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Bruce A. Stanton, Ph.D.

Title(s):
Professor of Microbiology and Immunology
Professor of Physiology and Neurobiology
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences

Department(s):
Microbiology and Immunology
Physiology and Neurobiology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 615 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu

Assistant: none


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

National Institutes of Health - NCRR (P20-RR018787/GM103413)
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Principal Investigator: B.A. Stanton
Project Period: 10/01/03 - 6/30/18

NIH-NIEHS (P42 ES007373-18)
Title: Toxic Metals in The Northeast
Principal Investigator: B.A. Stanton
Project Period: 4/01/13 - 3/31/19

Cystic Fibrosis Foundation: Research Development Program
Title: CF Research Development Program (STANTO11R0)
Principal Investigator: B.A. Stanton
Project Period: 7/1/07 - 6/30/15

Cystic Fibrosis Foundation: Research Grant
Title: P. aeruginosa Outer Membrane Vesicles as a Therapeutic Target
Principal Investigator: B.A. Stanton
Project Period: 04/01/14 - 03/31/15

National Institutes of Health (R01 HL074175)
Title: P. aeruginosa pathogenicity: TAP and Class I MHC Trafficking
Principal Investigator: B.A. Stanton
Project Period: 4/1/05 - 3/31/15

National Institutes of Health (T32-DK-07301-34)
Title: Epithelial Biology Training Grant
Principal Investigator: B.A. Stanton
7/1/05 - 6/30/15

Courses Taught:

Molecular Mechanisms of Human Disease-Geisel School of Medicine
Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th editionĚ, and Physiology, now in its 6th edition. He was named Andrew C. Vail Professor in 2010.


Selected Publications:

 

Stanton BA, Caldwell K, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Mayer G, Miller D, Navas-Acien A, Nordstrom DK, Postema S, Rardin L, Rosen B, SenGupta A, Shaw J, Stanton E, Susca P
MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic.
Curr Environ Health Rep 2015 Sep; 2(3):329-37
PMID: 26231509

Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR
Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.
Angew Chem Int Ed Engl 2015 Aug 17; 54(34):9881-5
PMID: 26136396

Stanton BA, Coutermarsh B, Barnaby R, Hogan D
Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
PLoS One 2015; 10(5):e0127742
PMID: 26018799

Heussler GE, Cady KC, Koeppen K, Bhuju S, Stanton BA, O'Toole GA
Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes.
MBio 2015 May 12; 6(3):e00129-15
PMID: 25968642

Jung D, Adamo MA, Lehman RM, Barnaby R, Jackson CE, Jackson BP, Shaw JR, Stanton BA
A novel variant of aquaporin 3 is expressed in killifish (Fundulus heteroclitus) intestine.
Comp Biochem Physiol C Toxicol Pharmacol 2015 May; 171:1-7
PMID: 25766383

McShane AJ, Bajrami B, Ramos AA, Diego-Limpin PA, Farrokhi V, Coutermarsh BA, Stanton BA, Jensen T, Riordan JR, Wetmore D, Joseloff E, Yao X
Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.
J Proteome Res 2014 Nov 7; 13(11):4676-85
PMID: 25227318

Moreau-Marquis S, Coutermarsh B, Stanton BA
Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells.
J Antimicrob Chemother 2015 Jan; 70(1):160-6
PMID: 25213272

Shaw JR, Hampton TH, King BL, Whitehead A, Galvez F, Gross RH, Keith N, Notch E, Jung D, Glaholt SP, Chen CY, Colbourne JK, Stanton BA
Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes.
Mol Biol Evol 2014 Nov; 31(11):3002-15
PMID: 25158801

Ballok AE, Filkins LM, Bomberger JM, Stanton BA, O'Toole GA
Epoxide-mediated differential packaging of Cif and other virulence factors into outer membrane vesicles.
J Bacteriol 2014 Oct; 196(20):3633-42
PMID: 25112474

Hampton TH, Green DM, Cutting GR, Morrison HG, Sogin ML, Gifford AH, Stanton BA, O'Toole GA
The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention.
Microbiome 2014; 2:14
PMID: 25071935