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Bruce A. Stanton, Ph.D.

Title(s):
Professor of Microbiology and Immunology
Professor of Physiology and Neurobiology
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences

Department(s):
Microbiology and Immunology
Physiology and Neurobiology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 615 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu

Assistant: none


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

National Institutes of Health - NCRR (P20-RR018787/GM103413)
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Principal Investigator: B.A. Stanton
Project Period: 10/01/03 - 6/30/18

NIH-NIEHS (P42 ES007373-18)
Title: Toxic Metals in The Northeast
Principal Investigator: B.A. Stanton
Project Period: 4/01/13 - 3/31/19

Cystic Fibrosis Foundation: Research Development Program
Title: CF Research Development Program (STANTO11R0)
Principal Investigator: B.A. Stanton
Project Period: 7/1/07 - 6/30/15

Cystic Fibrosis Foundation: Research Grant
Title: P. aeruginosa Outer Membrane Vesicles as a Therapeutic Target
Principal Investigator: B.A. Stanton
Project Period: 04/01/14 - 03/31/15

National Institutes of Health (R01 HL074175)
Title: P. aeruginosa pathogenicity: TAP and Class I MHC Trafficking
Principal Investigator: B.A. Stanton
Project Period: 4/1/05 - 3/31/15

National Institutes of Health (T32-DK-07301-34)
Title: Epithelial Biology Training Grant
Principal Investigator: B.A. Stanton
7/1/05 - 6/30/15

Courses Taught:

Molecular Mechanisms of Human Disease-Geisel School of Medicine
Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th editionĚ, and Physiology, now in its 6th edition. He was named Andrew C. Vail Professor in 2010.


Selected Publications:

 

Moreau-Marquis S, Coutermarsh B, Stanton BA
Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells.
J Antimicrob Chemother 2014 Sep 11;
PMID: 25213272

Shaw JR, Hampton TH, King BL, Whitehead A, Galvez F, Gross RH, Keith N, Notch E, Jung D, Glaholt SP, Chen CY, Colbourne JK, Stanton BA
Natural Selection Canalizes Expression Variation of Environmentally Induced Plasticity-Enabling Genes.
Mol Biol Evol 2014 Aug 25;
PMID: 25158801

Ballok AE, Filkins LM, Bomberger JM, Stanton BA, O'Toole GA
Epoxide-mediated differential packaging of cif and other virulence factors into outer membrane vesicles.
J Bacteriol 2014 Oct 15; 196(20):3633-42
PMID: 25112474

Hampton TH, Green DM, Cutting GR, Morrison HG, Sogin ML, Gifford AH, Stanton BA, O'Toole GA
The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention.
Microbiome 2014; 2:14
PMID: 25071935

Koeppen K, Coutermarsh BA, Madden DR, Stanton BA
Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.
J Biol Chem 2014 Jun 13; 289(24):17142-50
PMID: 24811177

Bomberger JM, Coutermarsh BA, Barnaby RL, Sato JD, Chapline MC, Stanton BA
Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval.
PLoS One 2014; 9(2):e89599
PMID: 24586903

Gifford AH, Alexandru DM, Li Z, Dorman DB, Moulton LA, Price KE, Hampton TH, Sogin ML, Zuckerman JB, Parker HW, Stanton BA, O'Toole GA
Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis.
J Cyst Fibros 2014 May; 13(3):311-8
PMID: 24332997

Bomberger JM, Ely KH, Bangia N, Ye S, Green KA, Green WR, Enelow RI, Stanton BA
Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation.
J Biol Chem 2014 Jan 3; 289(1):152-62
PMID: 24247241

Jackson AA, Gross MJ, Daniels EF, Hampton TH, Hammond JH, Vallet-Gely I, Dove SL, Stanton BA, Hogan DA
Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.
J Bacteriol 2013 Jul; 195(13):3093-104
PMID: 23667230

Zhou Y, Song K, Painter RG, Aiken M, Reiser J, Stanton BA, Nauseef WM, Wang G
Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils.
J Innate Immun 2013; 5(3):219-30
PMID: 23486169