Edit Entry

Tim Lahey

Associate Professor of Medicine
Associate Professor of Microbiology and Immunology
Associate Professor of The Dartmouth Institute

Microbiology and Immunology
The Dartmouth Institute

AB, Georgetown University, 1990
MD, Duke University, 1998
MMSc, Harvard Medical School, 2007
Medicine Residency, University of Utah, 1998-2001
Chief Resident, University of Utah, 2001-2002
ID Fellowship, Beth Israel Deaconess MC, 2002-2005
Research Fellowship, Massachusetts General Hosp, 2003-2005



Contact Information:

Infectious Diseases & Int'l Health
One Medical Center Drive
Lebanon NH 03756

Office: (603) 650-6063
Fax: (603) 650-6199
Email: Timothy.Lahey@Dartmouth.edu

Assistant: Diane Kiernan

Professional Interests:

HIV/Tuberculosis Immunology. Through the Dar Dar Trial, the largest trial of a TB vaccine candidate in the world to date, we have analyzed how spontaneous and vaccine-mediated immune responses protect HIV-infected adults from TB.

Mucosal transmission of HIV. We have investigated how semen protects target cells from HIV infection by modulating T cell receptor expression via modulation of cell surface expression of HIV receptor and co-receptors, thereby shaping the tropism of the transmitted virus. We have also found that semen has a profound anti-inflammatory effect on CD4+ T cells. Furthermore, in collaboration with the Wira lab at Dartmouth, we have studied how endogenous microbicides in cervicovaginal fluids protect women from HIV transmission to target cells.

Immunology of regulatory T cells during HIV infection. We have examined the role of regulatory T cell-associated costimulatory molecule interactions in modulating HIV-specific T cell responses and susceptibility to cell death, and the role of regulatory T cells in protecting CD4+ target cells from HIV infection.

Rotations and Thesis Projects:

Thesis project: "Semen Protects CD4+ T cells from HIV infection," Emmanuel Balandya, MD, Fogarty Fellow, PhD 2012 --> post-doc at Harvard Medical School.

Grant Information:

1. PI, Mentored Clinical Scientist Development Award 1K08AI069915-01, "Mechanisms of Regulatory T cell Mediated Suppression of HIV-specific Cellular Immunity," 2006-2011

2. Subproject director, NCRR Centers of Biomedical Research Excellence, 5P20RR016437-08, "Center for Molecular, Cellular, and Translational Immunological Research," 2009-present.

3. PI, Hitchcock Foundation Henry Heyl Award 2005

4. PI, Infectious Diseases Society of America ERF/NFID Astellas Young Investigator Award 2007

5. Co-PI, Strategy 4 grant for Translational HIV/TB Research Specimen Repository

6. PI, Hitchcock Foundation Research Grant 2010 "Semen protects CD4+ T cells from HIV infection"

7. PI, Campbell Foundation grant 2010 "Semen protects CD4+ T cells from HIV infection"

8. Co-PI, SYNERGY CTSA grant on ethnography of study subject attitudes regarding participation in a TB vaccine trial with anthropologist Sienna Craig, PhD

Courses Taught:

Medical students:
Scientific Basis of Medicine - Infectious Diseases, course director
Advanced Medical Sciences, course director
Infectious Diseases Elective, elective director
Virology, two sessions
On Doctoring, two sessions
Intro to Clinical Experience, one session

HIV through a Biosocial Lens: 30 Years of a Modern Plague, co-course director with anthropologist Sienna Craig, PhD
Microbiology, single session


Tim Lahey is an HIV and infectious diseases doctor, the chair of clinical ethics committee at Dartmouth-Hitchcock Medical Center, and a clinical immunologist with a focus on HIV transmission and tuberculosis vaccines.

Tim studied at Georgetown University, Duke University School of Medicine, and Harvard Medical School and completed clinical and research training at LDS Hospital and the University of Utah, Beth Israel Deaconess Medical Center, and the Massachusetts General Hospital including the Partners AIDS Research Center.

