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David W Mullins, Ph.D.

Title(s):
Assistant Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
BS, Biology (Microbiology), Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
BS, Biochemistry,Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Ph.D., Microbiology and Immunology, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Postdoctoral, Cancer Immunology and Immunotherapy, Carter Immunology Center, University of Virginia, Charlottesville, VA

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Contact Information:

HB7937, Rubin 733
Rubin 733, HB7937
Lebanon NH 03756

Office: Rubin 733
Phone: 603-653-9922
Email: David.W.Mullins@Dartmouth.edu

Asst. Email: david.w.mullins@dartmouth.edu


Professional Interests:

Cancer Immunology and Immunotherapy; Lymphocyte Trafficking and Infiltration of Tumors; Melanoma Cell Biology

Rotations and Thesis Projects:

Current Students:
- Eleanor Clancy-Thompson, PhD Candidate, Melanoma-induced expression of chemokines in the tumor microenvironment.
- Matthew P. Alexander, Ph.D. Candidate, Modulation of the melanoma microenvironment to enhance T cell infiltration.

Post-Docs:
- Molly Harris-Jenkins, Ph.D., Regulation of CXCR3 and Metastasis Genes in Melanoma (Constance Brinckerhoff, Co-Mentor)

Undergrad Research Students:
- Sasha Alcon, Junior Science Scholar
- Julia Bratic, Presidential Science Scholar
- Julianne Ivy, Presidential Science Scholar

Grant Information:

Melanoma Research Alliance, Young Investigator Award, 2008
USPHS R01 CA134799, Role of CD8 T cell CXCR3 in the Regulation of Cancer, 2009-2014
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Eleanor Clancy-Thompson, 2012-13
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Matthew P. Alexander, 2013-14


Selected Publications:

 

Steinberg SM, Zhang P, Malik BT, Boni A, Shabaneh TB, Byrne KT, Mullins DW, Brinckerhoff CE, Ernstoff MS, Bosenberg MW, Turk MJ
BRAF Inhibition Alleviates Immune Suppression in Murine Autochthonous Melanoma.
Cancer Immunol Res 2014 Nov; 2(11):1044-50
PMID: 25183499

Jenkins MH, Steinberg SM, Alexander MP, Fisher JL, Ernstoff MS, Turk MJ, Mullins DW, Brinckerhoff CE
Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Pigment Cell Melanoma Res 2014 May; 27(3):495-501
PMID: 24460976

Clancy-Thompson E, King LK, Nunnley LD, Mullins IM, Slingluff CL Jr, Mullins DW
Peptide vaccination in Montanide adjuvant induces and GM-CSF increases CXCR3 and cutaneous lymphocyte antigen expression by tumor antigen-specific CD8 T cells.
Cancer Immunol Res 2013 Nov; 1(5):332-9
PMID: 24377099

Oliver JL, Alexander MP, Norrod AG, Mullins IM, Mullins DW
Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas.
Pigment Cell Melanoma Res 2013 Jul; 26(4):571-9
PMID: 23490134

Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.
J Immunol 2013 Jan 1; 190(1):469-78
PMID: 23225891

Croteau W, Jenkins MH, Ye S, Mullins DW, Brinckerhoff CE
Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma.
J Cell Physiol 2013 Apr; 228(4):773-80
PMID: 23001823

Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.
J Biol Chem 2011 Mar 25; 286(12):10847-55
PMID: 21282107

Iype T, Sankarshanan M, Mauldin IS, Mullins DW, Lorenz U
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
J Immunol 2010 Nov 15; 185(10):6115-27
PMID: 20952680

Dengel LT, Norrod AG, Gregory BL, Clancy-Thompson E, Burdick MD, Strieter RM, Slingluff CL Jr, Mullins DW
Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma.
J Immunother 2010 Nov-Dec; 33(9):965-74
PMID: 20948440

Slingluff CL Jr, Chianese-Bullock KA, Bullock TN, Grosh WW, Mullins DW, Nichols L, Olson W, Petroni G, Smolkin M, Engelhard VH
Immunity to melanoma antigens: from self-tolerance to immunotherapy.
Adv Immunol 2006; 90:243-95
PMID: 16730266