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Lorenzo F Sempere, Ph.D.

Title(s):
Research Assistant Professor of Medicine

Department(s):
Medicine

Education:
2004 Ph.D in Genetics at Dartmouth Medical School, NH, USA.
1999 Bachelor of Science at University Miguel Hernandez, Elche, Spain.

Contact Information:

Email: Lorenzo.F.Sempere@Dartmouth.EDU

Biography:

Dr. Sempere is currently a Research Assistant Professor of Medicine at Dartmouth-Hitchcock Medical Center. Dr. Sempere received his PhD in Genetics in the laboratory of Dr. Victor Ambros at Dartmouth Medical School, where he continued to complete postdoctoral training in the laboratory of Dr. Charles Cole in Department of Biochemistry. Early work of Dr. Sempere focused on the characterization of temporal expression patterns of microRNAs at evolutionary and organismic scales to gain insight into developmental roles of microRNAs in animals. Recent work of Dr. Sempere focuses on the characterization of spatial expression patterns of microRNAs in model organisms and clinical specimens aimed at understanding the etiological contribution of microRNAs to cancer and other human diseases.

Selected Publications:
 

Sempere LF, Korc M
A method for conducting highly sensitive microRNA in situ hybridization and immunohistochemical analysis in pancreatic cancer.
Methods Mol Biol 2013; 980:43-59
PMID: 23359149

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J
ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.
Cancer Res 2013 Jan 15; 73(2):1020-30
PMID: 23243027

Cubillos-Ruiz JR, Sempere LF, Conejo-Garcia JR
Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles.
Oncoimmunology 2012 Sep 1; 1(6):968-970
PMID: 23162774

Sempere LF
Recent advances in miRNA-based diagnostic applications.
Expert Rev Mol Diagn 2012 Jul; 12(6):557-9
PMID: 22845475

Cubillos-Ruiz JR, Baird JR, Tesone AJ, Rutkowski MR, Scarlett UK, Camposeco-Jacobs AL, Anadon-Arnillas J, Harwood NM, Korc M, Fiering SN, Sempere LF, Conejo-Garcia JR
Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.
Cancer Res 2012 Apr 1; 72(7):1683-93
PMID: 22307839

Sempere LF
Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer.
Expert Rev Mol Diagn 2011 Nov; 11(8):813-27
PMID: 22022944

Preis M, Gardner TB, Gordon SR, Pipas JM, Mackenzie TA, Klein EE, Longnecker DS, Gutmann EJ, Sempere LF, Korc M
MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma.
Clin Cancer Res 2011 Sep 1; 17(17):5812-21
PMID: 21652542

Sempere LF, Gunn JR, Korc M
A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells.
Cancer Biol Ther 2011 Aug 1; 12(3):198-207
PMID: 21613822

Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E
Involvement of microRNAs in lung cancer biology and therapy.
Transl Res 2011 Apr; 157(4):200-8
PMID: 21420030

Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M
Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.
Clin Cancer Res 2010 Aug 15; 16(16):4246-55
PMID: 20682703