Richard Mako Saito, Ph.D.
Associate Professor of Genetics
University of California, Los Angeles - PhD 1996
Molecular and Cellular Biology Graduate Programs
Department of Genetics/DMS
Hanover, NH 03755
Office: 720 Remsen
The goal of our studies is to identify the genes and mechanisms used to regulate cell-cycle entry in the context of normal animal development. Commonly, organogenesis requires that timing of proliferation and differentiation be coordinated between cells. Thus, cells must be able to efficiently communicate with their neighbors and respond to the signals as disruption of this process may lead to developmental defects. Deregulated cell-cycle entry may disturb normal development by producing cells with inappropriate timing or number. Additionally, abnormal progression into the cell cycle, for example by ectopic activation of either cyclin D or cyclin E, has been demonstrated to result in centrosome and mitotic spindle abnormalities followed by defects in chromosomal segregation. Of particular interest to our studies, deregulation of human Cdc14A also gives rise to centrosomal and chromosomal defects. As chromosomal aberrations are commonly associated with spontaneous abortion, birth defects and cancer, uncovering the organization of the cell-division regulatory network is crucial for our understanding of normal development.
2007-2012 NIH RO1-GM077031 "Genetic and biochemical analysis of cdc-14"
Clayton J.E., S.J.L. van den Heuvel and R.M. Saito Transcriptional control of cell-cycle quiescence during C. elegans development. Dev. Biol. 313: 603-613 (view details on MedLine)
Saito, R.M., A. Perreault, B. Peach, J.S. Satterlee and S. van den Heuvel The cdc-14 phosphatase controls developmental cell-cycle arrest in C. elegans. Nature Cell Biol. 6:777-83. (view details on MedLine)
Saito, R.M. and S. van den Heuvel Malignant worms: what cancer research can learn from C. elegans. Cancer Invest. 20:264-75 (view details on MedLine)