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Jacqueline Y. Channon Smith, Ph.D.

Assistant Professor of Microbiology and Immunology
DartLab Director

Microbiology and Immunology

U. London, PhD 1984
U. Auckland, BS 1972

Dr. Smith received her B.Sc. from the University of Auckland in 1972, and her Ph.D. from the University of London in 1984. After postdoctoral work as an NIH research fellow and research associate in the Department of Pediatrics at the National Jewish Center for Immunology and Respiratory Disease and the Department of Microbiology at Dartmouth Medical School, Dr. Smith joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1994.

Norris Cotton Cancer Center


Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7937
1 Medical Center Dr
Lebanon NH 03756

Phone: 603-653-9916
Fax: 603-653-9900
Email: jacqueline.smith@dartmouth.edu

Assistant: Alan Bergeron
Asst. Phone: 603-653-9914
Asst. Email: ajb@dartmouth.edu

Professional Interests:

Jacqueline Y. Channon Smith, Ph.D.
Assistant Professor of Microbiology & Immunology

The Immune Monitoring Laboratory provides blood isolation services, runs high complexity immunoassays, and carries out R&D to develop cutting edge assays. All work complies with Good Laboratory Practices standards and includes rigorous Quality Assurance and Quality Control.

My current research interest lies in understanding the immunology of Alzheimer's disease and developing a blood marker for the disease precursor, mild cognitive impairment. These studies are part of a broader investigation on a cohort of elderly people with early Alzheimer's disease, pre-Alzheimer's disease (mild cognitive impairment and cognitive complaints) and healthy controls, who are enrolled in an ongoing longitudinal neuroimaging, cognition and neurogenetics study. This work is in collaboration with Dr Andrew Saykin.

Courses Taught:

Flow Cytometry

Selected Publications:


The natural killer-activating receptor, NKG2D, on CD3+CD8+ T cells plays a critical role in identifying and killing autologous myeloma cells.
Talebian L, Fischer DA, Wu J, Channon JY, Sentman CL, Ernstoff MS, Meehan KR
Transfusion. 2014 Jun;54(6):1515-21. doi: 10.1111/trf.12517. Epub 2014 Jan 22.
PMID: 24446786

A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: tumor-specific immune responses are associated with improved survival.
Barth RJ Jr, Fisher DA, Wallace PK, Channon JY, Noelle RJ, Gui J, Ernstoff MS
Clin Cancer Res. 2010 Nov 15;16(22):5548-56. doi: 10.1158/1078-0432.CCR-10-2138. Epub 2010 Sep 30.
PMID: 20884622

Corr4A and VRT325 do not reduce the inflammatory response to P. aeruginosa in human cystic fibrosis airway epithelial cells.
Talebian L, Coutermarsh B, Channon JY, Stanton BA
Cell Physiol Biochem. 2009;23(1-3):199-204. doi: 10.1159/000204108. Epub 2009 Feb 18.
PMID: 19255514

The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells).
Armand R, Channon JY, Kintner J, White KA, Miselis KA, Perez RP, Lewis LD
Toxicol Appl Pharmacol. 2004 Apr 1;196(1):68-79.
PMID: 15050409

Toxoplasma gondii induces granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor secretion by human fibroblasts: implications for neutrophil apoptosis.
Channon JY, Miselis KA, Minns LA, Dutta C, Kasper LH
Infect Immun. 2002 Nov;70(11):6048-57.
PMID: 12379681