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Deborah A Hogan, PhD

Professor of Microbiology and Immunology

Microbiology and Immunology

Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.


Contact Information:

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318
Email: Deborah.A.Hogan@Dartmouth.edu

Professional Interests:


The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.

For more information, please visit the Hogan Lab Home Page (www.dartmouth.edu/~hoganlab).

Selected Publications:


<i>Pseudomonas aeruginosa</i> Alginate Overproduction Promotes Coexistence with <i>Staphylococcus aureus</i> in a Model of Cystic Fibrosis Respiratory Infection.
Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR Jr, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB
MBio. 2017 Mar 21;8(2) pii: e00186-17. doi: 10.1128/mBio.00186-17. Epub 2017 Mar 21.
PMID: 28325763

Global Role of Cyclic AMP Signaling in pH-Dependent Responses in <i>Candida albicans</i>.
Hollomon JM, Grahl N, Willger SD, Koeppen K, Hogan DA
mSphere. 2016 Nov-Dec;1(6) pii: e00283-16. Epub 2016 Nov 30.
PMID: 27921082

ADAGE-Based Integration of Publicly Available <i>Pseudomonas aeruginosa</i> Gene Expression Data with Denoising Autoencoders Illuminates Microbe-Host Interactions.
Tan J, Hammond JH, Hogan DA, Greene CS
mSystems. 2016 Jan-Feb;1(1) pii: e00025-15. Epub 2016 Jan 19.
PMID: 27822512

Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.
Xie JL, Grahl N, Sless T, Leach MD, Kim SH, Hogan DA, Robbins N, Cowen LE
PLoS Genet. 2016 Oct;12(10):e1006405. doi: 10.1371/journal.pgen.1006405. Epub 2016 Oct 27.
PMID: 27788136

Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers.
Hammond JH, Hebert WP, Naimie A, Ray K, Van Gelder RD, DiGiandomenico A, Lalitha P, Srinivasan M, Acharya NR, Lietman T, Hogan DA, Zegans ME
mSphere. 2016 Sep-Oct;1(5) pii: e00140-16. doi: 10.1128/mSphere.00140-16. Epub 2016 Sep 7.
PMID: 27631025

Use of a Multiplex Transcript Method for Analysis of Pseudomonas aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung.
Gifford AH, Willger SD, Dolben EL, Moulton LA, Dorman DB, Bean H, Hill JE, Hampton TH, Ashare A, Hogan DA
Infect Immun. 2016 Oct;84(10):2995-3006. doi: 10.1128/IAI.00437-16. Epub 2016 Sep 19.
PMID: 27481238

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.
Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA
PLoS Pathog. 2016 Jun;12(6):e1005672. doi: 10.1371/journal.ppat.1005672. Epub 2016 Jun 13.
PMID: 27295279

The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development.
Sakhtah H, Koyama L, Zhang Y, Morales DK, Fields BL, Price-Whelan A, Hogan DA, Shepard K, Dietrich LE
Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3538-47. doi: 10.1073/pnas.1600424113. Epub 2016 Jun 6.
PMID: 27274079

Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease.
Hogan DA, Willger SD, Dolben EL, Hampton TH, Stanton BA, Morrison HG, Sogin ML, Czum J, Ashare A
PLoS One. 2016;11(3):e0149998. doi: 10.1371/journal.pone.0149998. Epub 2016 Mar 4.
PMID: 26943329

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways.
Grahl N, Demers EG, Lindsay AK, Harty CE, Willger SD, Piispanen AE, Hogan DA
PLoS Pathog. 2015 Aug;11(8):e1005133. doi: 10.1371/journal.ppat.1005133. Epub 2015 Aug 28.
PMID: 26317337