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Brock C Christensen, Ph.D.

Title(s):
Assistant Professor of Community and Family Medicine

Department(s):
Community and Family Medicine

Education:
Harvard University, Ph.D. 2008
University of Wisconsin - Madison, B.S. 2002

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

Dartmouth Medical School
7650 Remsen
Hanover NH 03755

Office: Remsen 611
Phone: 603-650-1674
Fax: 603-650-1129
Email: Brock.Clarke.Christensen@Dartmouth.edu


Professional Interests:

Dr. Christensen's research is focused on combining advances in molecular biology, genomics and bioinformatics with the powerful techniques of modern epidemiology and statistics to characterize epigenetic states in human health and disease. His interests include understanding relationships between epigenetic states and exposures in the context of disease susceptibility, occurrence, and progression. By investigating complex interactions between the environment and somatic epigenetic alterations in target tissues, as well as epigenetic susceptibility traits in surrogate tissues, he hopes to develop their potential translational utility for diagnostic, prognostic, and/or treatment purposes.


Selected Publications:

 

Farzan SF, Karagas MR, Christensen BC, Li Z, Kuriger JK, Nelson HH
RNASEL and MIR146A SNP-SNP Interaction as a Susceptibility Factor for Non-Melanoma Skin Cancer.
PLoS One 2014; 9(4):e93602
PMID: 24699816

Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT
Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.
Epigenetics 2014 Mar 26; 9(6)
PMID: 24671036

Selvakumar P, Owens TA, David JM, Petrelli NJ, Christensen BC, Lakshmikuttyamma A, Rajasekaran AK
Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.
Epigenetics 2014 Jan 22; 9(4)
PMID: 24452105

Ung M, Ma X, Johnson KC, Christensen BC, Cheng C
Effect of estrogen receptor α binding on functional DNA methylation in breast cancer.
Epigenetics 2014 Jan 16; 9(4)
PMID: 24434785

Johnson KC, Koestler DC, Cheng C, Christensen BC
Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation.
Epigenetics 2014 Feb 1; 9(2):268-75
PMID: 24196486

Humphries LA, Godbersen JC, Danilova OV, Kaur P, Christensen BC, Danilov AV
Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia.
Br J Haematol 2013 Dec; 163(5):590-602
PMID: 24117128

Wilhelm-Benartzi CS, Koestler DC, Karagas MR, Flanagan JM, Christensen BC, Kelsey KT, Marsit CJ, Houseman EA, Brown R
Review of processing and analysis methods for DNA methylation array data.
Br J Cancer 2013 Sep 17; 109(6):1394-402
PMID: 23982603

Koestler DC, Christensen B, Karagas MR, Marsit CJ, Langevin SM, Kelsey KT, Wiencke JK, Houseman EA
Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.
Epigenetics 2013 Aug; 8(8):816-26
PMID: 23903776

Langevin SM, Michaud DS, Marsit CJ, Nelson HH, Birnbaum AE, Eliot M, Christensen BC, McClean MD, Kelsey KT
Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma.
Cancer Epidemiol Biomarkers Prev 2013 Jun; 22(6):1061-8
PMID: 23703970

Koestler DC, Christensen BC, Marsit CJ, Kelsey KT, Houseman EA
Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures.
Stat Appl Genet Mol Biol 2013 Mar 5; 12(2):225-40
PMID: 23468465