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Benjamin B Williams, Ph.D.

Title(s):
Associate Professor of Medicine
Associate Professor of Radiology

Department(s):
Medicine
Radiology

Education:
Kenyon College, Gambier, OH. B.A., Physics, 1995
University of Chicago, Chicago, IL. Ph.D., Medical Physics, 2003

Programs:
EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Websites:
http://www.dartmouth.edu/~eprctr/

Contact Information:

Hinman Box 7785
704 Vail
Hanover NH 03755

Office: Vail 704, DHMC 265I2
Phone: 603-650-1806
Email: Ben.Williams@Dartmouth.edu

Assistant: Nancy Davis
Asst. Phone: 603-650-1784
Asst. Email: Nancy.Davis@Dartmouth.edu


Professional Interests:

Tissue oxygen measurement, Small animal imaging, Image reconstruction, Biodosimetry

Grant Information:

R21 CA121593 Swartz (PI) 7/3/06 – 6/30/08
National Institutes of Health
Determination of Clinical Feasibility of EPR Oximetry of Tumors
The overall objective of these studies is to demonstrate the clinical feasibility of using in vivo EPR oximetry to obtain clinically useful information from tumors in patients.

R21 DK072112 Khan (PI) 7/1/06 – 6/30/08
National Institutes of Health
Development of EPR and NIR Oximetry for Diabetic Foot
This project will apply two emerging techniques; electron paramagnetic resonance (EPR) oximetry and near infrared spectroscopy (NIR) to measure tissue oxygenation more directly and reliably in healthy volunteers. The ultimate aim is to extend the techniques to diabetic patients for clinical management of the diabetes.

R01 CA120919 Khan (PI) 7/1/06 – 5/31/11
National Institutes of Health
Oxygen Guided Hypofractionated Radiotherapy for Gliomas
The hypothesis of this project is that the therapeutic outcome of hypofractionated radiotherapy of gliomas can be significantly enhanced if radiotherapy is used at times of optimal tumor oxygenation and the use of hyperoxic therapies in conjunction with hypofractionated radiotherapy can be optimized by the use of information on oxygen levels in the tumors.

UTAJ75_2005 Williams (PI) 9/01/05 – 8/31/07
The GEMI Fund
Electron Paramagnetic Resonance Measurements of Brain Tissue pO2
and Oxidative Stress during Hyperbaric Oxygen Therapy Following Stoke
The overall goal of this project is to use the unique capabilities of electron paramagnetic spectroscopy to study brain tissue oxygenation and free radical generation during the administration of normobaric and hyperbaric oxygen therapy.

1U19 AI067733 (Swartz, Project 3) 9/01/05 – 8/31/10
National Institutes of Health
Center Title: Center for Biophysical Assessment and Risk Management Following Irradiation
Project Title: In Vivo EPR for After-the-Fact Measurement of Dose
(Administered as a subcontract with the University of Rochester)
The overall objective of this project is to meet a critical need: determining immediately after an incident whether individuals have received a radiation dose that could result to acute clinical symptoms.

Courses Taught:

Engineering Sciences 167, Medical Imaging (MRI Lectures)


Selected Publications:

 

  • Williams BB, Hou H, Grinberg OY, Demidenko E, Swartz HM. High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat. Antioxid Redox Signal. 2007 Oct;9(10):1691-8. (view details on MedLine)

  • Khan N, Williams BB, Hou H, Li H, Swartz HM. Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies. Antioxid Redox Signal. 2007 Aug;9(8):1169-82. Review. (view details on MedLine)

  • Williams BB, Pan X, Halpern HJ. EPR imaging: the relationship between CW spectra acquired from an extended sample subjected to fixed stepped gradients and the Radon transform of the resonance density. J Magn Reson. 2005 May;174(1):88-96. (view details on MedLine)

  • Swartz HM, Burke G, Coey M, Demidenko E, Dong R, Grinberg O, Hilton J, Iwasaki A, Lesniewski P, Kmiec M, Lo K-M, Nicolalde RJ, Ruuge A, Salata Y, Sucheta A, Walczak T, Williams BB, Mitchell CA, Romanyukha A, Schauer DA. In vivo EPR for dosimetry. Radiation Measurements. 2007; 42:1075-1084.

  • Elas M, Williams BB, Parasca A, Mailer C, Pelizzari CA, Lewis MA, River JN, Karczmar GS, Barth ED, Halpern HJ. Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med. 2003 Apr;49(4):682-91. (view details on MedLine)