Stephen L. Lee, MD, PhD
Title(s)
Assistant Professor of Neurology
Additional Titles/Positions/Affiliations
Co-medical Director, The Parkinson Center at DHMC
Department(s)
Neurology
Education
Washington University School of Medicine, Ph.D. 1997
Washington University School of Medicine, M.D. 1997
Programs
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Websites
http:
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Contact Information
Department of Neurology
One Medical Center Drive - HB 7500
Lebanon NH 03756
Office: Neurology 3C Clinic
Phone: 603-650-8354
Fax: 603-650-6233
Email: stephen.l.lee@dartmouth.edu
Assistant: Sarah L. Braginetz
Asst. Phone: 603-650-51004
Asst. Email: sarah.l.braginetz@hitchcock.org
Professional Interests
I am interested in understanding how genetic mutations can cause Parkinson's disease and other neurological disorders. I use molecular and cellular techniques to study the effect of genetic mutations causative of disease. In the clinic, I try to identify and characterize inherited neurological disorders and conduct clinical trials that attempt to translate molecular insights into novel therapies.
Grant Information
National Science Foundation IIP-0848523
(PI: Michael Linderman)
SBIR Phase II: Biosensor Device for Recordation of Handwriting
K08 NS044298 (PI)
NIH/NINDS
Genetic Analysis of an Amish Family with Parkinsonism
Translational/Collaborative Grant (PI)
Neuroscience Center at Dartmouth
Targeting Parkinson disease genes by RNA interference: Neurochemical and neurobehavioral analysis.
Clinical Discovery Award (PI: Haines JL)
Michael J. Fox Foundation
Parkinson disease in Ohio Amish
Information and Referral Center (Co-Medical Director: Coffey DJ)
American Parkinson Disease Association
Dartmouth College Strategy 4 (Co-PI: Holmes GL)
Behavioral Core Lab
Courses Taught
Course Co-Director, Neurobiology of Disease (PEMM 211)
Lecturer, Pathophysiological Basis of Brain Diseases
Lecturer, DMS Neuroscience (ND115)
Lecturer, Genetics and Physiology of Behavior (Genetics 142 /Bio 79)
Lecturer, Experimental and Molecular Medicine I (PEMM 101)
Two weeks of twice-daily prism adaptation treatment does not improve posture or gait in Parkinson's disease: a double-blind randomized controlled trial. Lifestyle Factors and Parkinson's Disease Risk in a Rural New England Case-Control Study. Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease. Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort. Therapeutic plasma exchange as a steroid-sparing therapy in a patient with limbic encephalitis due to antibodies to voltage-gated potassium channels. Parkinson disease loci in the mid-western Amish. Time-dependent statistical and correlation properties of neural signals during handwriting. A genome-wide linkage screen in the Amish with Parkinson disease points to chromosome 6. Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes. |
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