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Michael E. Zegans

Professor of Surgery
Professor of Microbiology and Immunology
Section Chief Ophthalmology

Microbiology and Immunology

F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

Molecular Pathogenesis Program


Contact Information:

Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-650-5123

Assistant: Elizabeth Arruda
Asst. Phone: 603-650-8746

Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research: Ocular microbiology/infection and bacterial biofilm formation

Grant Information:

NEI: 5K08EY013977-05

5 year grant to study bacterial biofilm formation in eye infections involving pseudomonas aeruginosa

Steroids for Corneal Ulcer Trial (SCUT)

NEI funded trial of the role of topical steroids in the treatment of bacterial corneal ulceration. The study is a collaboration between the Proctor Foundation at UCSF, Dartmouth and Aravind Eye Hospital in Tamil Nadu, India.

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2014

BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014

Selected Publications:


Association of Biofilm Formation, Psl Exopolysaccharide Expression, and Clinical Outcomes in Pseudomonas aeruginosa Keratitis: Analysis of Isolates in the Steroids for Corneal Ulcers Trial.
Zegans ME, DiGiandomenico A, Ray K, Naimie A, Keller AE, Stover CK, Lalitha P, Srinivasan M, Acharya NR, Lietman TM
JAMA Ophthalmol. 2016 Feb 4; doi: 10.1001/jamaophthalmol.2015.5956. Epub 2016 Feb 4.
PMID: 26846404

Acute effects of changes to the gravitational vector on the eye.
Anderson AP, Swan JG, Phillips SD, Knaus DA, Kattamis NT, Toutain-Kidd CM, Zegans ME, Fellows AM, Buckey JC
J Appl Physiol (1985). 2015 Dec 10;:jap.00730.2015. doi: 10.1152/japplphysiol.00730.2015. Epub 2015 Dec 10.
PMID: 26662052

Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.
Valentino MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C, Sanfilippo CM, Carter RA, Zegans ME, Beall B, Earl AM, Tuomanen EI, Morris TW, Haas W, Gilmore MS
Nat Commun. 2014 Nov 12;5:5411. doi: 10.1038/ncomms6411. Epub 2014 Nov 12.
PMID: 25388376

Considerations in understanding the ocular surface microbiome.
Zegans ME, Van Gelder RN
Am J Ophthalmol. 2014 Sep;158(3):420-2. doi: 10.1016/j.ajo.2014.06.014.
PMID: 25132249

Early addition of topical corticosteroids in the treatment of bacterial keratitis.
Ray KJ, Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Glidden DV, Oldenburg CE, Sun CQ, Zegans ME, McLeod SD, Acharya NR, Lietman TM
JAMA Ophthalmol. 2014 Jun;132(6):737-41. doi: 10.1001/jamaophthalmol.2014.292.
PMID: 24763755

Visual recovery in treated bacterial keratitis.
Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, Ray KJ, Zegans ME, Acharya NR, Lietman TM, Keenan JD, Steroids for Corneal Ulcers Trial Group
Ophthalmology. 2014 Jun;121(6):1310-1. doi: 10.1016/j.ophtha.2013.12.041. Epub 2014 Mar 5.
PMID: 24612976

Evaluation of fungal keratitis using a newly developed computer program, Optscore, for grading digital corneal photographs.
Toutain-Kidd CM, Porco TC, Kidd EM, Srinivasan M, Prajna NV, Acharya N, Lietman T, Zegans ME
Ophthalmic Epidemiol. 2014 Feb;21(1):24-32. doi: 10.3109/09286586.2013.868003.
PMID: 24467559

The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.
Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, O'Brien KS, Glidden DV, Ray KJ, Oldenburg CE, Zegans ME, Whitcher JP, McLeod SD, Porco TC, Lietman TM, Acharya NR, Steroids for Corneal Ulcers Trial Group
Am J Ophthalmol. 2014 Feb;157(2):327-333.e3. doi: 10.1016/j.ajo.2013.09.025. Epub 2013 Oct 1.
PMID: 24315294

Pseudomonas aeruginosa exopolysaccharide Psl promotes resistance to the biofilm inhibitor polysorbate 80.
Zegans ME, Wozniak D, Griffin E, Toutain-Kidd CM, Hammond JH, Garfoot A, Lam JS
Antimicrob Agents Chemother. 2012 Aug;56(8):4112-22. doi: 10.1128/AAC.00373-12. Epub 2012 May 14.
PMID: 22585230

Diphosphonium ionic liquids as broad-spectrum antimicrobial agents.
O'Toole GA, Wathier M, Zegans ME, Shanks RM, Kowalski R, Grinstaff MW
Cornea. 2012 Jul;31(7):810-6. doi: 10.1097/ICO.0b013e31823f0a86.
PMID: 22236790