Mardi A Crane-Godreau, Ph.D.
Assistant Professor of Microbiology and Immunology
Microbiology and Immunology
UVM 1968 BS
Massachusettes College of Liberal Arts 1998 BA
Dartmouth Medical School 2004 PhD
Somatic Experiencing Trauma Institute 2014
Norris Cotton Cancer Center
1 Medical Center Drive
Lebanon NH 03756
Mucosal immunology, effects of cigarette smoke exposure on innate immune function. Neuro-endocrine-immune system function and dysfunction.
Our lab has focused on the innate immune system at the mucosal surfaces. A special interest has been to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. New research in the lab seeks to determine the role of cigarette smoke exposure in neuro-endocrine-immune system dysregulation. This has implications in a range of disease states including infection, metabolic diseases, cancer and affective disorders such as depression and anxiety.
As director of the of the DMS CSEAL Dr Crane-Godreau manages the cigarette smoke exposure facility, supporting research in cancer biology, sudden infant death syndrome, cardiovascular, endocrine and immune system pathologies.
Research in our laboratory is supported by FAMRI, the Flight Attendant Medical Research Institute.
FAMRI (Flight Attendant Medical Research Institute)
Corrigendum: Somatic Experiencing: using interoception and proprioception as core elements of trauma therapy.
The preparatory set: a novel approach to understanding stress, trauma, and the bodymind therapies.
Somatic experiencing: using interoception and proprioception as core elements of trauma therapy.
Movement-based embodied contemplative practices: definitions and paradigms.
Meditative movement for depression and anxiety.
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema.
"Does sunscreen promote hypertension?" and other questions. Novel interactions between vitamin D and the renin-angiotensin axis. Focus on "The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system".
A history of second hand smoke exposure: are we asking the right questions?
Microbiological components in mainstream and sidestream cigarette smoke.
Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells.