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Mardi A Crane-Godreau, Ph.D.

Assistant Professor of Microbiology and Immunology

Microbiology and Immunology

UVM 1968 BS
Massachusettes College of Liberal Arts 1998 BA
Dartmouth Medical School 2004 PhD
Somatic Experiencing Trauma Institute 2014

Immunology Program
Norris Cotton Cancer Center


Contact Information:

HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9970
Email: Margaret.A.Crane

Assistant: Deb Shinnlinger
Asst. Phone: 603-653-9972
Asst. Email: Deborah.J.Shinnlinger@Dartmouth.edu

Professional Interests:

Mucosal immunology, effects of cigarette smoke exposure on innate immune function. Neuro-endocrine-immune system function and dysfunction.

Our lab has focused on the innate immune system at the mucosal surfaces. A special interest has been to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. New research in the lab seeks to determine the role of cigarette smoke exposure in neuro-endocrine-immune system dysregulation. This has implications in a range of disease states including infection, metabolic diseases, cancer and affective disorders such as depression and anxiety.

As director of the of the DMS CSEAL Dr Crane-Godreau manages the cigarette smoke exposure facility, supporting research in cancer biology, sudden infant death syndrome, cardiovascular, endocrine and immune system pathologies.

Research in our laboratory is supported by FAMRI, the Flight Attendant Medical Research Institute.

Grant Information:

FAMRI (Flight Attendant Medical Research Institute)

Selected Publications:


Corrigendum: Somatic Experiencing: using interoception and proprioception as core elements of trauma therapy.
Payne P, Levine PA, Crane-Godreau MA
Front Psychol. 2015;6:423. doi: 10.3389/fpsyg.2015.00423. Epub 2015 Apr 14.
PMID: 25926804

The preparatory set: a novel approach to understanding stress, trauma, and the bodymind therapies.
Payne P, Crane-Godreau MA
Front Hum Neurosci. 2015;9:178. doi: 10.3389/fnhum.2015.00178. Epub 2015 Apr 1.
PMID: 25883565

Somatic experiencing: using interoception and proprioception as core elements of trauma therapy.
Payne P, Levine PA, Crane-Godreau MA
Front Psychol. 2015;6:93. doi: 10.3389/fpsyg.2015.00093. Epub 2015 Feb 4.
PMID: 25699005

Movement-based embodied contemplative practices: definitions and paradigms.
Schmalzl L, Crane-Godreau MA, Payne P
Front Hum Neurosci. 2014;8:205. doi: 10.3389/fnhum.2014.00205. Epub 2014 Apr 14.
PMID: 24782738

Meditative movement for depression and anxiety.
Payne P, Crane-Godreau MA
Front Psychiatry. 2013;4:71. doi: 10.3389/fpsyt.2013.00071. Epub 2013 Jul 24.
PMID: 23898306

Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema.
Crane-Godreau MA, Black CC, Giustini AJ, Dechen T, Ryu J, Jukosky JA, Lee HK, Bessette K, Ratcliffe NR, Hoopes PJ, Fiering S, Kelly JA, Leiter JC
Front Physiol. 2013;4:132. doi: 10.3389/fphys.2013.00132. Epub 2013 Jun 12.
PMID: 23781205

"Does sunscreen promote hypertension?" and other questions. Novel interactions between vitamin D and the renin-angiotensin axis. Focus on "The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system".
Robey RB, Crane-Godreau MA
Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1040-1. doi: 10.1152/ajpcell.00090.2013. Epub 2013 Apr 10.
PMID: 23576577

A history of second hand smoke exposure: are we asking the right questions?
Crane-Godreau MA, Payne P
Front Physiol. 2013;4:25. doi: 10.3389/fphys.2013.00025. Epub 2013 Feb 20.
PMID: 23431278

Microbiological components in mainstream and sidestream cigarette smoke.
Larsson L, Pehrson C, Dechen T, Crane-Godreau M
Tob Induc Dis. 2012 Aug 16;10(1):13. Epub 2012 Aug 16.
PMID: 22898193

Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells.
Crane-Godreau MA, Maccani MA, Eszterhas SK, Warner SL, Jukosky JA, Fiering S
Open Immunol J. 2009 Jan 1;2:86-93.
PMID: 19966927