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Michael E. Zegans, MD

Professor of Surgery
Professor of Microbiology and Immunology
Section Chief Ophthalmology

Microbiology and Immunology

F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

Molecular Pathogenesis Program


Contact Information:

Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-650-5123

Asst. Phone: 603-650-8746

Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research: Ocular microbiology/infection and bacterial biofilm formation

Grant Information:

NEI: 5K08EY013977-05

5 year grant to study bacterial biofilm formation in eye infections involving pseudomonas aeruginosa

Steroids for Corneal Ulcer Trial (SCUT)

NEI funded trial of the role of topical steroids in the treatment of bacterial corneal ulceration. The study is a collaboration between the Proctor Foundation at UCSF, Dartmouth and Aravind Eye Hospital in Tamil Nadu, India.

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-present

BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2016

Selected Publications:


The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR
Cornea. 2017 Mar;36(3):358-362. doi: 10.1097/ICO.0000000000001132.
PMID: 28079684

Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial.
Prajna NV, Krishnan T, Rajaraman R, Patel S, Srinivasan M, Das M, Ray KJ, O'Brien KS, Oldenburg CE, McLeod SD, Zegans ME, Porco TC, Acharya NR, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial II Group.
JAMA Ophthalmol. 2016 Dec 1;134(12):1365-1372. doi: 10.1001/jamaophthalmol.2016.4096.
PMID: 27787540

Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates.
Fuller KK, Cramer RA, Zegans ME, Dunlap JC, Loros JJ
MBio. 2016 Sep 20;7(5) pii: e01517-16. doi: 10.1128/mBio.01517-16. Epub 2016 Sep 20.
PMID: 27651362

Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers.
Hammond JH, Hebert WP, Naimie A, Ray K, Van Gelder RD, DiGiandomenico A, Lalitha P, Srinivasan M, Acharya NR, Lietman T, Hogan DA, Zegans ME
mSphere. 2016 Sep 7;1(5) pii: e00140-16. doi: 10.1128/mSphere.00140-16. Epub 2016 Sep 7.
PMID: 27631025

Bacterial corneal ulcer associated with common variable immune deficiency.
Tsui E, Deng J, Siedlecki AN, Zegans ME
J Ophthalmic Inflamm Infect. 2016 Dec;6(1):28. doi: 10.1186/s12348-016-0098-8. Epub 2016 Aug 5.
PMID: 27491761

Changing Azole Resistance: A Secondary Analysis of the MUTT I Randomized Clinical Trial.
Prajna NV, Lalitha P, Rajaraman R, Krishnan T, Raghavan A, Srinivasan M, O'Brien KS, Zegans M, McLeod SD, Acharya NR, Keenan JD, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial Group.
JAMA Ophthalmol. 2016 Jun 1;134(6):693-6. doi: 10.1001/jamaophthalmol.2016.0530.
PMID: 27054515

Candida Interface Infections After Descemet Stripping Automated Endothelial Keratoplasty.
Tsui E, Fogel E, Hansen K, Talbot EA, Tammer R, Fogel J, Daly ER, Noble J, Caine L, Zegans ME
Cornea. 2016 Apr;35(4):456-64. doi: 10.1097/ICO.0000000000000778.
PMID: 26890665

Surgery Versus Interferon Alpha-2b Treatment Strategies for Ocular Surface Squamous Neoplasia: A Literature-Based Decision Analysis.
Siedlecki AN, Tapp S, Tosteson AN, Larson RJ, Karp CL, Lietman T, Zegans ME
Cornea. 2016 May;35(5):613-8. doi: 10.1097/ICO.0000000000000766.
PMID: 26890663

Association of Biofilm Formation, Psl Exopolysaccharide Expression, and Clinical Outcomes in Pseudomonas aeruginosa Keratitis: Analysis of Isolates in the Steroids for Corneal Ulcers Trial.
Zegans ME, DiGiandomenico A, Ray K, Naimie A, Keller AE, Stover CK, Lalitha P, Srinivasan M, Acharya NR, Lietman TM
JAMA Ophthalmol. 2016 Apr;134(4):383-9. doi: 10.1001/jamaophthalmol.2015.5956.
PMID: 26846404

Acute effects of changes to the gravitational vector on the eye.
Anderson AP, Swan JG, Phillips SD, Knaus DA, Kattamis NT, Toutain-Kidd CM, Zegans ME, Fellows AM, Buckey JC
J Appl Physiol (1985). 2016 Apr 15;120(8):939-46. doi: 10.1152/japplphysiol.00730.2015. Epub 2015 Dec 10.
PMID: 26662052