Tim is Director of Education at The Dartmouth Institute for Health Policy & Clinical Practice. At Dartmouth's Geisel School of Medicine, Tim directs the second year course SBM Infectious Diseases, the fourth year course Advanced Medical Sciences, co-directs the ethics and humanities theme, and runs the Clinical Infectious Diseases Elective. He helps lead the Albert Schweitzer Fellowship and Physicians for Human Rights and was the 2015-2016 chair of the Geisel Academy of Master Educators.

Tim's teaching honors include the Clinical Science Teaching Award in 2010, Distinguished Lecturer 2011, Almy Professor's Award for Excellence in Teaching 2011, Gold Humanism Scholar 2012, and selection as graduation farewell speaker every year from 2009 to 2015.

Selected Publications:


A proposed nationwide reporting system to satisfy the ethical obligation to prevent drug diversion-related transmission of hepatitis C in healthcare facilities.
Lahey T, Nelson WA
Clin Infect Dis. 2015 Jun 15;60(12):1816-20. doi: 10.1093/cid/civ203. Epub 2015 Mar 12.
PMID: 25767254

The high costs of "free" drug samples.
Lahey T
Clin Transl Gastroenterol. 2014 Dec 18;5:e67. doi: 10.1038/ctg.2014.16. Epub 2014 Dec 18.
PMID: 25521040

An ethical framework for global psychiatry.
Katz CL, Lahey TP, Campbell HT
Ann Glob Health. 2014 Mar-Apr;80(2):146-51. doi: 10.1016/j.aogh.2014.04.002.
PMID: 24976554

The ethics of mandatory flu shots. Balancing patient protection with healthcare worker autonomy is essential.
Nelson WA, Lahey T
Healthc Exec. 2013 Nov-Dec;28(6):42, 44-6.
PMID: 24325037

The ethics of clinical research in low- and middle-income countries.
Lahey T
Handb Clin Neurol. 2013;118:301-13. doi: 10.1016/B978-0-444-53501-6.00025-1.
PMID: 24182387

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during HIV-associated tuberculosis.
Lahey T, Czechura T, Crabtree S, Arbeit RD, Matee M, Horsburgh CR, MacKenzie T, Bakari M, Pallangyo K, von Reyn CF
J Infect Dis. 2013 Nov 15;208(10):1629-33. doi: 10.1093/infdis/jit396. Epub 2013 Aug 1.
PMID: 23908490

Recurrent tuberculosis risk among HIV-infected adults in Tanzania with prior active tuberculosis.
Lahey T, Mackenzie T, Arbeit RD, Bakari M, Mtei L, Matee M, Maro I, Horsburgh CR, Pallangyo K, von Reyn CF
Clin Infect Dis. 2013 Jan;56(1):151-8. doi: 10.1093/cid/cis798. Epub 2012 Sep 12.
PMID: 22972862

Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression.
Balandya E, Wieland-Alter W, Sanders K, Lahey T
Am J Reprod Immunol. 2012 Oct;68(4):322-30. doi: 10.1111/j.1600-0897.2012.01176.x. Epub 2012 Jul 17.
PMID: 22805500

Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract.
Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR
PLoS One. 2012;7(6):e38100. doi: 10.1371/journal.pone.0038100. Epub 2012 Jun 4.
PMID: 22675510

Molecular epidemiology of HIV-associated tuberculosis in Dar es Salaam, Tanzania: strain predominance, clustering, and polyclonal disease.
Adams LV, Kreiswirth BN, Arbeit RD, Soini H, Mtei L, Matee M, Bakari M, Lahey T, Wieland-Alter W, Shashkina E, Kurepina N, Driscoll JR, Pallangyo K, Horsburgh CR, von Reyn CF
J Clin Microbiol. 2012 Aug;50(8):2645-50. doi: 10.1128/JCM.00624-12. Epub 2012 May 30.
PMID: 22649022