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Richard J. Barth, M.D.

Title(s):
Associate Professor of Surgery

Department(s):
Surgery

Education:
A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Programs:
Norris Cotton Cancer Center

Curriculum Vitae:
Barth_R_CV_2009-02-12.pdf

NIH Biosketch:
Barth_R_BIO_2009-02-12.pdf

Websites:
http://dms.dartmouth.edu/immuno/

Contact Information:

DHMC
1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:
 

Laughney AM, Krishnaswamy V, Rice TB, Cuccia DJ, Barth RJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues.
J Biomed Opt 2013 Mar; 18(3):036012
PMID: 23525360

McGowan MM, Eisenberg BL, Lewis LD, Froehlich HM, Wells WA, Eastman A, Kuemmerle NB, Rosenkrantz KM, Barth RJ Jr, Schwartz GN, Li Z, Tosteson TD, Beaulieu BB Jr, Kinlaw WB
A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue.
Breast Cancer Res Treat 2013 Feb; 138(1):175-83
PMID: 23417336

Davis KL, Barth RJ Jr, Gui J, Dann E, Eisenberg B, Rosenkranz K
Use of MRI in preoperative planning for women with newly diagnosed DCIS: risk or benefit?
Ann Surg Oncol 2012 Oct; 19(10):3270-4
PMID: 22911365

Laughney AM, Krishnaswamy V, Rizzo EJ, Schwab MC, Barth RJ, Pogue BW, Paulsen KD, Wells WA
Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment.
Clin Cancer Res 2012 Nov 15; 18(22):6315-25
PMID: 22908098

Gardner TB, Barth RJ, Zaki BI, Boulay BR, McGowan MM, Sutton JE, Ripple GH, Colacchio TA, Smith KD, Byock IR, Call M, Suriawinata AA, Tsapakos MJ, Mills JB, Srivastava A, Stannard M, Lisovsky M, Gordon SR, Pipas JM
Effect of initiating a multidisciplinary care clinic on access and time to treatment in patients with pancreatic adenocarcinoma.
J Oncol Pract 2010 Nov; 6(6):288-92
PMID: 21358957

Barth RJ Jr, Fisher DA, Wallace PK, Channon JY, Noelle RJ, Gui J, Ernstoff MS
A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: tumor-specific immune responses are associated with improved survival.
Clin Cancer Res 2010 Nov 15; 16(22):5548-56
PMID: 20884622

Bauman L, Barth RJ, Rosenkranz KM
Breast conservation in women with multifocal-multicentric breast cancer: is it feasible?
Ann Surg Oncol 2010 Oct; 17 Suppl 3:325-9
PMID: 20853054

Wang J, Jiang S, Li Z, diFlorio-Alexander RM, Barth RJ, Kaufman PA, Pogue BW, Paulsen KD
In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography.
Med Phys 2010 Jul; 37(7):3715-24
PMID: 20831079

Schwaab T, Schwarzer A, Wolf B, Crocenzi TS, Seigne JD, Crosby NA, Cole BF, Fisher JL, Uhlenhake JC, Mellinger D, Foster C, Szczepiorkowski ZM, Webber SM, Schned AR, Harris RD, Barth RJ Jr, Heaney JA, Noelle RJ, Ernstoff MS
Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (Interleukin 2) and IFN-{alpha}2a therapy in metastatic renal cell carcinoma patients.
Clin Cancer Res 2009 Aug 1; 15(15):4986-92
PMID: 19622576

Halter RJ, Zhou T, Meaney PM, Hartov A, Barth RJ Jr, Rosenkranz KM, Wells WA, Kogel CA, Borsic A, Rizzo EJ, Paulsen KD
The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience.
Physiol Meas 2009 Jun; 30(6):S121-36
PMID: 19491436