David J. Bzik, Ph.D.
Professor of Microbiology and Immunology
Microbiology and Immunology
Pennsylvania State University, PHD 1983
Pennsylvania State University, MS 1980
Lehigh University, BA 1977
Dr. Bzik received his undergraduate degree in Biology from Lehigh University in 1977, and his Ph.D. degree in Biophysics from the Pennsylvania State University in 1983. After postdoctoral work as a European Molecular Biology Organization long-term fellow at the MRC Virology Unit at Glasgow University, Dr. Bzik joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1988.
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Borwell Research Bldg. HB 7556
1 Medical Center Drive
Lebanon NH 03756
GENETIC ANALYSIS OF HOST-PARASITE INTERACTIONS
Our major research interests involve the molecular mechanisms of parasite pathogenesis. We focus on the protozoan parasites Toxoplasma gondii and Plasmodium falciparum. These apicomplexan parasites represent a paradigm of obligate intracellular infectious disease agents. Plasmodium falciparum causes a devastating form of human malaria which infects vast numbers of people and causes significant morbidity (adults and children) and mortality (mainly children). Toxoplasma gondii infection causes severe congenital defects in infants and death in HIV/AIDS patients. Current research projects include the following: developmental regulation of parasite virulence factors; identification of new parasite virulence determinants; development of new tools to facilitate genetic analysis of parasite pathogens; mechanisms, regulation and drug discovery in pyrimidine and purine acquisition pathways; design of vaccine components based on secreted antigens; novel parasite enzymes: mechanisms, regulation and drug discovery; creation and evaluation of live attenuated parasite vaccines; taming and targeting parasites for cancer gene therapy. Visit the Molecular Pathogenesis Website.
Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.
Attenuated Toxoplasma gondii Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations.
Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection.
Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages.
Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator.
The Toxoplasma gondii cyst wall protein CST1 is critical for cyst wall integrity and promotes bradyzoite persistence.
Non-replicating <i>Toxoplasma gondii</i> reverses tumor-associated immunosuppression.
Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.
Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines.
Genetic manipulation in Δku80 strains for functional genomic analysis of Toxoplasma gondii.