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Richard J. Barth, M.D.

Professor of Surgery


A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Norris Cotton Cancer Center

Curriculum Vitae:

NIH Biosketch:


Contact Information:

1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG

Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.

Selected Publications:


Hill MV, Holubar SD, Garfield Legare CI, Luurtsema CM, Barth RJ Jr
Perioperative Bundle Decreases Postoperative Hepatic Surgery Infections.
Ann Surg Oncol 2015 May 14;
PMID: 25971958

Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Proc Natl Acad Sci U S A 2015 May 26; 112(21):6682-7
PMID: 25964334

DSouza AV, Elliott JT, Gunn JR, Barth RJ Jr, Samkoe KS, Tichauer KM, Pogue BW
Nodal lymph flow quantified with afferent vessel input function allows differentiation between normal and cancer-bearing nodes.
Biomed Opt Express 2015 Apr 1; 6(4):1304-17
PMID: 25909014

Poplack SP, Levine GM, Henry L, Wells WA, Heinemann FS, Hanna CM, Deneen DR, Tosteson TD, Barth RJ Jr
A Pilot Study of Ultrasound-Guided Cryoablation of Invasive Ductal Carcinomas up to 15 mm With MRI Follow-Up and Subsequent Surgical Resection.
AJR Am J Roentgenol 2015 May; 204(5):1100-8
PMID: 25905948

McClatchy DM 3rd, Krishnaswamy V, Kanick SC, Elliott JT, Wells WA, Barth RJ Jr, Paulsen KD, Pogue BW
Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical assessment during breast conserving surgery.
J Biomed Opt 2015 Apr; 20(4):040504
PMID: 25901654

Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K, Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR, Miller TW
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
Breast Cancer Res Treat 2015 Jan; 149(1):69-79
PMID: 25491778

Muller KE, Tafe LJ, de Abreu FB, Peterson JD, Wells WA, Barth RJ, Marotti JD
Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma.
Hum Pathol 2015 Feb; 46(2):327-33
PMID: 25476122

Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW
Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.
Nat Med 2014 Nov; 20(11):1348-53
PMID: 25344739

Krishnaswamy V, Elliott JT, McClatchy DM 3rd, Barth RJ Jr, Wells WA, Pogue BW, Paulsen KD
Structured light scatteroscopy.
J Biomed Opt 2014; 19(7):070504
PMID: 25057960

Gardner TB, Hessami N, Smith KD, Ripple GH, Barth RJ, Klibansky DA, Colacchio TA, Zaki B, Tsapakos MJ, Suriawinata AA, Putra J, Tsongalis GJ, Mody K, Gordon SR, Pipas JM
The effect of neoadjuvant chemoradiation on pancreatic cancer-associated diabetes mellitus.
Pancreas 2014 Oct; 43(7):1018-21
PMID: 25000339