostate cancer). Genomic analysis of susceptibility to rare and common cancers and melanoma.

Grant Information:

Transdisciplinary Research in Cancer of the Lung (TRICL), U19 CA148127
Topography and Genetics of Smoking and Nicotine Dependence in American Indians, 1 P50 Ca148110 02
Norris Cotton Cancer Center Support Grant 5 P30CA0123108-28
The UT MD Anderson Cancer Center SPORE in Melanoma, P50CA093459

Courses Taught:

Statistical Genetics
Genetics Then and Now
Seminars in Biostatistics
Categorical Data Analysis

Biography:

My focus has been in the development and application of novel methods for understanding the basis of inherited predisposition to cancer and other complex diseases. I developed design criteria for the conduct of genetics studies and subsequently applied these for studying families and for population based analysis. I colead the international Genetic Associations and Mechanisms in Oncology (GAME-ON) consortium which brings together population-based researchers studying genetic and environmental causes of lung, breast, prostate, colon and ovarian cancers.


Selected Publications:

 

  • Wang Y., McKay JD...Amos CI. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 2014 Jul;46(7):736-41. (view details on MedLine)

  • Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet. 2011 Mar;79(3):199-206 (view details on MedLine)

  • Tsongalis GJ, Peterson JD, de Abreu FB, Tunkey CD, Gallagher TL, Strausbaugh LD, Wells WA, Amos CI. Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations.sequencing to identify somatic mutations. Clin Chem Lab Med. 2014 May;52(5):707-14 (view details on MedLine)

  • Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60 (view details on MedLine)

  • Amos CI Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet. 1994 Mar;54(3):535-43. (view details on MedLine)

  • Li Y, Huang J, Amos CI. Genetic association analysis of complex diseases incorporating intermediate phenotype information. PLoS One. 2012;7(10):e46612. (view details on MedLine)

  • Ma J, Xiong M, You M, Lozano G, Amos CI. Genome-wide association tests of inversions with application to psoriasis. Hum Genet. 2014 Aug;133(8):967-74. (view details on MedLine)

  • Kar SP, Seldin MF, Chen W, Lu E, Hirschfield GM, Invernizzi P, Heathcote J, Cusi D; Italian PBC Genetics Study Group, Gershwin ME, Siminovitch KA, Amos CI. Pathway-based analysis of primary biliary cirrhosis genome-wide association studies. Genes Immun. 2013 Apr;14(3):179-86. (view details on MedLine)

  • Qian DC, Byun J, Han Y, Greene CS, Field JK, Hung RJ, Brhane Y, Mclaughlin JR, Fehringer G, Landi MT, Rosenberger A, Bickeböller H, Malhotra J, Risch A, Heinrich J, Hunter DJ, Henderson BE, Haiman CA, Schumacher FR, Eeles RA, Easton DF, Seminara D, Amos C Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions. Hum Mol Genet. 2015 Dec 20;24(25):7406-20. (view details on MedLine)

  • Xiao F, Ma J, Cai G, Fang S, Lee JE, Wei Q, Amos CI. Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.. Hum Genet. 2014 May;133(5):559-74 (view details on MedLine)