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Michael E. Zegans, M.D.

Title(s):
Professor of Surgery
Professor of

Department(s):
Surgery

Education:
F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

NIH Biosketch:
Zegans_M_BIO_2009-01-30.pdf

Websites:
http://www.dms.dartmouth.edu/microbio/faculty/

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Phone: 603-650-5123

Assistant: Megan Young
Asst. Phone: 603-650-5123

Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research: Ocular microbiology/infection and bacterial biofilm formation

Grant Information:

NEI: 5K08EY013977-05

5 year grant to study bacterial biofilm formation in eye infections involving pseudomonas aeruginosa

Steroids for Corneal Ulcer Trial (SCUT)

NEI funded trial of the role of topical steroids in the treatment of bacterial corneal ulceration. The study is a collaboration between the Proctor Foundation at UCSF, Dartmouth and Aravind Eye Hospital in Tamil Nadu, India.

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2012

Selected Publications:
 

Zegans ME, Wozniak D, Griffin E, Toutain-Kidd CM, Hammond JH, Garfoot A, Lam JS
Pseudomonas aeruginosa exopolysaccharide Psl promotes resistance to the biofilm inhibitor polysorbate 80.
Antimicrob Agents Chemother 2012 Aug; 56(8):4112-22
PMID: 22585230

O'Toole GA, Wathier M, Zegans ME, Shanks RM, Kowalski R, Grinstaff MW
Diphosphonium ionic liquids as broad-spectrum antimicrobial agents.
Cornea 2012 Jul; 31(7):810-6
PMID: 22236790

Ruoff KL, Toutain-Kidd CM, Srinivasan M, Lalitha P, Acharya NR, Zegans ME, Schwartzman JD
Corynebacterium macginleyi isolated from a corneal ulcer.
Infect Dis Rep 2010 Feb 17; 2(1)
PMID: 21709740

Zegans ME, Sanchez PA, Likosky DS, Allar RT, Martin M, Schwartzman JD, Pryor JH, Turco JH, Whitney CG
Clinical features, outcomes, and costs of a conjunctivitis outbreak caused by the ST448 strain of Streptococcus pneumoniae.
Cornea 2009 Jun; 28(5):503-9
PMID: 19421049

Toutain-Kidd CM, Kadivar SC, Bramante CT, Bobin SA, Zegans ME
Polysorbate 80 inhibition of Pseudomonas aeruginosa biofilm formation and its cleavage by the secreted lipase LipA.
Antimicrob Agents Chemother 2009 Jan; 53(1):136-45
PMID: 18955535

Zegans ME, Wagner JC, Cady KC, Murphy DM, Hammond JH, O'Toole GA
Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa.
J Bacteriol 2009 Jan; 191(1):210-9
PMID: 18952788

Kirn TJ, Levy NB, Gosselin JJ, Rosen WJ, Zegans ME
Peripheral T-cell lymphoma presenting as sclerouveitis.
Cornea 2007 Oct; 26(9):1147-9
PMID: 17893556

Bramante CT, Talbot EA, Rathinam SR, Stevens R, Zegans ME
Diagnosis of ocular tuberculosis: a role for new testing modalities?
Int Ophthalmol Clin 2007 Summer; 47(3):45-62
PMID: 17667275

Toutain CM, Caizza NC, Zegans ME, O'Toole GA
Roles for flagellar stators in biofilm formation by Pseudomonas aeruginosa.
Res Microbiol 2007 Jun; 158(5):471-7
PMID: 17533122

Zegans ME, Shanks RM, O'Toole GA
Bacterial biofilms and ocular infections.
Ocul Surf 2005 Apr; 3(2):73-80
PMID: 17131010