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Richard J. Barth, M.D.

Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Krishnaswamy V, Elliott JT, McClatchy DM 3rd, Barth RJ Jr, Wells WA, Pogue BW, Paulsen KD
Structured light scatteroscopy.
J Biomed Opt 2014 Jul; 19(7):070504
PMID: 25057960

Gardner TB, Hessami N, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Zaki B, Tsapakos MJ, Suriawinata AA, Putra J, Tsongalis GJ, Mody K, Gordon SR, Pipas JM
The effect of neoadjuvant chemoradiation on pancreatic cancer-associated diabetes mellitus.
Pancreas 2014 Oct; 43(7):1018-21
PMID: 25000339

Erkmen CP, Barth RJ Jr, Raman V
Case report: Successful treatment of recurrent chordoma and bilateral pulmonary metastases following an 11-year disease-free period.
Int J Surg Case Rep 2014; 5(7):424-7
PMID: 24907541

Liu X, Mody K, de Abreu FB, Pipas JM, Peterson JD, Gallagher TL, Suriawinata AA, Ripple GH, Hourdequin KC, Smith KD, Barth RJ Jr, Colacchio TA, Tsapakos MJ, Zaki BI, Gardner TB, Gordon SR, Amos CI, Wells WA, Tsongalis GJ
Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations.
Clin Chem 2014 Jul; 60(7):1004-11
PMID: 24821835

Pallone MJ, Poplack SP, Avutu HB, Paulsen KD, Barth RJ Jr
Supine breast MRI and 3D optical scanning: a novel approach to improve tumor localization for breast conserving surgery.
Ann Surg Oncol 2014 Jul; 21(7):2203-8
PMID: 24619494

Gardner TB, Glass LM, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Tsapakos MJ, Suriawinata AA, Tsongalis GJ, Pipas JM, Gordon SR
Pancreatic cyst prevalence and the risk of mucin-producing adenocarcinoma in US adults.
Am J Gastroenterol 2013 Oct; 108(10):1546-50
PMID: 24091499

Xue Y, Abou Tayoun AN, Abo KM, Pipas JM, Gordon SR, Gardner TB, Barth RJ Jr, Suriawinata AA, Tsongalis GJ
MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm.
Cancer Genet 2013 Jun; 206(6):217-21
PMID: 23933230

Rosenkranz KM, Tsui E, McCabe EB, Gui J, Underhill K, Barth RJ Jr
Increased rates of long-term complications after MammoSite brachytherapy compared with whole breast radiation therapy.
J Am Coll Surg 2013 Sep; 217(3):497-502
PMID: 23830216

Reeves JG, Suriawinata AA, Ng DP, Holubar SD, Mills JB, Barth RJ Jr
Short-term preoperative diet modification reduces steatosis and blood loss in patients undergoing liver resection.
Surgery 2013 Nov; 154(5):1031-7
PMID: 23809869

Laughney AM, Krishnaswamy V, Rice TB, Cuccia DJ, Barth RJ, Tromberg BJ, Paulsen KD, Pogue BW, Wells WA
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues.
J Biomed Opt 2013 Mar; 18(3):036012
PMID: 23525360