Tim Lahey, M.D.
Associate Professor of Medicine
Associate Professor of Microbiology and Immunology
Microbiology and Immunology
AB, Georgetown University, 1990
MD, Duke University, 1998
MMSc, Harvard Medical School, 2007
Medicine Residency, University of Utah, 1998-2001
Chief Resident, University of Utah, 2001-2002
ID Fellowship, Beth Israel Deaconess MC, 2002-2005
Research Fellowship, Massachusetts General Hosp, 2003-2005
Program in Experimental and Molecular Medicine
Infectious Diseases & Int'l Health
One Medical Center Drive
Lebanon NH 03756
Office: (603) 650-6063
Fax: (603) 650-6199
Assistant: Diane Kiernan
HIV/Tuberculosis Immunology. Through the Dar Dar Trial, the largest trial of a TB vaccine candidate in the world to date, we have analyzed how spontaneous and vaccine-mediated immune responses protect HIV-infected adults from TB.
Mucosal transmission of HIV. We have investigated how semen protects target cells from HIV infection by modulating T cell receptor expression via modulation of cell surface expression of HIV receptor and co-receptors, thereby shaping the tropism of the transmitted virus. We have also found that semen has a profound anti-inflammatory effect on CD4+ T cells. Furthermore, in collaboration with the Wira lab at Dartmouth, we have studied how endogenous microbicides in cervicovaginal fluids protect women from HIV transmission to target cells.
Immunology of regulatory T cells during HIV infection. We have examined the role of regulatory T cell-associated costimulatory molecule interactions in modulating HIV-specific T cell responses and susceptibility to cell death, and the role of regulatory T cells in protecting CD4+ target cells from HIV infection.
Rotations and Thesis Projects:
Thesis project: "Semen Protects CD4+ T cells from HIV infection," Emmanuel Balandya, MD, Fogarty Fellow, PhD 2012 --> post-doc at Harvard Medical School.
1. PI, Mentored Clinical Scientist Development Award 1K08AI069915-01, "Mechanisms of Regulatory T cell Mediated Suppression of HIV-specific Cellular Immunity," 2006-2011
2. Subproject director, NCRR Centers of Biomedical Research Excellence, 5P20RR016437-08, "Center for Molecular, Cellular, and Translational Immunological Research," 2009-present.
3. PI, Hitchcock Foundation Henry Heyl Award 2005
4. PI, Infectious Diseases Society of America ERF/NFID Astellas Young Investigator Award 2007
5. Co-PI, Strategy 4 grant for Translational HIV/TB Research Specimen Repository
6. PI, Hitchcock Foundation Research Grant 2010 "Semen protects CD4+ T cells from HIV infection"
7. PI, Campbell Foundation grant 2010 "Semen protects CD4+ T cells from HIV infection"
Scientific Basis of Medicine - Infectious Diseases, course director
Advanced Medical Sciences, course director
Infectious Diseases Elective, clerkship director
Ethics sessions, On Doctoring
Intro to Clinical Ethics
Dartmouth Community Medical School
Human Biology (undergraduate)
2007 Infectious Disease Society of America ERF/NFID Astellas Young Investigator Award
2009 Farewell Speaker, elected by Dartmouth Medical School Class of 2009
2009 Distinguished Lecturer, elected by Dartmouth Medical School Class of 2011
2010 Clinical Science Teaching Award, elected by Dartmouth Medical School Class of 2010
2010 Farewell Speaker, elected by Dartmouth Medical School Class of 2010
2011 Induction into Alpha Omega Alpha Honor Society
2011 Farewell Speaker, elected by Dartmouth Medical School Class of 2011
2011 Almy Professorĺs Award for Excellence in Teaching
2011 Clinical Medicine Lecturer of the Year, Franklin Pierce PA School
Nelson WA, Lahey T
Lahey T, Czechura T, Crabtree S, Arbeit RD, Matee M, Horsburgh CR, MacKenzie T, Bakari M, Pallangyo K, von Reyn CF
Lahey T, Mackenzie T, Arbeit RD, Bakari M, Mtei L, Matee M, Maro I, Horsburgh CR, Pallangyo K, von Reyn CF
Balandya E, Wieland-Alter W, Sanders K, Lahey T
Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR
Adams LV, Kreiswirth BN, Arbeit RD, Soini H, Mtei L, Matee M, Bakari M, Lahey T, Wieland-Alter W, Shashkina E, Kurepina N, Driscoll JR, Pallangyo K, Horsburgh CR, von Reyn CF
von Reyn CF, Bakari M, Arbeit RD, Lahey T, Ramadhani A, Egwaga S
Talbot E, Munseri P, Teixeira P, Matee M, Bakari M, Lahey T, von Reyn F