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David W Mullins, Ph.D.

Title(s):
Assistant Professor of Micro Immunology
Adjunct Faculty, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA

Department(s):
Micro Immunology

Education:
BS, Biology (Microbiology), Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
BS, Biochemistry,Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Ph.D., Microbiology and Immunology, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Postdoctoral, Cancer Immunology and Immunotherapy, Carter Immunology Center, University of Virginia, Charlottesville, VA

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Contact Information:

HB7937, Rubin 733
Rubin 733, HB7937
Lebanon NH 03756

Office: Rubin 733
Phone: 603-653-9922
Email: David.W.Mullins@Dartmouth.edu

Asst. Email: david.w.mullins@dartmouth.edu

Professional Interests:

Cancer Immunology and Immunotherapy; Lymphocyte Trafficking and Infiltration of Tumors; Melanoma Cell Biology

Rotations and Thesis Projects:

Current Students:
1. Eleanor Clancy-Thompson, PhD Candidate, Melanoma-induced expression of chemokines in the tumor microenvironment.
2. Matthew P. Alexander, Ph.D. Candidate, Modulation of the melanoma microenvironment to enhance T cell infiltration.
3. Debbie Travers, MCB Rotation Student

Post-Docs:
1. Molly Harris-Jenkins, Ph.D., Regulation of CXCR3 and Metastasis Genes in Melanoma (Constance Brinckerhoff, Co-Mentor)

Undergrad Research Students:
1. Julia Bratic, Sophomore Science Scholar
2. Sasha Alcon, Sophomore Science Scholar

Grant Information:

Melanoma Research Alliance, Young Investigator Award, 2008
USPHS R01 CA134799, Role of CD8 T cell CXCR3 in the Regulation of Cancer, 2009-2014
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Eleanor Clancy-Thompson, 2012-13

Selected Publications:
 

Oliver JL, Alexander MP, Norrod AG, Mullins IM, Mullins DW
Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas.
Pigment Cell Melanoma Res 2013 Mar 11;
PMID: 23490134

Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.
J Immunol 2013 Jan 1; 190(1):469-78
PMID: 23225891

Croteau W, Jenkins MH, Ye S, Mullins DW, Brinckerhoff CE
Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma.
J Cell Physiol 2013 Apr; 228(4):773-80
PMID: 23001823

Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.
J Biol Chem 2011 Mar 25; 286(12):10847-55
PMID: 21282107

Iype T, Sankarshanan M, Mauldin IS, Mullins DW, Lorenz U
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
J Immunol 2010 Nov 15; 185(10):6115-27
PMID: 20952680

Dengel LT, Norrod AG, Gregory BL, Clancy-Thompson E, Burdick MD, Strieter RM, Slingluff CL Jr, Mullins DW
Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma.
J Immunother 2010 Nov-Dec; 33(9):965-74
PMID: 20948440

Slingluff CL Jr, Chianese-Bullock KA, Bullock TN, Grosh WW, Mullins DW, Nichols L, Olson W, Petroni G, Smolkin M, Engelhard VH
Immunity to melanoma antigens: from self-tolerance to immunotherapy.
Adv Immunol 2006; 90:243-95
PMID: 16730266

Chang CC, Ogino T, Mullins DW, Oliver JL, Yamshchikov GV, Bandoh N, Slingluff CL Jr, Ferrone S
Defective human leukocyte antigen class I-associated antigen presentation caused by a novel beta2-microglobulin loss-of-function in melanoma cells.
J Biol Chem 2006 Jul 7; 281(27):18763-73
PMID: 16648140

Mullins DW, Engelhard VH
Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes.
J Immunol 2006 Apr 15; 176(8):4535-42
PMID: 16585543

Yamshchikov GV, Mullins DW, Chang CC, Ogino T, Thompson L, Presley J, Galavotti H, Aquila W, Deacon D, Ross W, Patterson JW, Engelhard VH, Ferrone S, Slingluff CL Jr
Sequential immune escape and shifting of T cell responses in a long-term survivor of melanoma.
J Immunol 2005 Jun 1; 174(11):6863-71
PMID: 15905528