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Tim Lahey, M.D.

Title(s):
Associate Professor of Medicine
Associate Professor of Microbiology and Immunology

Department(s):
Medicine
Microbiology and Immunology

Education:
AB, Georgetown University, 1990
MD, Duke University, 1998
MMSc, Harvard Medical School, 2007
Medicine Residency, University of Utah, 1998-2001
Chief Resident, University of Utah, 2001-2002
ID Fellowship, Beth Israel Deaconess MC, 2002-2005
Research Fellowship, Massachusetts General Hosp, 2003-2005

Programs:
Program in Experimental and Molecular Medicine

Curriculum Vitae:
Lahey_T_CV_2012-02-14.pdf

NIH Biosketch:
Lahey_T_BIO_2012-02-15.pdf

Websites:
https://tim-lahey.squarespace.com

Contact Information:

Infectious Diseases & Int'l Health
One Medical Center Drive
Lebanon NH 03756

Office: (603) 650-6063
Fax: (603) 650-6199
Email: Timothy.Lahey@Dartmouth.edu

Assistant: Diane Kiernan


Professional Interests:

HIV/Tuberculosis Immunology. Through the Dar Dar Trial, the largest trial of a TB vaccine candidate in the world to date, we have analyzed how spontaneous and vaccine-mediated immune responses protect HIV-infected adults from TB.

Mucosal transmission of HIV. We have investigated how semen protects target cells from HIV infection by modulating T cell receptor expression via modulation of cell surface expression of HIV receptor and co-receptors, thereby shaping the tropism of the transmitted virus. We have also found that semen has a profound anti-inflammatory effect on CD4+ T cells. Furthermore, in collaboration with the Wira lab at Dartmouth, we have studied how endogenous microbicides in cervicovaginal fluids protect women from HIV transmission to target cells.

Immunology of regulatory T cells during HIV infection. We have examined the role of regulatory T cell-associated costimulatory molecule interactions in modulating HIV-specific T cell responses and susceptibility to cell death, and the role of regulatory T cells in protecting CD4+ target cells from HIV infection.



Rotations and Thesis Projects:

Thesis project: "Semen Protects CD4+ T cells from HIV infection," Emmanuel Balandya, MD, Fogarty Fellow, PhD 2012 --> post-doc at Harvard Medical School.

Grant Information:

1. PI, Mentored Clinical Scientist Development Award 1K08AI069915-01, "Mechanisms of Regulatory T cell Mediated Suppression of HIV-specific Cellular Immunity," 2006-2011

2. Subproject director, NCRR Centers of Biomedical Research Excellence, 5P20RR016437-08, "Center for Molecular, Cellular, and Translational Immunological Research," 2009-present.

3. PI, Hitchcock Foundation Henry Heyl Award 2005

4. PI, Infectious Diseases Society of America ERF/NFID Astellas Young Investigator Award 2007

5. Co-PI, Strategy 4 grant for Translational HIV/TB Research Specimen Repository

6. PI, Hitchcock Foundation Research Grant 2010 "Semen protects CD4+ T cells from HIV infection"

7. PI, Campbell Foundation grant 2010 "Semen protects CD4+ T cells from HIV infection"

Courses Taught:

Scientific Basis of Medicine - Infectious Diseases, course director
Advanced Medical Sciences, course director
Infectious Diseases Elective, clerkship director

Medical Pharmacology
Medical Microbiology
Ethics sessions, On Doctoring
Intro to Clinical Ethics
Dartmouth Community Medical School
Virology (undergraduate)
Immunology (undergraduate)
Human Biology (undergraduate)

Biography:

Tim Lahey is an HIV and infectious diseases doctor, the chair of clinical ethics committee at Dartmouth-Hitchcock Medical Center, and a clinical immunologist with a focus on HIV transmission and tuberculosis vaccines.

Tim studied at Georgetown University, Duke University School of Medicine, and Harvard Medical School and completed clinical and research training at LDS Hospital and the University of Utah, Beth Israel Deaconess Medical Center, and the Massachusetts General Hospital including the Partners AIDS Research Center.

Tim is the project leader for the Geisel Curriculum Redesign of 2011-2019 as well as co-director for the Ethics & Humanities Working Group. In addition to directing the SBM Infectious Diseases and Advanced Medical Sciences courses, Tim runs the Clinical Infectious Diseases Elective, co-directs the Ethics & Humanities Theme, and teaches in many other courses along with providing mentorship through the Albert Schweitzer Fellowship and Physicians for Human Rights.

Tim's teaching honors include the Clinical Science Teaching Award in 2010, Distinguished Lecturer 2011, Almy Professor's Award for Excellence in Teaching 2011, Gold Humanism Scholar 2012, and selection as graduation farewell speaker every year from 2009 to 2014.


Selected Publications:

 

Lahey T
The high costs of "free" drug samples.
Clin Transl Gastroenterol 2014 Dec 18; 5:e67
PMID: 25521040

Katz CL, Lahey TP, Campbell HT
An Ethical Framework for Global Psychiatry.
Ann Glob Health 2014 March - April; 80(2):146-151
PMID: 24976554

Nelson WA, Lahey T
The ethics of mandatory flu shots. Balancing patient protection with healthcare worker autonomy is essential.
Healthc Exec 2013 Nov-Dec; 28(6):42, 44-6
PMID: 24325037

Lahey T
The ethics of clinical research in low- and middle-income countries.
Handb Clin Neurol 2013; 118:301-13
PMID: 24182387

Lahey T, Czechura T, Crabtree S, Arbeit RD, Matee M, Horsburgh CR, MacKenzie T, Bakari M, Pallangyo K, von Reyn CF
Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during HIV-associated tuberculosis.
J Infect Dis 2013 Nov 15; 208(10):1629-33
PMID: 23908490

Lahey T, Mackenzie T, Arbeit RD, Bakari M, Mtei L, Matee M, Maro I, Horsburgh CR, Pallangyo K, von Reyn CF
Recurrent tuberculosis risk among HIV-infected adults in Tanzania with prior active tuberculosis.
Clin Infect Dis 2013 Jan; 56(1):151-8
PMID: 22972862

Balandya E, Wieland-Alter W, Sanders K, Lahey T
Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression.
Am J Reprod Immunol 2012 Oct; 68(4):322-30
PMID: 22805500

Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR
Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract.
PLoS One 2012; 7(6):e38100
PMID: 22675510

Adams LV, Kreiswirth BN, Arbeit RD, Soini H, Mtei L, Matee M, Bakari M, Lahey T, Wieland-Alter W, Shashkina E, Kurepina N, Driscoll JR, Pallangyo K, Horsburgh CR, von Reyn CF
Molecular epidemiology of HIV-associated tuberculosis in Dar es Salaam, Tanzania: strain predominance, clustering, and polyclonal disease.
J Clin Microbiol 2012 Aug; 50(8):2645-50
PMID: 22649022

von Reyn CF, Bakari M, Arbeit RD, Lahey T, Ramadhani A, Egwaga S
New vaccines for the prevention of tuberculosis in human immunodeficiency virus infection.
Int J Tuberc Lung Dis 2012 Jun; 16(6):718-23
PMID: 22507085