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Deborah A Hogan, Ph.D.

Associate Professor of Microbiology and Immunology

Microbiology and Immunology

Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.

National Center for Disaster Mental Health Research


Contact Information:

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318
Email: Deborah.A.Hogan@Dartmouth.edu

Professional Interests:


The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.

For more information, please visit the Hogan Lab Home Page (www.dartmouth.edu/~hoganlab).

Selected Publications:


Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways.
Grahl N, Demers EG, Lindsay AK, Harty CE, Willger SD, Piispanen AE, Hogan DA
PLoS Pathog. 2015 Aug;11(8):e1005133. doi: 10.1371/journal.ppat.1005133. Epub 2015 Aug 28.
PMID: 26317337

Editorial overview: Host-microbe interactions: fungi: Heterogeneity in fungal cells, populations, and communities.
Hogan DA, Gladfelter AS
Curr Opin Microbiol. 2015 Aug;26:vii-ix. doi: 10.1016/j.mib.2015.07.003. Epub 2015 Jul 20.
PMID: 26205287

Links between Anr and Quorum Sensing in Pseudomonas aeruginosa Biofilms.
Hammond JH, Dolben EF, Smith TJ, Bhuju S, Hogan DA
J Bacteriol. 2015 Sep;197(17):2810-20. doi: 10.1128/JB.00182-15. Epub 2015 Jun 15.
PMID: 26078448

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Stanton BA, Coutermarsh B, Barnaby R, Hogan D
PLoS One. 2015;10(5):e0127742. doi: 10.1371/journal.pone.0127742. Epub 2015 May 27.
PMID: 26018799

Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis.
Willger SD, Grim SL, Dolben EL, Shipunova A, Hampton TH, Morrison HG, Filkins LM, O'Toole GA, Moulton LA, Ashare A, Sogin ML, Hogan DA
Microbiome. 2014;2:40. doi: 10.1186/2049-2618-2-40. Epub 2014 Nov 3.
PMID: 25408892

Candida albicans ethanol stimulates Pseudomonas aeruginosa WspR-controlled biofilm formation as part of a cyclic relationship involving phenazines.
Chen AI, Dolben EF, Okegbe C, Harty CE, Golub Y, Thao S, Ha DG, Willger SD, O'Toole GA, Harwood CS, Dietrich LE, Hogan DA
PLoS Pathog. 2014 Oct;10(10):e1004480. doi: 10.1371/journal.ppat.1004480. Epub 2014 Oct 23.
PMID: 25340349

Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation.
Lindsay AK, Morales DK, Liu Z, Grahl N, Zhang A, Willger SD, Myers LC, Hogan DA
PLoS Genet. 2014 Oct;10(10):e1004567. doi: 10.1371/journal.pgen.1004567. Epub 2014 Oct 2.
PMID: 25275466

Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection.
Torres IM, Patankar YR, Shabaneh TB, Dolben E, Hogan DA, Leib DA, Berwin BL
Infect Immun. 2014 Nov;82(11):4689-97. doi: 10.1128/IAI.02024-14. Epub 2014 Aug 25.
PMID: 25156732

Global regulator Anr represses PlcH phospholipase activity in Pseudomonas aeruginosa when oxygen is limiting.
Jackson AA, Daniels EF, Hammond JH, Willger SD, Hogan DA
Microbiology. 2014 Oct;160(Pt 10):2215-25. doi: 10.1099/mic.0.081158-0. Epub 2014 Jul 29.
PMID: 25073853

The complex roles of NADPH oxidases in fungal infection.
Hogan D, Wheeler RT
Cell Microbiol. 2014 Aug;16(8):1156-67. doi: 10.1111/cmi.12320. Epub 2014 Jul 7.
PMID: 24905433