Craig R Tomlinson, PhD
Assistant Professor of Medicine
Assistant Professor of Pharmacology & Toxicology
Pharmacology & Toxicology
Ph.D., University of Texas at Austin
Post-Doctoral, California Institute of Technology,
Post-Doctoral, M.D. Anderson, University of Texas
Heart and Vascular Research Center
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Departments of Medicine and Pharmacology & Toxicology
One Medical Center Drive
Lebanon NH 03756
Our laboratory is involved in (i) determining the roles of the aryl hydrocarbon receptor in adult-onset diseases and trans-generational epigenetic inheritance from in utero and direct exposures to environmental toxicants and high-fat diets, (ii) the dysregulation of gene regulation and identity of new biomarkers in pancreatic cancer, and (iii) the development of novel high-throughput genomics methods as a tool to predict the outcome of gene/environment interactions.
Rotations and Thesis Projects:
*The underlying molecular mechanism of the role of the toxicant- and fat-activated AHR in (i) obesity, (ii) heart disease, and (iii) cancer from in utero and direct exposures.
*New method development in genomics.
*Identifying new biomarkers in cancer.
Schwanekamp JA, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson CR. Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin. Biochim Biophys Acta. 2006 Aug-Sep;1759(8-9):388-402. Epub 2006 Aug 7. (view details on MedLine)
Tomlinson CR, Korc M. Squeezing data from pancreatic juice. Cancer Biol Ther. 2006 Oct;5(10):1390-1. Epub 2006 Oct 26. (view details on MedLine)
Sartor MA, Tomlinson CR, Wesselkamper SC, Sivaganesan S, Leikauf GD, Medvedovic M. Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC Bioinformatics. 2006 Dec 19;7:538. (view details on MedLine)
Heim KC, White KA, Deng D, Tomlinson CR, Moore JH, Freemantle SJ, Spinella MJ. Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. Mol Cancer. 2007 Sep 19;6:57. (view details on MedLine)
Ganguly K, Stoeger T, Wesselkamper SC, Reinhard C, Sartor MA, Medvedovic M, Tomlinson CR, Bolle I, Mason JM, Leikauf GD, Schulz H. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol Genomics. 2007 Nov 14;31(3):410-21. Epub 2007 Sep 5. (view details on MedLine)
Tsonis PA, Call MK, Grogg MW, Sartor MA, Taylor RR, Forge A, Fyffe R, Goldenberg R, Cowper-Sal-lari R, Tomlinson CR. MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt. Biochem Biophys Res Commun. 2007 Nov 3;362(4):940-5. Epub 2007 Aug 27. (view details on MedLine)
Chang X, Fan Y, Karyala S, Schwemberger S, Tomlinson CR, Sartor MA, Puga A. Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor. Mol Cell Biol. 2007 Sep;27(17):6127-39. Epub 2007 Jul 2. (view details on MedLine)
Medvedovic M, Halbleib D, Miller ML, LaDow K, Sartor MA, Tomlinson CR. Gene expression profiling of blood to predict the onset of leukemia. Blood Cells Mol Dis. 2009 Jan-Feb;42(1):64-70. Epub 2008 Oct 19. (view details on MedLine)
Trask HW, Cowper-Sal-lari R, Sartor MA, Gui J, Heath CV, Renuka J, Higgins AJ, Andrews P, Korc M, Moore JH, Tomlinson CR. Microarray analysis of cytoplasmic versus whole cell RNA reveals a considerable number of missed and false positive mRNAs. RNA. 2009 Oct;15(10):1917-28. Epub 2009 Aug 24. (view details on MedLine)
Nakamura K, Maki N, Trinh A, Trask HW, Gui J, Tomlinson CR, Tsonis PA. miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking. PLoS One. 2010 Aug 11;5(8):e12058. (view details on MedLine)