David J. Bzik, Ph.D.
Professor of Microbiology and Immunology
Microbiology and Immunology
Pennsylvania State University, PHD 1983
Pennsylvania State University, MS 1980
Lehigh University, BA 1977
Dr. Bzik received his undergraduate degree in Biology from Lehigh University in 1977, and his Ph.D. degree in Biophysics from the Pennsylvania State University in 1983. After postdoctoral work as a European Molecular Biology Organization long-term fellow at the MRC Virology Unit at Glasgow University, Dr. Bzik joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1988.
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Borwell Research Bldg. HB 7556
1 Medical Center Drive
Lebanon NH 03756
GENETIC ANALYSIS OF HOST-PARASITE INTERACTIONS
Our major research interests involve the molecular mechanisms of parasite pathogenesis. We focus on the protozoan parasites Toxoplasma gondii and Plasmodium falciparum. These apicomplexan parasites represent a paradigm of obligate intracellular infectious disease agents. Plasmodium falciparum causes a devastating form of human malaria which infects vast numbers of people and causes significant morbidity (adults and children) and mortality (mainly children). Toxoplasma gondii infection causes severe congenital defects in infants and death in HIV/AIDS patients. Current research projects include the following: developmental regulation of parasite virulence factors; identification of new parasite virulence determinants; development of new tools to facilitate genetic analysis of parasite pathogens; mechanisms, regulation and drug discovery in pyrimidine and purine acquisition pathways; design of vaccine components based on secreted antigens; novel parasite enzymes: mechanisms, regulation and drug discovery; creation and evaluation of live attenuated parasite vaccines; taming and targeting parasites for cancer gene therapy. Visit the Molecular Pathogenesis Website.
Leroux LP, Dasanayake D, Rommereim LM, Fox BA, Bzik DJ, Jardim A, Dzierszinski FS
Mouveaux T, Oria G, Werkmeister E, Slomianny C, Fox BA, Bzik DJ, Tomavo S
Tomita T, Bzik DJ, Ma YF, Fox BA, Markillie LM, Taylor RC, Kim K, Weiss LM
Fox BA, Sanders KL, Bzik DJ
Patil V, Zhao Y, Shah S, Fox BA, Rommereim LM, Bzik DJ, Yap GS
Fox BA, Sanders KL, Chen S, Bzik DJ
Rommereim LM, Hortua Triana MA, Falla A, Sanders KL, Guevara RB, Bzik DJ, Fox BA
Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ
Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S
Fox BA, Falla A, Rommereim LM, Tomita T, Gigley JP, Mercier C, Cesbron-Delauw MF, Weiss LM, Bzik DJ