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Richard J. Barth, MD

Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Relationship of breast MRI to recurrence rates in patients undergoing breast-conservation treatment.
Hill MV, Beeman JL, Jhala K, Holubar SD, Rosenkranz KM, Barth RJ Jr
Breast Cancer Res Treat. 2017 Jun;163(3):615-622. doi: 10.1007/s10549-017-4205-9. Epub 2017 Mar 18.
PMID: 28315967

An Educational Intervention Decreases Opioid Prescribing After General Surgical Operations.
Hill MV, Stucke RS, McMahon ML, Beeman JL, Barth RJ Jr
Ann Surg. 2017 Mar 6; doi: 10.1097/SLA.0000000000002198. Epub 2017 Mar 6.
PMID: 28267689

Wide Variation and Excessive Dosage of Opioid Prescriptions for Common General Surgical Procedures.
Hill MV, McMahon ML, Stucke RS, Barth RJ Jr
Ann Surg. 2017 Apr;265(4):709-714. doi: 10.1097/SLA.0000000000001993.
PMID: 27631771

PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer.
Qian DC, Xiao X, Byun J, Suriawinata AA, Her SC, Amos CI, Barth RJ Jr
Clin Cancer Res. 2017 Jan 15;23(2):399-406. doi: 10.1158/1078-0432.CCR-16-0623. Epub 2016 Jul 19.
PMID: 27435399

Cost-effectiveness and clinical efficacy of biliary stents in patients undergoing neoadjuvant therapy for pancreatic adenocarcinoma in a randomized controlled trial.
Gardner TB, Spangler CC, Byanova KL, Ripple GH, Rockacy MJ, Levenick JM, Smith KD, Colacchio TA, Barth RJ, Zaki BI, Tsapakos MJ, Gordon SR
Gastrointest Endosc. 2016 Sep;84(3):460-6. doi: 10.1016/j.gie.2016.02.047. Epub 2016 Mar 10.
PMID: 26972022

Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites.
Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD
Oncotarget. 2016 Mar 29;7(13):17087-102. doi: 10.18632/oncotarget.7718.
PMID: 26934555

Perioperative Bundle Decreases Postoperative Hepatic Surgery Infections.
Hill MV, Holubar SD, Garfield Legare CI, Luurtsema CM, Barth RJ Jr
Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1140-6. doi: 10.1245/s10434-015-4584-2. Epub 2015 May 14.
PMID: 25971958

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L
Proc Natl Acad Sci U S A. 2015 May 26;112(21):6682-7. doi: 10.1073/pnas.1420370112. Epub 2015 May 11.
PMID: 25964334

Nodal lymph flow quantified with afferent vessel input function allows differentiation between normal and cancer-bearing nodes.
DSouza AV, Elliott JT, Gunn JR, Barth RJ Jr, Samkoe KS, Tichauer KM, Pogue BW
Biomed Opt Express. 2015 Apr 1;6(4):1304-17. doi: 10.1364/BOE.6.001304. Epub 2015 Mar 17.
PMID: 25909014

A Pilot Study of Ultrasound-Guided Cryoablation of Invasive Ductal Carcinomas up to 15 mm With MRI Follow-Up and Subsequent Surgical Resection.
Poplack SP, Levine GM, Henry L, Wells WA, Heinemann FS, Hanna CM, Deneen DR, Tosteson TD, Barth RJ Jr
AJR Am J Roentgenol. 2015 May;204(5):1100-8. doi: 10.2214/AJR.13.12325.
PMID: 25905948