James D. Gorham, M.D., Ph.D.
Title(s):
Professor of Pathology
Professor of Microbiology and Immunology
Department(s):
Pathology
Microbiology and Immunology
Education:
New York University School of Medicine, MD 1992
New York University, PHD 1991
New York University, MS 1989
Haverford College, BA 1984
Dr. Gorham received his B.A. in Biology from Haverford College in 1984, his Ph.D. in Biochemistry from New York University in 1991 and his M.D. from New York University in 1992. He did postdoctoral training at Washington University, where he also completed a residency in Clinical Pathology and was Chief Resident (1997 - 1998). In 1998, he joined Dartmouth Medical School as Assistant Professor in the Department of Pathology with a secondary appointment in the Department of Microbiology and Immunology. He was promoted to Associate Professor in 2004 and to Professor in 2010.
Programs:
Center for Continuing Education in the Health Sciences
Curriculum Vitae:
Gorham_J_CV_2009-02-12.pdf
NIH Biosketch:
Gorham_J_BIO_2009-02-12.pdf
Websites:
http:
http:
Contact Information:
Dartmouth Medical School
Department of Pathology, HB 7600
1 Medical Center Drive
Lebanon NH 03756
Phone: 603-650-8373
Fax: 603-650-6120
Email: James.D.Gorham@Dartmouth.EDU
Assistant: Christine Kretowicz
Asst. Phone: 603-650-8266
Asst. Email: Christine.Kretowicz@Dartmouth.edu
Professional Interests:
REGULATION OF T HELPER CELLS IN THE HEPATIC IMMUNE SYSTEM
The principal research goal in our laboratory is to understand the biological mechanisms regulating T helper cells, immune tolerance, and autoimmunity in the liver.
Our laboratory has shown that TGF-beta1 is a master regulator of liver immunity. TGF-beta1-deficient mice on the BALB/c background develop an aggressive inflammatory liver pathology that mimics many aspects of the human disease autoimmune hepatitis (AIH). We have shown that liver disease in BALB/c-TGF-beta1-/- mice is dependent upon the genetic background of the mouse, CD4+ T helper cells, and the inflammatory Th1 cytokine IFN-gamma. Our goals are to define the genetic, cellular, and molecular determinants of disease in this mouse model of AIH.
Because of the central role of TGF-beta1 in regulating Th1 mediated autoimmune disease in the liver, we are examining the mechanisms by which TGF-beta1 regulates T helper cell function in vitro. In particular, we are using a variety of approaches to better understand the effects of TGF-beta1 on T helper cell differentiation along the Th1 differentiation pathway. Recent data from our laboratory indicate that TGF-beta1 utilizes multiple mechanisms to inhibit the expression of hepatotoxic Th1 cytokines such as IFN-gamma and TNF-alpha.
Several additional projects are underway to better understand the behavior, trafficking, and regulation of T helper cells in the liver. We are using TCR transgenic mice to understand how antigen stimulation regulates T cells in the liver. In addition we are probing the cellular and molecular characteristics of liver T cells to gain insight into their unique properties.
Grant Information:
"Chemokines in Autoimmune Hepatitis" R01 AI078195
Courses Taught:
Organizer and lecturer of Autoimmunity block, DMS MCB Graduate Course 146 (Immunotherapy)
Lecturer, DMS Year 1 - General Pathology
Small group discussion leader, DMS Year 1 - Medical Immunology
Selected Publications: |
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Gorham JD, Ranson MS, Smith JC, Gorham BJ, Muirhead KA Cripps JG, Celaj S, Burdick M, Strieter RM, Gorham JD Cripps JG, Gorham JD Cripps JG, Wang J, Maria A, Blumenthal I, Gorham JD Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield ML, Gorham JD Robinson RT, Wang J, Cripps JG, Milks MW, English KA, Pearson TA, Gorham JD Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ Robinson RT, Gorham JD Park IK, Letterio JJ, Gorham JD Robinson RT, French MA, Kitzmiller TJ, Gorham JD |
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