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Brent L Berwin, Ph.D.

Associate Professor of Microbiology and Immunology

Microbiology and Immunology

University of Wisconsin-Madison, Ph.D., 1999
Lewis & Clark College, B.S., 1991

Dr. Berwin graduated from the University of Wisconsin-Madison in 1999. He did his postdoc training at Duke University and joined Dartmouth Medical School in the fall of 2004. Dr. Berwin is an Associate Professor in the Department of Microbiology and Immunology.

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center


Contact Information:

Dartmouth Medical Center
1 Medical Center Dr.
HB 7556 - Rm. 614W
Lebanon NH 03756

Phone: 603-650-6899
Fax: 603-650-6223
Email: berwin@dartmouth.edu

Selected Publications:


Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Mol Ther Methods Clin Dev 2015; 2:15021
PMID: 26151066

Shepardson KM, Jhingran A, Caffrey A, Obar JJ, Suratt BT, Berwin BL, Hohl TM, Cramer RA
Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.
PLoS Pathog 2014 Sep; 10(9):e1004378
PMID: 25255025

Torres IM, Patankar YR, Shabaneh TB, Dolben E, Hogan DA, Leib DA, Berwin BL
Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection.
Infect Immun 2014 Nov; 82(11):4689-97
PMID: 25156732

Hart KM, Usherwood EJ, Berwin BL
CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.
Immunol Cell Biol 2014 Jul; 92(6):499-508
PMID: 24613975

Lovewell RR, Hayes SM, O'Toole GA, Berwin B
Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment.
Am J Physiol Lung Cell Mol Physiol 2014 Apr 1; 306(7):L698-707
PMID: 24487390

Lovewell RR, Patankar YR, Berwin B
Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa.
Am J Physiol Lung Cell Mol Physiol 2014 Apr 1; 306(7):L591-603
PMID: 24464809

Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY
Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.
Arterioscler Thromb Vasc Biol 2013 Sep; 33(9):2081-7
PMID: 23846496

Patankar YR, Lovewell RR, Poynter ME, Jyot J, Kazmierczak BI, Berwin B
Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa.
Infect Immun 2013 Jun; 81(6):2043-52
PMID: 23529619

Lovewell RR, Collins RM, Acker JL, O'Toole GA, Wargo MJ, Berwin B
Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion.
PLoS Pathog 2011 Sep; 7(9):e1002253
PMID: 21949654

Hart KM, Byrne KT, Molloy MJ, Usherwood EM, Berwin B
IL-10 immunomodulation of myeloid cells regulates a murine model of ovarian cancer.
Front Immunol 2011; 2:29
PMID: 22566819