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Richard J. Barth, M.D.

Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K, Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR, Miller TW
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Breast Cancer Res Treat 2015 Jan; 149(1):69-79
PMID: 25491778

Muller KE, Tafe LJ, de Abreu FB, Peterson JD, Wells WA, Barth RJ, Marotti JD
Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma.
Hum Pathol 2015 Feb; 46(2):327-33
PMID: 25476122

Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW
Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.
Nat Med 2014 Nov; 20(11):1348-53
PMID: 25344739

Krishnaswamy V, Elliott JT, McClatchy DM 3rd, Barth RJ Jr, Wells WA, Pogue BW, Paulsen KD
Structured light scatteroscopy.
J Biomed Opt 2014; 19(7):070504
PMID: 25057960

Gardner TB, Hessami N, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Zaki B, Tsapakos MJ, Suriawinata AA, Putra J, Tsongalis GJ, Mody K, Gordon SR, Pipas JM
The effect of neoadjuvant chemoradiation on pancreatic cancer-associated diabetes mellitus.
Pancreas 2014 Oct; 43(7):1018-21
PMID: 25000339

Erkmen CP, Barth RJ Jr, Raman V
Case report: Successful treatment of recurrent chordoma and bilateral pulmonary metastases following an 11-year disease-free period.
Int J Surg Case Rep 2014; 5(7):424-7
PMID: 24907541

Liu X, Mody K, de Abreu FB, Pipas JM, Peterson JD, Gallagher TL, Suriawinata AA, Ripple GH, Hourdequin KC, Smith KD, Barth RJ Jr, Colacchio TA, Tsapakos MJ, Zaki BI, Gardner TB, Gordon SR, Amos CI, Wells WA, Tsongalis GJ
Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations.
Clin Chem 2014 Jul; 60(7):1004-11
PMID: 24821835

Pallone MJ, Poplack SP, Avutu HB, Paulsen KD, Barth RJ Jr
Supine breast MRI and 3D optical scanning: a novel approach to improve tumor localization for breast conserving surgery.
Ann Surg Oncol 2014 Jul; 21(7):2203-8
PMID: 24619494

Gardner TB, Glass LM, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Tsapakos MJ, Suriawinata AA, Tsongalis GJ, Pipas JM, Gordon SR
Pancreatic cyst prevalence and the risk of mucin-producing adenocarcinoma in US adults.
Am J Gastroenterol 2013 Oct; 108(10):1546-50
PMID: 24091499

Xue Y, Abou Tayoun AN, Abo KM, Pipas JM, Gordon SR, Gardner TB, Barth RJ Jr, Suriawinata AA, Tsongalis GJ
MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm.
Cancer Genet 2013 Jun; 206(6):217-21
PMID: 23933230