Yashi F Ahmed, M.D.
Associate Professor of Genetics
Duke Medical School PhD 1992, MD 1993
Molecular and Cellular Biology Graduate Programs
Department of Genetics
Hanover NH 03755
Office: Vail 604
Fax: 603 650-1188
Our research uses Drosophila as a model to study the evolutionarily conserved Wnt/Wingless signal transduction pathway, with a focus on one component in this pathway, Adenomatous polyposis coli (APC). Wnt/Wingless signaling directs cell proliferation, cell fate, and apoptotic cell death during development and is inappropriately activated in several types of cancer. The majority of colorectal carcinomas have truncating mutations in APC, a negative regulator in Wnt signaling. APC functions in a protein complex that targets the key transcriptional activator in the pathway, beta-catenin, for proteasomal degradation. Thus inactivation of APC results in ectopic Wnt signaling, and the aberrant activation of target genes. The primary goals of our research are to determine the molecular mechanisms by which APC regulates Wnt signaling, and the molecular consequences of APC loss.
Benchabane, H., Hughes, E.G., Takacs, C.M., Baird, J.R., and Ahmed, Y. Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen. Development 2008 135:963-71. (Cover Article) (view details on MedLine)
Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, and Ahmed Y. Dual positive and negative regulation of Wingless signaling by Adenomatous polyposis coli. Science 2008 319:333-336 (view details on MedLine)
Benchabane, H., and Ahmed, Y. The Adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis. In APC proteins, ed. I. Nathke and B. McCartney (Austin, TX: Landes Bioscience) 2008, in press