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Lloyd H. Kasper, M.D.

Title(s):
Professor of Medicine
Professor of Microbiology and Immunology

Department(s):
Medicine
Microbiology and Immunology

Education:
Rush Medical College, MD 1975
University of Illinois, MS 1973
University of Illinois, BS 1970
University of Illinois, BA 1970
Dartmouth College MA (honorary) 1994

Lloyd Kasper received his undergraduate degrees in Rhetoric and Zoology from the University of Illinois, Urbana. After completing medical school in Chicago, he received clinical training in Internal Medicine and Neurology. He was appointed to the Dartmouth Medical School faculty in 1981. In addition to his research responsibilities, he is the Director of the Dartmouth-Hitchcock Multiple Sclerosis Clinic.

Programs:
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/ncd/

Contact Information:

Dartmouth Medical School
Rubin Bldg 701 HB 7556
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9909
Fax: 603-653-9947
Email: Lloyd.H.Kasper@Dartmouth.EDU

Assistant: mary r. smith
Asst. Phone: 603 653 9948
Asst. Email: mary r. smith@hitchcock.org

Professional Interests:

The research focus of this laboratory is on the immune response to and cell biology of Toxoplasma gondii. This parasite which is perhaps the most common parasitic infection of humans causes congenital disease in the newborn and is a major opportunistic infection in those with AIDS. Our research effort has been directed at understanding the interaction between the parasite and its host. Toxoplasma is able to stimulate both a host protective response and downregulate the immune system in order to survive. Our long term effort is to understand the mechanims of innate immunity to this opportunistic pathogen and how the host protects itself against recurrent chronic infection.

The second major area of interest is understanding the process of attachment, parasite replication and egress from the infected host cell. A variety of immunologic and molecular approaches are utilized to decipher these events during invasion and internalization.

Selected Publications:
 

Begum-Haque S, Christy M, Wang Y, Kasper E, Ochoa-Reparaz J, Smith JY, Haque A, Kasper LH
Glatiramer acetate biases dendritic cells towards an anti-inflammatory phenotype by modulating OPN, IL-17, and RORĪ³t responses and by increasing IL-10 production in experimental allergic encephalomyelitis.
J Neuroimmunol 2013 Jan 15; 254(1-2):117-24
PMID: 23141166

Ochoa-Reparaz J, Mielcarz DW, Begum-Haque S, Kasper LH
Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease.
Ann Neurol 2011 Feb; 69(2):240-7
PMID: 21387369

Ochoa-Reparaz J, Mielcarz DW, Haque-Begum S, Kasper LH
Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora.
Gut Microbes 2010 Mar; 1(2):103-108
PMID: 21326918

Oliver BJ, Kohli E, Kasper LH
Interferon therapy in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of the comparative trials.
J Neurol Sci 2011 Mar 15; 302(1-2):96-105
PMID: 21167504

Begum-Haque S, Christy M, Ochoa-Reparaz J, Nowak EC, Mielcarz D, Haque A, Kasper LH
Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate.
J Neuroimmunol 2011 Mar; 232(1-2):136-44
PMID: 21111489

Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH
Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.
J Immunol 2010 Oct 1; 185(7):4101-8
PMID: 20817872

Foureau DM, Mielcarz DW, Menard LC, Schulthess J, Werts C, Vasseur V, Ryffel B, Kasper LH, Buzoni-Gatel D
TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii.
J Immunol 2010 Jun 15; 184(12):7022-9
PMID: 20488791

Kasper LH, Shoemaker J
Multiple sclerosis immunology: The healthy immune system vs the MS immune system.
Neurology 2010 Jan 5; 74 Suppl 1:S2-8
PMID: 20038759

Begum-Haque S, Sharma A, Christy M, Lentini T, Ochoa-Reparaz J, Fayed IF, Mielcarz D, Haque A, Kasper LH
Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis.
J Neuroimmunol 2010 Feb 26; 219(1-2):47-53
PMID: 20034680

Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH
Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis.
J Immunol 2009 Nov 15; 183(10):6041-50
PMID: 19841183