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Paul E Holtzheimer, M.D., M.S.

Title(s):
Associate Professor of Psychiatry
Associate Professor of Surgery

Department(s):
Psychiatry
Surgery

Education:
1990-1995 Pacific Lutheran University, Tacoma, WA.
B.S., Biology, summa cum laude.
B.A., Psychology and Philosophy, summa cum laude.
- Honors in Philosophy.
- Honors in the Integrated Studies Program.
1995-1999 Dartmouth Medical School, Hanover, NH.
M.D., with honors.
2005-2008 Emory University, Atlanta, GA.
M.S., Clinical Research.

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

Dartmouth-Hitchcock Medical Center
5D
One Medical Center Drive
Lebanon NH 03756

Office: 603-650-4914
Phone: 603-650-0438
Email: Paul.E.Holtzheimer@hitchcock.org


Professional Interests:

Dr. Holtzheimerís research program at Dartmouth is focused on the neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation.

Grant Information:

2011-2016 R01 MH091100-A1 (PI: Paul Holtzheimer, MD)

Biography:

Paul Holtzheimer, MD, is Associate Professor of Psychiatry and Surgery and Director of the Mood Disorders Service at Dartmouth Medical School and Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire. He is a Diplomate of the American Board of Psychiatry and Neurology.

Dr. Holtzheimer attended Pacific Lutheran University where he graduated summa cum laude with a B.S. in Biology and B.A. in Philosophy and Psychology. He then attended Dartmouth Medical School from 1995 to 1999, graduating with honors. He completed his psychiatry residency at the University of Washington School of Medicine in 2003 followed by a clinical research fellowship in transcranial magnetic stimulation from 2003 to 2004. He joined the faculty of the Department of Psychiatry and Behavioral Sciences at the Emory University School of Medicine in 2004 where he developed further expertise in treatment-resistant mood disorders, brain imaging techniques and brain stimulation therapies (such as transcranial magnetic stimulation [TMS], electroconvulsive therapy [ECT], and deep brain stimulation [DBS]). Dr. Holtzheimer directed the Resident Psychopharmacology Clinic from 2008 to 2011.

Dr. Holtzheimerís research program at Dartmouth is focused on the neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation. Dr. Holtzheimer is faculty in the Neurosciences Division of the Program in Experimental and Molecular Medicine (PEMM). Clinically, Dr. Holtzheimer provides evaluation and consultation for patients with treatment-resistant mood disorders.

Dr. Holtzheimer is an author on over 70 publications in psychiatry, neurosurgery and neuroimaging. He has been an investigator on several clinical trials of novel treatments for mood disorders, including transcranial magnetic stimulation and deep brain stimulation, as well as numerous studies investigating the structural and functional neuroanatomy of mood disorders. He is an Associate Member of the American College of Neuropsychopharmacology where he serves on the Liaison Committee and the Membership Task Force; he also serves as a mentor for the Travel Awardee program. He is a member of the Society of Biological Psychiatry where he currently serves on the Program Committee and the Education Task Force, and is mentor for the Mentor/Mentee Program. He is also a member of the American College of Psychiatrists, the International Society for Electroconvulsive Therapy and Neurostimulation and the Society for Neuroscience.


Selected Publications:

 

  • Holtzheimer PE 3rd, Roberts DW, Darcey TM. Magnetic resonance imaging versus computed tomography for target localization in functional stereotactic neurosurgery. Neurosurgery. 1999 Aug;45(2):290-7; discussion 297-8. (view details on MedLine)

  • Holtzheimer PE 3rd, Russo J, Avery DH. A meta-analysis of repetitive transcranial magnetic stimulation in the treatment of depression. Psychopharmacol Bull. 2001 Autumn;35(4):149-69. Erratum in: Psychopharmacol Bull. 2003 Spring;37(2):5. (view details on MedLine)

  • Gutman DA, Holtzheimer PE, Behrens TE, Johansen-Berg H, Mayberg HS. A tractography analysis of two deep brain stimulation white matter targets for depression. Biol Psychiatry. 2009 Feb 15;65(4):276-82. Epub 2008 Nov 14. (view details on MedLine)

  • James GA, Kelley ME, Craddock RC, Holtzheimer PE, Dunlop BW, Nemeroff CB, Mayberg HS, Hu XP. Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjects. Neuroimage. 2009 Apr 15;45(3):778-87. Epub 2009 Jan 7. (view details on MedLine)

  • Craddock RC, Holtzheimer PE 3rd, Hu XP, Mayberg HS. Disease state prediction from resting state functional connectivity. Magn Reson Med. 2009 Dec;62(6):1619-28. (view details on MedLine)

  • Holtzheimer PE 3rd, Mayberg HS. This role of the cingulate gyrus in depression: review and synthesis of imaging data. Cingulate Neurobiology and Disease. New York: Oxford University Press, 2009, 519-535.

  • Holtzheimer PE 3rd, McDonald WM, Mufti M, Kelley ME, Quinn S, Corso G, Epstein CM. Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression. Depress Anxiety. 2010 Oct;27(10):960-3. (view details on MedLine)

  • Holtzheimer PE, Mayberg HS. Stuck in a rut: rethinking depression and its treatment. Trends Neurosci. 2011 Jan;34(1):1-9. Epub 2010 Nov 8. (view details on MedLine)

  • Holtzheimer PE, Mayberg HS. Deep brain stimulation for psychiatric disorders. Annu Rev Neurosci. 2011;34:289-307. Review. (view details on MedLine)

  • Holtzheimer PE 3rd, Kelley ME, Gross RE, Filkowski MM, Garlow SJ,Barrocas A, Wint D, Craighead MC, Kozarsky J, Chismar R, Moreines JL, Mewes K, Riva Posse P, Gutman DA, Mayberg HS. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry 2012, in press.