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Bruce A. Stanton, PhD

Title(s):
Professor of Microbiology and Immunology
Professor of Physiology and Neurobiology
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences

Department(s):
Microbiology and Immunology
Physiology and Neurobiology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 615 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu

Assistant: none


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

National Institutes of Health - NCRR (P20-RR018787/GM103413)
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Principal Investigator: B.A. Stanton
Project Period: 10/01/03 - 6/30/18

NIH-NIEHS (P42 ES007373-18)
Title: Toxic Metals in The Northeast
Principal Investigator: B.A. Stanton
Project Period: 4/01/13 - 3/31/19

Cystic Fibrosis Foundation: Research Development Program
Title: CF Research Development Program (STANTO11R0)
Principal Investigator: B.A. Stanton
Project Period: 7/1/07 - 6/30/15

Cystic Fibrosis Foundation: Research Grant
Title: P. aeruginosa Outer Membrane Vesicles as a Therapeutic Target
Principal Investigator: B.A. Stanton
Project Period: 04/01/14 - 03/31/15

National Institutes of Health (R01 HL074175)
Title: P. aeruginosa pathogenicity: TAP and Class I MHC Trafficking
Principal Investigator: B.A. Stanton
Project Period: 4/1/05 - 3/31/15

National Institutes of Health (T32-DK-07301-34)
Title: Epithelial Biology Training Grant
Principal Investigator: B.A. Stanton
7/1/05 - 6/30/15

Courses Taught:

Molecular Mechanisms of Human Disease-Geisel School of Medicine
Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th editionĚ, and Physiology, now in its 6th edition. He was named Andrew C. Vail Professor in 2010.


Selected Publications:

 

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.
Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA
PLoS Pathog. 2016 Jun;12(6):e1005672. doi: 10.1371/journal.ppat.1005672. Epub 2016 Jun 13.
PMID: 27295279

Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease.
Hogan DA, Willger SD, Dolben EL, Hampton TH, Stanton BA, Morrison HG, Sogin ML, Czum J, Ashare A
PLoS One. 2016;11(3):e0149998. doi: 10.1371/journal.pone.0149998. Epub 2016 Mar 4.
PMID: 26943329

COMPUTATIONAL APPROACHES TO STUDY MICROBES AND MICROBIOMES.
Greene CS, Foster JA, Stanton BA, Hogan DA, Bromberg Y
Pac Symp Biocomput. 2016;21:557-67.
PMID: 26776218

Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa.
Notch EG, Goodale BC, Barnaby R, Coutermarsh B, Berwin B, Taylor VF, Jackson BP, Stanton BA
PLoS One. 2015;10(11):e0142392. doi: 10.1371/journal.pone.0142392. Epub 2015 Nov 10.
PMID: 26554712

MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic.
Stanton BA, Caldwell K, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Mayer G, Miller D, Navas-Acien A, Nordstrom DK, Postema S, Rardin L, Rosen B, SenGupta A, Shaw J, Stanton E, Susca P
Curr Environ Health Rep. 2015 Sep;2(3):329-37. doi: 10.1007/s40572-015-0057-9.
PMID: 26231509

Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR
Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9881-5. doi: 10.1002/anie.201503983. Epub 2015 Jul 1.
PMID: 26136396

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Stanton BA, Coutermarsh B, Barnaby R, Hogan D
PLoS One. 2015;10(5):e0127742. doi: 10.1371/journal.pone.0127742. Epub 2015 May 27.
PMID: 26018799

Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes.
Heussler GE, Cady KC, Koeppen K, Bhuju S, Stanton BA, O'Toole GA
MBio. 2015 May 12;6(3):e00129-15. doi: 10.1128/mBio.00129-15. Epub 2015 May 12.
PMID: 25968642

A novel variant of aquaporin 3 is expressed in killifish (Fundulus heteroclitus) intestine.
Jung D, Adamo MA, Lehman RM, Barnaby R, Jackson CE, Jackson BP, Shaw JR, Stanton BA
Comp Biochem Physiol C Toxicol Pharmacol. 2015 May;171:1-7. doi: 10.1016/j.cbpc.2015.03.001. Epub 2015 Mar 9.
PMID: 25766383

Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.
McShane AJ, Bajrami B, Ramos AA, Diego-Limpin PA, Farrokhi V, Coutermarsh BA, Stanton BA, Jensen T, Riordan JR, Wetmore D, Joseloff E, Yao X
J Proteome Res. 2014 Nov 7;13(11):4676-85. doi: 10.1021/pr5006795. Epub 2014 Oct 3.
PMID: 25227318