David W Mullins, PhD
Assistant Professor of Microbiology and Immunology
Assistant Professor of Medical Education
Microbiology and Immunology
BS, Biology (Microbiology), Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
BS, Biochemistry,Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Ph.D., Microbiology and Immunology, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Postdoctoral, Cancer Immunology and Immunotherapy, Carter Immunology Center, University of Virginia, Charlottesville, VA
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
HB7100, Remsen 229
Hanover NH 03755
Office: Remsen 229
Cancer Immunology and Immunotherapy, including 1) Lymphocyte Trafficking and Infiltration of Tumors, 2) Biological Therapies for Cancer, and 3) Innate Immunity in Anti-cancer Therapy.
Undergraduate Medical Education.
Rotations and Thesis Projects:
- Matthew P. Alexander, Ph.D. Candidate, Modulation of the melanoma microenvironment to enhance T cell infiltration.
- Amanda Costa, Ph.D. Student.
- Kiah Sanders, Ph.D. (Dr. David Bzik, Co-Mentor)
Geisel Medical Students:
- Meagan Dechen, M.S., Geisel year 2
Dartmouth Undergraduate Students:
- Kristen Vondrak '16
- Molly Harris-Jenkins, Ph.D. (PostDoc, 2012-2015). Research Scientist, Minerva Biotechnologies, Waltham, MA.
- Eleanor Clancy-Thompson, PhD. (PhD, December 2014). Postdoctoral fellow, Dana Farber Cancer Institute, Boston, MA
- Tom Perekslis (technician, 2012-14). Jackson Labs, Bar Harbor, ME
Undergrad Research Students:
- Sasha Alcon (Junior/Senior Science Scholar, 2013-15).
- Julia Bratic (Presidential Science Scholar, 2013-15).
- Julianne Ivy (Presidential Science Scholar, 2013-15).
Melanoma Research Alliance, Young Investigator Award, 2008
USPHS R01 CA134799, Role of CD8 T cell CXCR3 in the Regulation of Cancer, 2009-2014
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Eleanor Clancy-Thompson, 2012-13
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Matthew P. Alexander, 2013-14
Harry J. Lloyd Charitable Trust, Research Grant 2014-15
USPHS R03 CA188418, Combinatorial therapy of melanoma using T cells and site-specific Immunomodulators, 2015-2017.
- Medical Immunology and Virology (MICR111), Immunology Course Director
- Cellular and Molecular Basis of Immunity (MICR144), Tumor Immunology and Transplantation
- Cancer Immunology and Immunotherapy (Geisel Elective), Course Director
The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells.
Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles.
Site-Specific Immunomodulator: A Novel Treatment for Crohn's Disease.
Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.
The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells.
CXCR3 signaling in BRAFWT melanoma increases IL-8 expression and tumorigenicity.
BRAF inhibition alleviates immune suppression in murine autochthonous melanoma.
Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Peptide vaccination in Montanide adjuvant induces and GM-CSF increases CXCR3 and cutaneous lymphocyte antigen expression by tumor antigen-specific CD8 T cells.
Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas.