Bruce A. Stanton, Ph.D.
Professor of Microbiology and Immunology
Professor of Physiology
Microbiology and Immunology
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine
Geisel School of Medicine
Hanover NH 03755
Office: 615 Remsen
There are four major projects in the laboratory:
1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.
3. CF drug discovery. In collaboration with several biotechnology companies our laboratory is developing new therapeutic approaches to treat and cure CF.
4. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa .
Rotations and Thesis Projects:
1. Host-pathogen interactions in Cystic Fibrosis.
2. Arsenic and innate immunity
National Institutes of Health - NCRR (P20-RR01878-07). Cellular and Molecular Mechanisms of Lung Disease COBRE¯.
NIH-NIEHS (P42 ES007373-15). Toxic Metals in The Northeast¯.
Cystic Fibrosis Foundation (STANTO0710-02). P. aeruginosa biofilm formation on polarized CF epithelial cells.
Cystic Fibrosis Foundation. Research Development Program.
National Institutes of Health (R01 HL074175-07).P. aeruginosa pathogenicity: TAP and Class I MHC Trafficking¯.
NIEHS: R25 (ES016254). STEER program at the Mount Desert Island Biological Laboratory (MDIBL): Pathways of Chemical Action in Human Disease¯.
National Institutes of Health (T32-DK-07301-32).Epithelial Biology Training Grant¯.
PEMM 101/102 - Scientific Basis of Disease
Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th edition¯, and Physiology, now in its 6th edition. He was named Andrew C. Vail Memorial Professor in 2010.
Ye S, Cihil K, Stolz DB, Pilewski JM, Stanton BA, Swiatecka-Urban A. c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem. 2010 Aug 27;285(35):27008-18. (view details on MedLine)
Gifford AH, Miller SD, Jackson BP, Hampton TH, O'Toole GA, Stanton BA, Parker HW. Iron and CF-related anemia: expanding clinical and biochemical relationships. Pediatr Pulmonol. 2011 Feb;46(2):160-5. doi: 10.1002/ppul.21335. (view details on MedLine)
Moreau-Marquis S, Redelman CV, Stanton BA, Anderson GG. Co-culture models of Pseudomonas aeruginosa biofilms grown on live human airway cells. J Vis Exp. 2010 Oct 6;(44). pii: 2186. doi: 10.3791/2186. (view details on MedLine)
Bomberger JM, Ye S, Maceachran DP, Koeppen K, Barnaby RL, O'Toole GA, Stanton BA. A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system. PLoS Pathog. 2011 Mar;7(3):e1001325. (view details on MedLine)
Bomberger JM, Guggino WB, Stanton BA. Methods to monitor cell surface expression and endocytic trafficking of CFTR in polarized epithelial cells. Methods Mol Biol. 2011;741:271-83. (view details on MedLine)
Jung D, Sato JD, Shaw JR, Stanton BA. Expression of aquaporin 3 in gills of the Atlantic killifish (Fundulus heteroclitus): Effects of seawater acclimation. Comp Biochem Physiol A Mol Integr Physiol. 2012 Mar;161(3):320-6. (view details on MedLine)
Notch EG, Shaw JR, Coutermarsh BA, Dzioba M, Stanton BA. Morpholino gene knockdown in adult Fundulus heteroclitus: role of SGK1 in seawater acclimation. PLoS One. 2011;6(12):e29462. (view details on MedLine)
Jung D, MacIver B, Jackson BP, Barnaby R, Sato JD, Zeidel ML, Shaw JR, Stanton BA. A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel. Toxicol Sci. 2012 May;127(1):101-9. (view details on MedLine)
Bomberger JM, Coutermarsh BA, Barnaby RL, Stanton BA. Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells. J Biol Chem. 2012 May 18;287(21):17130-9. (view details on MedLine)
Notch EG, Chapline C, Flynn E, Lameyer T, Lowell A, Sato D, Shaw JR, Stanton BA. Mitogen activated protein kinase 14-1 regulates serum glucocorticoid kinase 1 during seawater acclimation in Atlantic killifish, Fundulus heteroclitus. Comp Biochem Physiol A Mol Integr Physiol. 2012 Aug;162(4):443-8 (view details on MedLine)