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James D. Gorham, M.D., Ph.D.

Adjunct Professor of Pathology
Adjunct Professor of Microbiology and Immunology

Microbiology and Immunology

New York University School of Medicine, MD 1992
New York University, PHD 1991
New York University, MS 1989
Haverford College, BA 1984

Dr. Gorham received his B.A. in Biology from Haverford College in 1984, his Ph.D. in Biochemistry from New York University in 1991 and his M.D. from New York University in 1992. He did postdoctoral training at Washington University, where he also completed a residency in Clinical Pathology and was Chief Resident (1997 - 1998). In 1998, he joined Dartmouth Medical School as Assistant Professor in the Department of Pathology with a secondary appointment in the Department of Microbiology and Immunology. He completed a Clinical Fellowship in Transfusion Medicine in 2009 at DHMC. He was promoted to Associate Professor in 2004 and to Professor in 2010.

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Contact Information:

The Geisel School of Medicine at Dartmouth
Department of Pathology, HB 7600
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-650-8373
Fax: 603-650-6166
Email: James.D.Gorham@Dartmouth.EDU

Asst. Phone: 603-650-8266

Professional Interests:

Transfusion Medicine
Mouse genetics
Genetic regulation of red blood cell storage
Liver Tolerance and Autoimmunity
The microbiota and regulation of liver injury

Courses Taught:

Organizer and lecturer of Autoimmunity block, DMS MCB Graduate Course 146 (Immunotherapy)
Geisel Year 1 - General Pathology

Selected Publications:


Rapid ADAMTS13 availability impacts treatment for microangiopathic hemolytic anemia and thrombocytopenia.
Martin IW, Katus MC, Martin CB, Szczepiorkowski ZM, Gorham JD, Dunbar NM
J Clin Apher. 2015 Aug 31; doi: 10.1002/jca.21419. Epub 2015 Aug 31.
PMID: 26332753

Cirrhosis and dysbiosis: New insights from next-generation sequencing.
Gorham J, Gleeson M
Hepatology. 2015 Aug 27; doi: 10.1002/hep.28133. Epub 2015 Aug 27.
PMID: 26313376

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Muller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23.
PMID: 25713392

Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-β and MyD88.
Maria A, English KA, Gorham JD
J Immunol Res. 2014;2014:279736. doi: 10.1155/2014/279736. Epub 2014 Aug 7.
PMID: 25177709

The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.
Celaj S, Gleeson MW, Deng J, O'Toole GA, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA, Gorham JD
Lab Invest. 2014 Sep;94(9):938-49. doi: 10.1038/labinvest.2014.93. Epub 2014 Jul 28.
PMID: 25068658

1 + 1 = 3: Development and validation of a SNP-based algorithm to identify genetic contributions from three distinct inbred mouse strains.
Gorham JD, Ranson MS, Smith JC, Gorham BJ, Muirhead KA
J Biomol Tech. 2012 Dec;23(4):136-46. doi: 10.7171/jbt.12-2304-004.
PMID: 23204929

Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5.
Cripps JG, Celaj S, Burdick M, Strieter RM, Gorham JD
Lab Invest. 2012 Oct;92(10):1461-71. doi: 10.1038/labinvest.2012.104. Epub 2012 Aug 20.
PMID: 22906987

MDSC in autoimmunity.
Cripps JG, Gorham JD
Int Immunopharmacol. 2011 Jul;11(7):789-93. doi: 10.1016/j.intimp.2011.01.026. Epub 2011 Feb 21.
PMID: 21310255

Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver.
Cripps JG, Wang J, Maria A, Blumenthal I, Gorham JD
Hepatology. 2010 Oct;52(4):1350-9. doi: 10.1002/hep.23841.
PMID: 20803559

The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis.
Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield ML, Gorham JD
Liver Int. 2009 Oct;29(9):1307-15. doi: 10.1111/j.1478-3231.2009.02028.x. Epub 2009 Apr 16.
PMID: 19490417