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David W Mullins, PhD

Title(s):
Assistant Professor of Office of Medical Education
Assistant Professor of Microbiology and Immunology
Assistant Professor of Medical Education

Department(s):
Office of Medical Education
Microbiology and Immunology

Education:
BS, Biology (Microbiology), Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
BS, Biochemistry,Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Ph.D., Microbiology and Immunology, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Postdoctoral, Cancer Immunology and Immunotherapy, Carter Immunology Center, University of Virginia, Charlottesville, VA

Programs:
Academy of Master Faculty Educators
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
https://www.linkedin.com/in/david-mullins-1981785a

Contact Information:

Remsen 232
HB7100
Hanover NH 03755

Office: Remsen 232
Phone: 603-650-1208
Email: David.W.Mullins@Dartmouth.edu


Professional Interests:

Cancer Immunology and Immunotherapy, including 1) Lymphocyte Trafficking and Infiltration of Tumors, 2) Biological Therapies for Cancer, and 3) Innate Immunity in Anti-cancer Therapy.

Undergraduate Medical Education.

Rotations and Thesis Projects:

Current Students:
- Matthew P. Alexander, Ph.D. Candidate
- Amanda Costa, Ph.D. Student.

Geisel Medical Students:
- Meagan Dechen, M.S., Geisel year 2

Lab Alumni::
- Kiah Sanders, Ph.D. (PostDoc 2015-2016). Research Scientist, Merck Research Laboratories, Palo Alto, CA
- Kristen Vondrak '16 (Undergraduate Research Scholar, 2015-2016).
- Molly Harris-Jenkins, Ph.D. (PostDoc, 2012-2015). Research Scientist, Minerva Biotechnologies, Waltham, MA
- Eleanor Clancy-Thompson, PhD. (PhD, December 2014). Postdoctoral fellow, Dana Farber Cancer Institute, Boston, MA
- Tom Perekslis (technician, 2012-14). Jackson Labs, Bar Harbor, ME
Undergrad Research Students:
- Sasha Alcon '15 (Junior/Senior Science Scholar, 2013-15).
- Julia Bratic '15 (Presidential Science Scholar, 2013-15). MD/MPH student, UT Southwestern, Dallas, TX
- Julianne Ivy '15 (Presidential Science Scholar, 2013-15).

Grant Information:

Melanoma Research Alliance, Young Investigator Award, 2008
USPHS R01 CA134799, Role of CD8 T cell CXCR3 in the Regulation of Cancer, 2009-2014
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Eleanor Clancy-Thompson, 2012-13
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Matthew P. Alexander, 2013-14
Harry J. Lloyd Charitable Trust, Research Grant 2014-15
USPHS R03 CA188418, Combinatorial therapy of melanoma using T cells and site-specific Immunomodulators, 2015-2017.

Courses Taught:

Course Director:
- Medical Immunology and Virology (MICR111)
- Basic Science of Microbial Disease (MICR112)
- Cancer Immunology and Immunotherapy (Geisel Enrichment Elective)

Participating Faculty:
- Cellular and Molecular Basis of Immunity (MICR144), Tumor Immunology and Transplantation
- Biochemistry and Genetic Basis of Medicine (BIOC110)


Selected Publications:

 

Adaptive immunity programmes in breast cancer.
Varn FS, Mullins DW, Arias-Pulido H, Fiering S, Cheng C
Immunology. 2016 Aug 26; doi: 10.1111/imm.12664. Epub 2016 Aug 26.
PMID: 27564847

Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases.
Mauldin IS, Wages NA, Stowman AM, Wang E, Olson WC, Deacon DH, Smith KT, Galeassi N, Teague JE, Smolkin ME, Chianese-Bullock KA, Clark RA, Petroni GR, Marincola FM, Mullins DW, Slingluff CL Jr
Cancer Immunol Immunother. 2016 Oct;65(10):1201-12. doi: 10.1007/s00262-016-1880-z. Epub 2016 Aug 13.
PMID: 27522582

Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases.
Mauldin IS, Wages NA, Stowman AM, Wang E, Smolkin ME, Olson WC, Deacon DH, Smith KT, Galeassi NV, Chianese-Bullock KA, Dengel LT, Marincola FM, Petroni GR, Mullins DW, Slingluff CL Jr
Cancer Immunol Immunother. 2016 Oct;65(10):1189-99. doi: 10.1007/s00262-016-1881-y. Epub 2016 Aug 13.
PMID: 27522581

The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells.
Whipple CA, Boni A, Fisher JL, Hampton TH, Tsongalis GJ, Mellinger DL, Yan S, Tafe LJ, Brinckerhoff CE, Turk MJ, Mullins DW, Fadul CE, Ernstoff MS
Melanoma Res. 2016 Jun;26(3):223-35. doi: 10.1097/CMR.0000000000000244.
PMID: 26974965

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles.
Varn FS, Andrews EH, Mullins DW, Cheng C
Nat Commun. 2016 Jan 4;7:10248. doi: 10.1038/ncomms10248. Epub 2016 Jan 4.
PMID: 26725977

Site-Specific Immunomodulator: A Novel Treatment for Crohn's Disease.
Bressler B, Bethel KP, Kleef R, Reynolds SL, Sutcliffe S, Mullins DW, Gunn H
Gastroenterol Res Pract. 2015;2015:231243. doi: 10.1155/2015/231243. Epub 2015 May 12.
PMID: 26064087

Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.
Clancy-Thompson E, Perekslis TJ, Croteau W, Alexander MP, Chabanet TB, Turk MJ, Huang YH, Mullins DW
Cancer Immunol Res. 2015 Aug;3(8):956-67. doi: 10.1158/2326-6066.CIR-15-0015. Epub 2015 Jun 5.
PMID: 26048575

The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells.
Jenkins MH, Croteau W, Mullins DW, Brinckerhoff CE
Matrix Biol. 2015 Oct;48:66-77. doi: 10.1016/j.matbio.2015.05.007. Epub 2015 May 16.
PMID: 25989506

CXCR3 signaling in BRAFWT melanoma increases IL-8 expression and tumorigenicity.
Jenkins MH, Brinckerhoff CE, Mullins DW
PLoS One. 2015;10(3):e0121140. doi: 10.1371/journal.pone.0121140. Epub 2015 Mar 23.
PMID: 25798946

BRAF inhibition alleviates immune suppression in murine autochthonous melanoma.
Steinberg SM, Zhang P, Malik BT, Boni A, Shabaneh TB, Byrne KT, Mullins DW, Brinckerhoff CE, Ernstoff MS, Bosenberg MW, Turk MJ
Cancer Immunol Res. 2014 Nov;2(11):1044-50. doi: 10.1158/2326-6066.CIR-14-0074. Epub 2014 Sep 2.
PMID: 25183499