Allan Gulledge, Ph.D.
Assistant Professor of Physiology and Neurobiology
Physiology and Neurobiology
University of California, Riverside, BS 1991
University of Texas, San Antonio, PhD 2000
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Dartmouth Medical School
Dartmouth Hitchcock Medical Center, Borwell 740E
One Medical Center Drive
Lebanon NH 03756-0001
Office: Borwell 704E
Asst. Phone: 603-650-7731
Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in individual neocortical neurons under a variety of experimental conditions.
Currently we are investigating the signal transduction events initiated following exposure of neurons to chemical neuromodulators critical for normal cognition. These modulators (such as dopamine, serotonin, and acetylcholine) activate a number of receptor subtypes to initiate a variety of biochemical signaling cascades within neurons. We are conducting experiments to identify which receptors and cellular processes are activated by neuromodulators, and how these signaling systems interact to influence ongoing neuronal activity. Because there are many different cell types within the cortex, each expressing a unique combination of receptors and intracellular biochemistry, neuromodulators tend to generate cell-type specific responses. By examining how individual neuromodulators differentially regulate the activity of many types of cortical neuron, we aim to identify the functional role of modulators within the cortical circuit, and to gain insight into their contribution to cognitive function.
Rotations and Thesis Projects:
There are many fundamental aspects regarding the cellular physiology of the neocortex that remain to be discovered. Among other opportunities, students may wish to consider:
1. Identification of the molecular mechanism responsible for cholinergic excitation of neocortical and hippocampal neurons.
2. Characterization of the presynaptic release processes modified by muscarinic receptor activation.
3. Determination of the role of calcium in generating inhibitory electrical responses in central neurons.
4. Characterizing the role of neuronal morphology in synaptic integration.
5. Exploring the influence of neuromodulators on the activity of cortical interneurons.
R01-MH083806: Cholinergic signaling in cortical neurons: a unifying hypothesis
Project period: 07/11/08-06/30/12
PI: Allan Gulledge
NSF 0922631: MRI: Acquisition of a multi-photon imaging and electrophysiology rig
Project period: 08/01/2009 - 07/31/2012
PI: Allan Gulledge
NARSAD Young Investigator Award (2009): CCK-Positive Large Basket Neurons as a Source of Cortical Activation in ADHD
Project Period: 01/01/2010 - 12/31/2012
PI: Allan Gulledge
Neuroscience Center at Dartmouth Collaborative/Translational Funding Award: Cholinergic mechanisms involved in cue discrimination
Project Period: 01/01/2008 - 01/01/2009
PI: Allan Gulledge & David Bucci
Advanced Systems Physiology (PEMM 271)
Medical Neuroscience (MDED 115)
Cardiovascular and Respiratory Physiology (PHSL.110)
Graduate Ethics Course (Ethics in Science) (UNSG.100.04)
Dr. Gulledge received his B.S. in Psychobiology from the University of California, Riverside in 1991, and his Ph.D. in Biology from the University of Texas, San Antonio in 2000. He then conducted postdoctoral research at the Australian National University (2000-2005) as an NSF International Research Fellow, and at the National Institute for Physiological Sciences in Okazaki, Japan (2005-2007), as a JSPS Postdoctoral Fellow. Dr. Gulledge joined the faculty of Dartmouth Medical School as an Assistant Professor of Physiology in 2007.
Dasari S, Abramowitz J, Birnbaumer L, Gulledge AT
Gulledge AT, Carnevale NT, Stuart GJ
Avesar D, Gulledge AT
Kubota Y, Karube F, Nomura M, Gulledge AT, Mochizuki A, Schertel A, Kawaguchi Y
Puig MV, Gulledge AT
Dasari S, Gulledge AT
Gulledge AT, Bucci DJ, Zhang SS, Matsui M, Yeh HH
Gulledge AT, Kawaguchi Y
Gulledge AT, Park SB, Kawaguchi Y, Stuart GJ
Gulledge AT, Stuart GJ