Michael L. Whitfield, Ph.D.
Professor of Genetics
University of North Carolina at Chapel Hill, PhD 1999
Molecular and Cellular Biology Graduate Programs
Hanover NH 03755
Office: 705 Remsen
The complexities of biological systems can now be studied with genome-wide approaches that take a global view of the underlaying biology. Biological systems can take multiple forms that range from the molecular mechanisms that function in a cell, to the regulatory networks controlling gene expression and the complex interactions that occur in whole tissue such as skin. Improper regulation and/or perturbation of the mechanisms controlling these complex systems are characteristic of many disease states. Ultimately I am interested In the regulatory mechanisms governing gene expression and in the cell biology of the human cell division cycle and the systemic autoimmune disease, scleroderma. My laboratory will pursue functional studies of novel genes identified in our genome-wide analyses in order to better understand the cell biology of these systems; antibodies have been raised against >70 novel cell cycle-regulated genes and will form the basis of initial studies.