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Brock C Christensen, Ph.D.

Title(s):
Assistant Professor of Community and Family Medicine
Assistant Professor of Pharmacology & Toxicology
Assistant Professor of Pharmacology and Toxicology

Department(s):
Community and Family Medicine
Pharmacology & Toxicology

Education:
Harvard University, Ph.D. 2008
University of Wisconsin - Madison, B.S. 2002

Programs:
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences

Contact Information:

Dartmouth Medical School
7650 Remsen
Hanover NH 03755

Office: Remsen 611
Phone: 603-650-1674
Fax: 603-650-1129
Email: Brock.Christensen@Dartmouth.edu


Professional Interests:

Dr. Christensen's research is focused on combining advances in molecular biology, genomics and bioinformatics with the powerful techniques of modern epidemiology and statistics to characterize epigenetic states in human health and disease. His interests include understanding relationships between epigenetic states and exposures in the context of disease susceptibility, occurrence, and progression. By investigating complex interactions between the environment and somatic epigenetic alterations in target tissues, as well as epigenetic susceptibility traits in surrogate tissues, he hopes to develop their potential translational utility for diagnostic, prognostic, and/or treatment purposes.

Rotations and Thesis Projects:

Rotation students are welcome to inquire about project opportunities.

Grant Information:

P20GM104416 (Karagas) Molecular Epidemiology COBRE
Role: Project leader: Early risk factor related epigenetic alterations in breast carcinogenesis
R01DE022772 MicroRNA related genetic variation and head and neck cancer
Role: PI
R21CA175553 MicroRNA related genetic variation in bladder cancer recurrence and survival
Role: PI

Courses Taught:

PEMM103 Introductory Applied Biostatistics with R (Course director)
QBS110 Integrative Biomedical Sciences I

Biography:

Dr. Christensen received his B.S. from the University of Wisconsin Madison in Medical Microbiology & Immunology and French in 2002, and his Ph.D. from the Program in Biological Sciences in Public Health at Harvard University in 2008. He trained as a postdoctoral research associate in molecular epidemiology of cancer at Brown University in the Department of Pathology and Laboratory Medicine. Dr. Christensen joined the faculty at Dartmouth in 2011 as an Assistant Professor in the Departments of Community and Family Medicine in the Section of Biostatistics and Epidemiology, and Pharmacology and Toxicology.


Selected Publications:

 

  • Langevin SM, Christensen BC Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis. Cancer Med 2014 Jun 2; (view details on MedLine)

  • Farzan SF, Karagas MR, Christensen BC, Li Z, Kuriger JK, Nelson HH RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer. PLoS One 2014; 9:e93602 (view details on MedLine)

  • Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 2014 Mar 26; 9 (view details on MedLine)

  • Selvakumar P, Owens TA, David JM, Petrelli NJ, Christensen BC, Lakshmikuttyamma A, Rajasekaran AK Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma. Epigenetics 2014 Apr; 9:579-86 (view details on MedLine)

  • Ung M, Ma X, Johnson KC, Christensen BC, Cheng C Effect of estrogen receptor α binding on functional DNA methylation in breast cancer. Epigenetics 2014 Apr; 9:523-32 (view details on MedLine)

  • Johnson KC, Koestler DC, Cheng C, Christensen BC Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics 2014 Feb; 9:268-75 (view details on MedLine)

  • Humphries LA, Godbersen JC, Danilova OV, Kaur P, Christensen BC, Danilov AV Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia. Br J Haematol 2013 Dec; 163:590-602 (view details on MedLine)

  • Wilhelm-Benartzi CS, Koestler DC, Karagas MR, Flanagan JM, Christensen BC, Kelsey KT, Marsit CJ, Houseman EA, Brown R Review of processing and analysis methods for DNA methylation array data. Br J Cancer 2013 Sep; 109:1394-402 (view details on MedLine)

  • Koestler DC, Christensen B, Karagas MR, Marsit CJ, Langevin SM, Kelsey KT, Wiencke JK, Houseman EA Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis. Epigenetics 2013 Aug; 8:816-26 (view details on MedLine)

  • Langevin SM, Michaud DS, Marsit CJ, Nelson HH, Birnbaum AE, Eliot M, Christensen BC, McClean MD, Kelsey KT Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2013 Jun; 22:1061-8 (view details on MedLine)