William R Green, Ph.D.
Title(s):
Professor of Microbiology and Immunology
The Elmer R. Pfefferkorn Professor and Chair of the Department of Microbiology and Immunology
Department(s):
Microbiology and Immunology
Education:
Case Western Reserve University, PHD 1977
University of Michigan, BS 1972
Dr. Green's subsequent postdoctoral work was supported by an individual NIH postdoctoral fellowship, and he was a research associate in Immunology at first Johns Hopkins University School of Medicine and then at the Fred Hutchinson Cancer Research Center (FHCRC) and the University of Washington (UW) in Seattle. He became an Assistant Member/Professor at FHCRC and the UW in 1980. Dr. Green joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1983. From 1992-2002 Dr. Green served as Director of the Immunology Program, including the Immunology and Cancer Immunotherapy Program of the Norris Cotton Cancer Center, before becoming Chair of the Microbiology and Immunology (M/I) Department in July, 2002. From January, 2008 through September 2010, he served a one term as Dean of Dartmouth Medical School before returning to chairmanship of the M/I Department, and Director of the Dartmouth Community Medical School.
Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Websites:
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Contact Information:
Dartmouth Medical School
Borwell Research Bldg., HB 7556
1 Medical Center Drive
Lebanon NH 03756
Professional Interests:
T Cell Immune Responses to Retroviral Diseases
The primary interests of the lab focus on cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency. We have been studying resistance to endogenous AKR/Gross virus-induced leukemia mediated by cytotoxic T lymphocyte (CTL) responses. By use of "low leukemia" mouse strains, CTL that readily lyse AKR/Gross retrovirus-induced tumors have been generated. The CTL recognize "type-specific" viral determinants with the major immunodominant viral peptide located in the transmembrane anchor protein encoded by the envelope gene. Other mouse strains of higher leukemia incidence are unable to generate such CTL responses. The mechanism of unresponsiveness include both MHC-dependent mechanisms and apoptosis of effector CTL following interaction with FasL-expressing virus infected cells.
Another area of emphasis is the study of both immunity to the mouse acquired immunodeficiency syndrome (MAIDS) retroviral isolate and the mechanism of retroviral pathogenesis. In this model of HIV induced AIDS, we have raised unique protective CTL to the causative virus. Interestingly, the immunodominant determinant recognized by the CTL is encoded by a previously unrecognized alternative viral translational reading frame. Moreover, this alternative reading frame is extended, and mutagenesis experiments have shown that it exists because its protein product is necessary for viral pathogenesis. We are also interested in novel vaccine approaches, particularly to the Category A biodefense agent, smallpox virus.
Biography:
Dr. Green's subsequent postdoctoral work was supported by an individual NIH postdoctoral fellowship, and he was a research associate in Immunology at first Johns Hopkins University School of Medicine and then at the Fred Hutchinson Cancer Research Center (FHCRC) and the University of Washington (UW) in Seattle. He became an Assistant Member/Professor at FHCRC and the UW in 1980. Dr. Green joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1983. From 1992-2002 Dr. Green served as Director of the Immunology Program, including the Immunology and Cancer Immunotherapy Program of the Norris Cotton Cancer Center, before becoming Chair of the Microbiology and Immunology (M/I) Department in July, 2002. From January, 2008 through September 2010, he served a one term as Dean of Dartmouth Medical School before returning to chairmanship of the M/I Department, and Director of the Dartmouth Community Medical School.
Selected Publications: |
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Green KA, Cook WJ, Green WR Li W, Green WR Li W, Carlson TL, Green WR Rutkowski MR, Stevens CA, Green WR Carlson TL, Green KA, Green WR Rutkowski MR, Ho O, Green WR Green KA, Okazaki T, Honjo T, Cook WJ, Green WR Ho O, Green WR Li W, Green WR Rich RF, Green WR |
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