Richard J. Barth, MD
Professor of Surgery
A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985
Norris Cotton Cancer Center
1 Medical Center Drive
Lebanon NH 03756
This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.
Wide Variation and Excessive Dosage of Opioid Prescriptions for Common General Surgical Procedures.
PI3K/Akt/mTOR signaling and plasma membrane proteins are implicated in responsiveness to adjuvant dendritic cell vaccination for metastatic colorectal cancer.
Cost-effectiveness and clinical efficacy of biliary stents in patients undergoing neoadjuvant therapy for pancreatic adenocarcinoma in a randomized controlled trial.
Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites.
Perioperative Bundle Decreases Postoperative Hepatic Surgery Infections.
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Nodal lymph flow quantified with afferent vessel input function allows differentiation between normal and cancer-bearing nodes.
A Pilot Study of Ultrasound-Guided Cryoablation of Invasive Ductal Carcinomas up to 15 mm With MRI Follow-Up and Subsequent Surgical Resection.
Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical assessment during breast conserving surgery.
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.