Edit Entry

Mardi A Crane-Godreau, Ph.D.

Title(s):
Assistant Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
UVM 1968 BS
Massachusettes College of Liberal Arts 1998 BA
Dartmouth Medical School 2004 PhD
Somatic Experiencing Trauma Institute 2014

Programs:
Immunology Program
Norris Cotton Cancer Center

Websites:
http://dms.dartmouth.edu/microbio/
http://www.cancer.dartmouth.edu/research/immunology/investigators.shtml

Contact Information:

630 Rubin Bldg.
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9970
Email: Margaret.A.Crane

Assistant: Ingrid Svensborn
Asst. Phone: 603-653-9128


Professional Interests:

Mucosal immunology, effects of cigarette smoke exposure on innate immune function. Neuro-endocrine-immune system function and dysfunction.

Our lab has focused on the innate immune system at the mucosal surfaces. A special interest has been to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. New research in the lab seeks to determine the role of cigarette smoke exposure in neuro-endocrine-immune system dysregulation. This has implications in a range of disease states including infection, metabolic diseases, cancer and affective disorders such as depression and anxiety.

As director of the of the DMS CSEAL Dr Crane-Godreau manages the cigarette smoke exposure facility, supporting research in cancer biology, sudden infant death syndrome, cardiovascular, endocrine and immune system pathologies.

Research in our laboratory is supported by FAMRI, the Flight Attendant Medical Research Institute.

Grant Information:

FAMRI (Flight Attendant Medical Research Institute)


Selected Publications:

 

Schmalzl L, Crane-Godreau MA, Payne P
Movement-based embodied contemplative practices: definitions and paradigms.
Front Hum Neurosci 2014; 8:205
PMID: 24782738

Payne P, Crane-Godreau MA
Meditative movement for depression and anxiety.
Front Psychiatry 2013; 4:71
PMID: 23898306

Crane-Godreau MA, Black CC, Giustini AJ, Dechen T, Ryu J, Jukosky JA, Lee HK, Bessette K, Ratcliffe NR, Hoopes PJ, Fiering S, Kelly JA, Leiter JC
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema.
Front Physiol 2013; 4:132
PMID: 23781205

Robey RB, Crane-Godreau MA
"Does sunscreen promote hypertension?" and other questions. Novel interactions between vitamin D and the renin-angiotensin axis. Focus on "The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system".
Am J Physiol Cell Physiol 2013 Jun 1; 304(11):C1040-1
PMID: 23576577

Crane-Godreau MA, Payne P
A history of second hand smoke exposure: are we asking the right questions?
Front Physiol 2013; 4:25
PMID: 23431278

Larsson L, Pehrson C, Dechen T, Crane-Godreau M
Microbiological components in mainstream and sidestream cigarette smoke.
Tob Induc Dis 2012 Aug 16; 10(1):13
PMID: 22898193

Crane-Godreau MA, Maccani MA, Eszterhas SK, Warner SL, Jukosky JA, Fiering S
Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells.
Open Immunol J 2009 Jan 1; 2:86-93
PMID: 19966927

Xia L, Crane-Godreau M, Leiter JC, Bartlett D Jr
Gestational cigarette smoke exposure and hyperthermic enhancement of laryngeal chemoreflex in rat pups.
Respir Physiol Neurobiol 2009 Feb 28; 165(2-3):161-6
PMID: 19041957

Soboll G, Crane-Godreau MA, Lyimo MA, Wira CR
Effect of oestradiol on PAMP-mediated CCL20/MIP-3 alpha production by mouse uterine epithelial cells in culture.
Immunology 2006 Jun; 118(2):185-94
PMID: 16771853

Crane-Godreau MA, Wira CR
Effects of estradiol on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 alpha and tumor necrosis factor alpha production by uterine epithelial cells in culture.
Infect Immun 2005 Jul; 73(7):4231-7
PMID: 15972514