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Richard J. Barth, M.D.

Associate Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Pallone MJ, Poplack SP, Avutu HB, Paulsen KD, Barth RJ Jr
Supine Breast MRI and 3D Optical Scanning: A Novel Approach to Improve Tumor Localization for Breast Conserving Surgery.
Ann Surg Oncol 2014 Mar 12;
PMID: 24619494

Gardner TB, Glass LM, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Tsapakos MJ, Suriawinata AA, Tsongalis GJ, Pipas JM, Gordon SR
Pancreatic cyst prevalence and the risk of mucin-producing adenocarcinoma in US adults.
Am J Gastroenterol 2013 Oct; 108(10):1546-50
PMID: 24091499

Xue Y, Abou Tayoun AN, Abo KM, Pipas JM, Gordon SR, Gardner TB, Barth RJ Jr, Suriawinata AA, Tsongalis GJ
MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm.
Cancer Genet 2013 Jun; 206(6):217-21
PMID: 23933230

Laughney AM, Krishnaswamy V, Rizzo EJ, Schwab MC, Barth RJ Jr, Cuccia DJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA
Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging.
Breast Cancer Res 2013 Aug 5; 15(4):R61
PMID: 23915805

Rosenkranz KM, Tsui E, McCabe EB, Gui J, Underhill K, Barth RJ Jr
Increased rates of long-term complications after MammoSite brachytherapy compared with whole breast radiation therapy.
J Am Coll Surg 2013 Sep; 217(3):497-502
PMID: 23830216

Reeves JG, Suriawinata AA, Ng DP, Holubar SD, Mills JB, Barth RJ Jr
Short-term preoperative diet modification reduces steatosis and blood loss in patients undergoing liver resection.
Surgery 2013 Nov; 154(5):1031-7
PMID: 23809869

Laughney AM, Krishnaswamy V, Rice TB, Cuccia DJ, Barth RJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues.
J Biomed Opt 2013 Mar; 18(3):036012
PMID: 23525360

McGowan MM, Eisenberg BL, Lewis LD, Froehlich HM, Wells WA, Eastman A, Kuemmerle NB, Rosenkrantz KM, Barth RJ Jr, Schwartz GN, Li Z, Tosteson TD, Beaulieu BB Jr, Kinlaw WB
A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue.
Breast Cancer Res Treat 2013 Feb; 138(1):175-83
PMID: 23417336

Davis KL, Barth RJ Jr, Gui J, Dann E, Eisenberg B, Rosenkranz K
Use of MRI in preoperative planning for women with newly diagnosed DCIS: risk or benefit?
Ann Surg Oncol 2012 Oct; 19(10):3270-4
PMID: 22911365

Laughney AM, Krishnaswamy V, Rizzo EJ, Schwab MC, Barth RJ, Pogue BW, Paulsen KD, Wells WA
Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment.
Clin Cancer Res 2012 Nov 15; 18(22):6315-25
PMID: 22908098