Jay C. Dunlap, PhD
Title(s)
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor
Department(s)
Molecular and Systems Biology
Biochemistry and Cell Biology
Education
Harvard University, Ph.D. 1979
Programs
Molecular and Cellular Biology Graduate Programs
Websites
http:
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Contact Information
Dartmouth Medical School
HB 7400
Hanover NH 03755
Office: 603-650-1907
Phone: 603-650-1108
Fax: 603-650-1233
Email: jay.dunlap@Dartmouth.edu
Assistant: Cheryl Bush
Asst. Phone: 603-650-1907
Asst. Email: genetics@dartmouth.edu
Professional Interests
Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.
Grant Information
Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.
Transcriptional rewiring of an evolutionarily conserved circadian clock. Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock. Acetylation of WCC is dispensable for the core circadian clock but differentially regulates acute light responses in Neurospora. A crucial role for dynamic expression of components encoding the negative arm of the circadian clock. Domains required for the interaction of the central negative element FRQ with its transcriptional activator WCC within the core circadian clock of Neurospora. A crucial role for dynamic expression of components encoding the negative arm of the circadian clock. Domains Required for FRQ-WCC Interaction within the Core Circadian Clock of Neurospora. Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability. Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation. Optimized fluorescent proteins for 4-color and photoconvertible live-cell imaging in Neurospora crassa. |
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