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Michael E. Zegans, M.D.

Professor of Surgery
Professor of Microbiology and Immunology
Section Chief Ophthalmology

Microbiology and Immunology

F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

Molecular Pathogenesis Program

NIH Biosketch:


Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Phone: 603-650-5123

Assistant: Elizabeth Arruda
Asst. Phone: 603-650-5123

Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research: Ocular microbiology/infection and bacterial biofilm formation

Grant Information:

NEI: 5K08EY013977-05

5 year grant to study bacterial biofilm formation in eye infections involving pseudomonas aeruginosa

Steroids for Corneal Ulcer Trial (SCUT)

NEI funded trial of the role of topical steroids in the treatment of bacterial corneal ulceration. The study is a collaboration between the Proctor Foundation at UCSF, Dartmouth and Aravind Eye Hospital in Tamil Nadu, India.

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2014

BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014

Selected Publications:


Valentino MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C, Sanfilippo CM, Carter RA, Zegans ME, Beall B, Earl AM, Tuomanen EI, Morris TW, Haas W, Gilmore MS
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.
Nat Commun 2014 Nov 12; 5:5411
PMID: 25388376

Zegans ME, Van Gelder RN
Considerations in understanding the ocular surface microbiome.
Am J Ophthalmol 2014 Sep; 158(3):420-2
PMID: 25132249

Ray KJ, Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Glidden DV, Oldenburg CE, Sun CQ, Zegans ME, McLeod SD, Acharya NR, Lietman TM
Early addition of topical corticosteroids in the treatment of bacterial keratitis.
JAMA Ophthalmol 2014 Jun; 132(6):737-41
PMID: 24763755

Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, Ray KJ, Zegans ME, Acharya NR, Lietman TM, Keenan JD
Visual recovery in treated bacterial keratitis.
Ophthalmology 2014 Jun; 121(6):1310-1
PMID: 24612976

Toutain-Kidd CM, Porco TC, Kidd EM, Srinivasan M, Prajna NV, Acharya N, Lietman T, Zegans ME
Evaluation of fungal keratitis using a newly developed computer program, Optscore, for grading digital corneal photographs.
Ophthalmic Epidemiol 2014 Feb; 21(1):24-32
PMID: 24467559

Srinivasan M, Mascarenhas J, Rajaraman R, Ravindran M, Lalitha P, O'Brien KS, Glidden DV, Ray KJ, Oldenburg CE, Zegans ME, Whitcher JP, McLeod SD, Porco TC, Lietman TM, Acharya NR
The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.
Am J Ophthalmol 2014 Feb; 157(2):327-333.e3
PMID: 24315294

Zegans ME, Wozniak D, Griffin E, Toutain-Kidd CM, Hammond JH, Garfoot A, Lam JS
Pseudomonas aeruginosa exopolysaccharide Psl promotes resistance to the biofilm inhibitor polysorbate 80.
Antimicrob Agents Chemother 2012 Aug; 56(8):4112-22
PMID: 22585230

O'Toole GA, Wathier M, Zegans ME, Shanks RM, Kowalski R, Grinstaff MW
Diphosphonium ionic liquids as broad-spectrum antimicrobial agents.
Cornea 2012 Jul; 31(7):810-6
PMID: 22236790

Ruoff KL, Toutain-Kidd CM, Srinivasan M, Lalitha P, Acharya NR, Zegans ME, Schwartzman JD
Corynebacterium macginleyi isolated from a corneal ulcer.
Infect Dis Rep 2010 Feb 17; 2(1)
PMID: 21709740

Zegans ME, Sanchez PA, Likosky DS, Allar RT, Martin M, Schwartzman JD, Pryor JH, Turco JH, Whitney CG
Clinical features, outcomes, and costs of a conjunctivitis outbreak caused by the ST448 strain of Streptococcus pneumoniae.
Cornea 2009 Jun; 28(5):503-9
PMID: 19421049