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Richard J. Barth, M.D.

Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Perioperative Bundle Decreases Postoperative Hepatic Surgery Infections.
Hill MV, Holubar SD, Garfield Legare CI, Luurtsema CM, Barth RJ Jr
Ann Surg Oncol. 2015 May 14; Epub 2015 May 14.
PMID: 25971958

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L
Proc Natl Acad Sci U S A. 2015 May 26;112(21):6682-7. doi: 10.1073/pnas.1420370112. Epub 2015 May 11.
PMID: 25964334

Nodal lymph flow quantified with afferent vessel input function allows differentiation between normal and cancer-bearing nodes.
DSouza AV, Elliott JT, Gunn JR, Barth RJ Jr, Samkoe KS, Tichauer KM, Pogue BW
Biomed Opt Express. 2015 Apr 1;6(4):1304-17. doi: 10.1364/BOE.6.001304. Epub 2015 Mar 17.
PMID: 25909014

A Pilot Study of Ultrasound-Guided Cryoablation of Invasive Ductal Carcinomas up to 15 mm With MRI Follow-Up and Subsequent Surgical Resection.
Poplack SP, Levine GM, Henry L, Wells WA, Heinemann FS, Hanna CM, Deneen DR, Tosteson TD, Barth RJ Jr
AJR Am J Roentgenol. 2015 May;204(5):1100-8. doi: 10.2214/AJR.13.12325.
PMID: 25905948

Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical assessment during breast conserving surgery.
McClatchy DM 3rd, Krishnaswamy V, Kanick SC, Elliott JT, Wells WA, Barth RJ Jr, Paulsen KD, Pogue BW
J Biomed Opt. 2015 Apr;20(4):040504. doi: 10.1117/1.JBO.20.4.040504.
PMID: 25901654

The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K, Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR, Miller TW
Breast Cancer Res Treat. 2015 Jan;149(1):69-79. doi: 10.1007/s10549-014-3201-6. Epub 2014 Dec 10.
PMID: 25491778

Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma.
Muller KE, Tafe LJ, de Abreu FB, Peterson JD, Wells WA, Barth RJ, Marotti JD
Hum Pathol. 2015 Feb;46(2):327-33. doi: 10.1016/j.humpath.2014.10.014. Epub 2014 Nov 4.
PMID: 25476122

Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.
Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW
Nat Med. 2014 Nov;20(11):1348-53. doi: 10.1038/nm.3732. Epub 2014 Oct 26.
PMID: 25344739

Structured light scatteroscopy.
Krishnaswamy V, Elliott JT, McClatchy DM 3rd, Barth RJ Jr, Wells WA, Pogue BW, Paulsen KD
J Biomed Opt. 2014;19(7):070504. doi: 10.1117/1.JBO.19.7.070504.
PMID: 25057960

The effect of neoadjuvant chemoradiation on pancreatic cancer-associated diabetes mellitus.
Gardner TB, Hessami N, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Zaki B, Tsapakos MJ, Suriawinata AA, Putra J, Tsongalis GJ, Mody K, Gordon SR, Pipas JM
Pancreas. 2014 Oct;43(7):1018-21. doi: 10.1097/MPA.0000000000000162.
PMID: 25000339