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Bruce A. Stanton, PhD

Title(s):
Professor of Microbiology and Immunology
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences

Department(s):
Microbiology and Immunology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 615 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

R01-HL074175 08/15/03 - 06/30/19
NIH/NHLBI
Title: Role of Virulence Factors in Pseudomonas-Host Interactions
Specific aims of project: The major goal of this project is to elucidate how outer membrane vesicles secreted by P. aeruginosa inhibit CFTR Cl secretion by airway epithelial cells.
Role: PI


P42-ES007373 4/01/14 - 03/31/19
NIH/NIEHS
Title: Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
PI Project #3: Arsenic and Innate Immunity in Human Lung
Specific aims of project: The major goal of this project is to test the hypothesis that arsenite, MMA and DMA have differential, dose dependent adverse effects on P. aeruginosa infections of the lung by modulating the innate immune response.
Role: PI


P30-GM106394 09/01/13 - 7/31/18
NIH/NIGMS
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Specific aims of project: The major goal of this grant is to provide Core support and pilot project funding to members of the Lung Biology Center.
Role: PI


STANTO19R0 7/01/15 - 6/30/19
CF Foundation
Title: CF Research Development Program (RDP)
Specific aims of project: The major goal of this grant is to facilitate research to identify novel drugable targets and to develop new therapies for CF patients. This grant supports core facilities and pilot project grants. As PI, Dr. Stanton is not eligible for pilot grant support.
Role: PI

P20-GM103534 09/01/11 - 07/31/16
NIH/NIGMS
Title: Quantitative Biology Research Institute
Specific aims of project: The goal of this program is to establish a Quantitative Biology Research Institute that will enhance the ability of scientists to use mathematics and computer science to solve complex biomedical research questions.
Role: Co-I on Administrative Core

Cystic Fibrosis Foundation: Research Grant 04/01/16 - 03/31/18
Title: Effects of VX-809 and VX-770 on Macrophage Function and Inflammation
Specific aims of project: To elucidate the ability of VX-809 and VX-770 to enhance the ability of macrophages to phagocytose and kill P. aeruginosa.
Role: PI

Sanofi: Research Grant 04/01/16 - 03/31/17
Title: Effects of novel iron chelators on Pseudomonas aeruginosa biofilm formation
Specific aims of project: To test the ability of a novel Sanofi drug to kill P. aeruginosa.
Role: PI

Courses Taught:

Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th editionĚ, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.


Selected Publications:

 

Effects of <i>Pseudomonas aeruginosa</i> on CFTR chloride secretion and the host immune response.
Stanton BA
Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C357-C366. doi: 10.1152/ajpcell.00373.2016. Epub 2017 Jan 25.
PMID: 28122735

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.
Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA
PLoS Pathog. 2016 Jun;12(6):e1005672. doi: 10.1371/journal.ppat.1005672. Epub 2016 Jun 13.
PMID: 27295279

Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease.
Hogan DA, Willger SD, Dolben EL, Hampton TH, Stanton BA, Morrison HG, Sogin ML, Czum J, Ashare A
PLoS One. 2016;11(3):e0149998. doi: 10.1371/journal.pone.0149998. Epub 2016 Mar 4.
PMID: 26943329

COMPUTATIONAL APPROACHES TO STUDY MICROBES AND MICROBIOMES.
Greene CS, Foster JA, Stanton BA, Hogan DA, Bromberg Y
Pac Symp Biocomput. 2016;21:557-67.
PMID: 26776218

Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa.
Notch EG, Goodale BC, Barnaby R, Coutermarsh B, Berwin B, Taylor VF, Jackson BP, Stanton BA
PLoS One. 2015;10(11):e0142392. doi: 10.1371/journal.pone.0142392. Epub 2015 Nov 10.
PMID: 26554712

MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic.
Stanton BA, Caldwell K, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Mayer G, Miller D, Navas-Acien A, Nordstrom DK, Postema S, Rardin L, Rosen B, SenGupta A, Shaw J, Stanton E, Susca P
Curr Environ Health Rep. 2015 Sep;2(3):329-37. doi: 10.1007/s40572-015-0057-9.
PMID: 26231509

Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR
Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9881-5. doi: 10.1002/anie.201503983. Epub 2015 Jul 1.
PMID: 26136396

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Stanton BA, Coutermarsh B, Barnaby R, Hogan D
PLoS One. 2015;10(5):e0127742. doi: 10.1371/journal.pone.0127742. Epub 2015 May 27.
PMID: 26018799

Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes.
Heussler GE, Cady KC, Koeppen K, Bhuju S, Stanton BA, O'Toole GA
MBio. 2015 May 12;6(3):e00129-15. doi: 10.1128/mBio.00129-15. Epub 2015 May 12.
PMID: 25968642

A novel variant of aquaporin 3 is expressed in killifish (Fundulus heteroclitus) intestine.
Jung D, Adamo MA, Lehman RM, Barnaby R, Jackson CE, Jackson BP, Shaw JR, Stanton BA
Comp Biochem Physiol C Toxicol Pharmacol. 2015 May;171:1-7. doi: 10.1016/j.cbpc.2015.03.001. Epub 2015 Mar 9.
PMID: 25766383