Lloyd H. Kasper, M.D.
Professor of Medicine
Professor of Microbiology and Immunology
Microbiology and Immunology
Rush Medical College, MD 1975
University of Illinois, MS 1973
University of Illinois, BS 1970
University of Illinois, BA 1970
Dartmouth College MA (honorary) 1994
Lloyd Kasper received his undergraduate degrees in Rhetoric and Zoology from the University of Illinois, Urbana. After completing medical school in Chicago, he received clinical training in Internal Medicine and Neurology. He was appointed to the Dartmouth Medical School faculty in 1981. In addition to his research responsibilities, he is the Director of the Dartmouth-Hitchcock Multiple Sclerosis Clinic.
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth
Dartmouth Medical School
Rubin Bldg 701 HB 7556
1 Medical Center Drive
Lebanon NH 03756
The research focus of this laboratory is on the immune response to and cell biology of Toxoplasma gondii. This parasite which is perhaps the most common parasitic infection of humans causes congenital disease in the newborn and is a major opportunistic infection in those with AIDS. Our research effort has been directed at understanding the interaction between the parasite and its host. Toxoplasma is able to stimulate both a host protective response and downregulate the immune system in order to survive. Our long term effort is to understand the mechanims of innate immunity to this opportunistic pathogen and how the host protects itself against recurrent chronic infection.
The second major area of interest is understanding the process of attachment, parasite replication and egress from the infected host cell. A variety of immunologic and molecular approaches are utilized to decipher these events during invasion and internalization.
Begum-Haque S, Christy M, Wang Y, Kasper E, Ochoa-Reparaz J, Smith JY, Haque A, Kasper LH
Ochoa-Reparaz J, Mielcarz DW, Begum-Haque S, Kasper LH
Ochoa-Reparaz J, Mielcarz DW, Haque-Begum S, Kasper LH
Oliver BJ, Kohli E, Kasper LH
Begum-Haque S, Christy M, Ochoa-Reparaz J, Nowak EC, Mielcarz D, Haque A, Kasper LH
Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH
Foureau DM, Mielcarz DW, Menard LC, Schulthess J, Werts C, Vasseur V, Ryffel B, Kasper LH, Buzoni-Gatel D
Kasper LH, Shoemaker J
Begum-Haque S, Sharma A, Christy M, Lentini T, Ochoa-Reparaz J, Fayed IF, Mielcarz D, Haque A, Kasper LH
Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH