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Mary Jo Turk, Ph.D.

Title(s):
Associate Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Dr. Turk received her B.S. in Chemistry in 1995 from John Carroll University, and her Ph.D. in 2001, from the Department of Chemistry at Purdue University. From 2001 through September of 2004, Dr. Turk was a postoctoral research fellow in the Laboratory of Tumor Immunology at Memorial Sloan-Kettering Cancer Center in New York City. She joined the department of Immunology and Microbiology, as well as the Norris Cotton Cancer Center as an Assistant Professor in October of 2004.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Curriculum Vitae:
Turk_M_CV_2009-02-18.pdf

NIH Biosketch:
Turk_M_BIO_2009-02-18.pdf

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~turklab/
http://dms.dartmouth.edu/COBRE/

Contact Information:

One Medical Center Drive
Rubin Building 732, HB 7937
Lebanon NH 03756

Office: Rubin 732
Phone: 603-653-3549
Email: mary.jo.turk@dartmouth.edu

Asst. Phone: 603-653-9952


Professional Interests:

Research in the Turk Laboratory focuses on understanding how the immune system responds to poorly immunogenic tumors, and in using this knowledge to design effective immunotherapies against cancer.  We employ a century-old model (first discovered in 1906) known as Concomitant Tumor Immunity, whereby immunity to a progressively growing tumor is monitored by measuring growth of a secondary tumor given several days later.  Using this model, we have recently shown that, in the absence of CD4 CD25 regulatory T cells, progressively growing tumors themselves induce robust anti-tumor immunity against subsequent tumors.  In hosts with melanoma, this protection is mediated by CD8 T cells which recognize unaltered self proteins that are expressed by both melanoma cells and normal melanocytes.  These findings are intriguing because they demonstrate that tumors are able to break immunological tolerance to self proteins when regulatory T cells are disabled.  Our research goals involve elucidating the mechanisms by which tumors prime these T cell responses, devising effective strategies for blockade of regulatory T cells, and developing vaccines which will boost this inherent immunity against cancer.

http://www.dartmouth.edu/~turklab/

Courses Taught:

Bio 42
Micro/Immuno 136
DMS 111


Selected Publications:

 

Toraya-Brown S, Sheen MR, Zhang P, Chen L, Baird JR, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Nanomedicine 2014 Aug; 10(6):1273-85
PMID: 24566274

Jenkins MH, Steinberg SM, Alexander MP, Fisher JL, Ernstoff MS, Turk MJ, Mullins DW, Brinckerhoff CE
Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Pigment Cell Melanoma Res 2014 May; 27(3):495-501
PMID: 24460976

Byrne KT, Zhang P, Steinberg SM, Turk MJ
Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma.
J Immunol 2014 Feb 15; 192(4):1433-9
PMID: 24403535

Black CC, Turk MJ, Dragnev K, Rigas JR
Adenocarcinoma contains more immune tolerance regulatory t-cell lymphocytes (versus squamous carcinoma) in non-small-cell lung cancer.
Lung 2013 Jun; 191(3):265-70
PMID: 23494387

Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.
J Immunol 2013 Jan 1; 190(1):469-78
PMID: 23225891

Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S
Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.
Integr Biol (Camb) 2013 Jan; 5(1):159-71
PMID: 22935885

Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ
A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.
Cancer Res 2012 Oct 15; 72(20):5230-9
PMID: 22902413

Cote AL, Byrne KT, Steinberg SM, Zhang P, Turk MJ
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
PLoS One 2011; 6(10):e26491
PMID: 22046294

Byrne KT, Turk MJ
New perspectives on the role of vitiligo in immune responses to melanoma.
Oncotarget 2011 Sep; 2(9):684-94
PMID: 21911918

Byrne KT, Cote AL, Zhang P, Steinberg SM, Guo Y, Allie R, Zhang W, Ernstoff MS, Usherwood EJ, Turk MJ
Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma.
J Clin Invest 2011 May; 121(5):1797-809
PMID: 21540555