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David J. Bzik, PhD

Title(s):
Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Pennsylvania State University, PHD 1983
Pennsylvania State University, MS 1980
Lehigh University, BA 1977

Dr. Bzik received his undergraduate degree in Biology from Lehigh University in 1977, and his Ph.D. degree in Biophysics from the Pennsylvania State University in 1983. After postdoctoral work as a European Molecular Biology Organization long-term fellow at the MRC Virology Unit at Glasgow University, Dr. Bzik joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1988.

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/

Contact Information:

Dartmouth Medical School
Borwell Research Bldg. HB 7556
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-650-7951
Fax: 603-650-6223
Email: David.J.Bzik@Dartmouth.EDU


Professional Interests:

GENETIC ANALYSIS OF HOST-PARASITE INTERACTIONS

Our major research interests involve the molecular mechanisms of parasite pathogenesis. We focus on the protozoan parasites Toxoplasma gondii and Plasmodium falciparum. These apicomplexan parasites represent a paradigm of obligate intracellular infectious disease agents. Plasmodium falciparum causes a devastating form of human malaria which infects vast numbers of people and causes significant morbidity (adults and children) and mortality (mainly children). Toxoplasma gondii infection causes severe congenital defects in infants and death in HIV/AIDS patients. Current research projects include the following: developmental regulation of parasite virulence factors; identification of new parasite virulence determinants; development of new tools to facilitate genetic analysis of parasite pathogens; mechanisms, regulation and drug discovery in pyrimidine and purine acquisition pathways; design of vaccine components based on secreted antigens; novel parasite enzymes: mechanisms, regulation and drug discovery; creation and evaluation of live attenuated parasite vaccines; taming and targeting parasites for cancer gene therapy. Visit the Molecular Pathogenesis Website.


Selected Publications:

 

Serial Dissection of Parasite Gene Families.
Bzik DJ
Infect Immun. 2016 May;84(5):1252-4. doi: 10.1128/IAI.00175-16. Epub 2016 Apr 22.
PMID: 26953326

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.
Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N
Cell Rep. 2015 Dec 15;13(10):2273-86. doi: 10.1016/j.celrep.2015.11.001. Epub 2015 Nov 25.
PMID: 26628378

Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.
Leroux LP, Nishi M, El-Hage S, Fox BA, Bzik DJ, Dzierszinski FS
Infect Immun. 2015 Oct;83(10):3865-80. doi: 10.1128/IAI.00415-15. Epub 2015 Jul 20.
PMID: 26195549

Attenuated Toxoplasma gondii Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations.
Sanders KL, Fox BA, Bzik DJ
Cancer Immunol Res. 2015 Aug;3(8):891-901. doi: 10.1158/2326-6066.CIR-14-0235. Epub 2015 Mar 24.
PMID: 25804437

Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection.
Fox BA, Bzik DJ
Infect Immun. 2015 May;83(5):2148-55. doi: 10.1128/IAI.02756-14. Epub 2015 Mar 16.
PMID: 25776745

Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages.
Leroux LP, Dasanayake D, Rommereim LM, Fox BA, Bzik DJ, Jardim A, Dzierszinski FS
Int J Parasitol. 2015 Apr;45(5):319-32. doi: 10.1016/j.ijpara.2015.01.003. Epub 2015 Feb 24.
PMID: 25720921

Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator.
Mouveaux T, Oria G, Werkmeister E, Slomianny C, Fox BA, Bzik DJ, Tomavo S
PLoS One. 2014;9(8):e105820. doi: 10.1371/journal.pone.0105820. Epub 2014 Aug 25.
PMID: 25153525

The Toxoplasma gondii cyst wall protein CST1 is critical for cyst wall integrity and promotes bradyzoite persistence.
Tomita T, Bzik DJ, Ma YF, Fox BA, Markillie LM, Taylor RC, Kim K, Weiss LM
PLoS Pathog. 2013;9(12):e1003823. doi: 10.1371/journal.ppat.1003823. Epub 2013 Dec 26.
PMID: 24385904

Non-replicating <i>Toxoplasma gondii</i> reverses tumor-associated immunosuppression.
Fox BA, Sanders KL, Bzik DJ
Oncoimmunology. 2013 Nov 1;2(11):e26296. Epub 2013 Oct 9.
PMID: 24353916

Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.
Patil V, Zhao Y, Shah S, Fox BA, Rommereim LM, Bzik DJ, Yap GS
Int J Parasitol. 2014 Feb;44(2):161-4. doi: 10.1016/j.ijpara.2013.08.003. Epub 2013 Sep 29.
PMID: 24083945