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James D. Gorham, M.D., Ph.D.

Title(s):
Professor of Pathology
Professor of Microbiology and Immunology

Department(s):
Pathology
Microbiology and Immunology

Education:
New York University School of Medicine, MD 1992
New York University, PHD 1991
New York University, MS 1989
Haverford College, BA 1984

Dr. Gorham received his B.A. in Biology from Haverford College in 1984, his Ph.D. in Biochemistry from New York University in 1991 and his M.D. from New York University in 1992. He did postdoctoral training at Washington University, where he also completed a residency in Clinical Pathology and was Chief Resident (1997 - 1998). In 1998, he joined Dartmouth Medical School as Assistant Professor in the Department of Pathology with a secondary appointment in the Department of Microbiology and Immunology. He completed a Clinical Fellowship in Transfusion Medicine in 2009 at DHMC. He was promoted to Associate Professor in 2004 and to Professor in 2010.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Contact Information:

The Geisel School of Medicine at Dartmouth
Department of Pathology, HB 7600
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-650-8373
Fax: 603-650-6166
Email: James.D.Gorham@Dartmouth.EDU

Asst. Phone: 603-650-8266


Professional Interests:

Transfusion Medicine
Mouse genetics
Genetic regulation of red blood cell storage
Liver Tolerance and Autoimmunity
The microbiota and regulation of liver injury

Courses Taught:

Organizer and lecturer of Autoimmunity block, DMS MCB Graduate Course 146 (Immunotherapy)
Geisel Year 1 - General Pathology


Selected Publications:

 

Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Muller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC
Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Proc Natl Acad Sci U S A 2015 Feb 23;
PMID: 25713392

Maria A, English KA, Gorham JD
Appropriate development of the liver Treg compartment is modulated by the microbiota and requires TGF-β and MyD88.
J Immunol Res 2014; 2014:279736
PMID: 25177709

Celaj S, Gleeson MW, Deng J, O'Toole GA, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA, Gorham JD
The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.
Lab Invest 2014 Sep; 94(9):938-49
PMID: 25068658

Gorham JD, Ranson MS, Smith JC, Gorham BJ, Muirhead KA
1 + 1 = 3: Development and validation of a SNP-based algorithm to identify genetic contributions from three distinct inbred mouse strains.
J Biomol Tech 2012 Dec; 23(4):136-46
PMID: 23204929

Cripps JG, Celaj S, Burdick M, Strieter RM, Gorham JD
Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5.
Lab Invest 2012 Oct; 92(10):1461-71
PMID: 22906987

Cripps JG, Gorham JD
MDSC in autoimmunity.
Int Immunopharmacol 2011 Jul; 11(7):789-93
PMID: 21310255

Cripps JG, Wang J, Maria A, Blumenthal I, Gorham JD
Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver.
Hepatology 2010 Oct; 52(4):1350-9
PMID: 20803559

Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield ML, Gorham JD
The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis.
Liver Int 2009 Oct; 29(9):1307-15
PMID: 19490417

Robinson RT, Wang J, Cripps JG, Milks MW, English KA, Pearson TA, Gorham JD
End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas.
J Immunol 2009 Mar 1; 182(5):3278-84
PMID: 19234226

Ahonen CL, Wasiuk A, Fuse S, Turk MJ, Ernstoff MS, Suriawinata AA, Gorham JD, Kedl RM, Usherwood EJ, Noelle RJ
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood 2008 Mar 15; 111(6):3116-25
PMID: 18202224