Nadeem Khan, M.Sc., Ph.D.
Title(s):
Associate Professor of Radiology
EPR Center for Viable Systems, Department of Diagnostic Radiology
Dartmouth Medical School, Hanover, NH 03755
&
Investigator, Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
Lebanon, NH 03756
Department(s):
Radiology
Education:
Ph.D. (Chemistry): 1998
M.Sc. (Chemistry): 1992
DICE (Diploma in Industrial & Computer Electronics): 1990
B.Sc. (Physics, Chemistry, Mathematics): 1989
Programs:
EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center
Websites:
http:
Contact Information:
Dartmouth Medical School
HB 7785 VAIL
Hanover NH 03755
Office: 640 Rubin, Norris Cotton Cancer Center
Phone: 603 653 3591
Fax: 603 650 1717
Email: nadeem.khan@dartmouth.edu
Professional Interests:
Application of EPR oximetry to assess and repeatedly follow tumor pO2 during therapies and use this vital information to optimize therapeutic outcome
Clinical application of EPR oximetry for diagnosis and prognosis of peripheral vascular diseases
Potential application of checkpoint inhibitors to increase malignant cell death during chemoradiation
Assessment of redox status and oxygen concentration using soluble probes such as nitroxides, spin trapping of free radicals etc
Grant Information:
ONGOING
RO1 CA120919 Khan (PI) 07/01/06 – 05/31/11
National Institutes of Health
Oxygen Guided Hypofractionated Radiotherapy for Gliomas
The overall goal is to demonstrate that the efficacy of the hypofractionated radiotherapy can be significantly enhanced by irradiating at times of optimal tumor oxygenation and that the use of hyperoxic therapies in conjunction with hypofractionated radiotherapy can be optimized by use of the information on oxygen levels in the tumors.
014519 Khan and Eastman (PI) 07/01/10 – 06/30/11
EISAI Inc. Andover, MA
Effect of a PARP inhibitor on tumor oxygenation and growth
Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that signals DNA damage to repair proteins by synthesizing ADP-ribose polymers on the nuclear proteins. Consequently, inhibition of DNA repair by PARP inhibitors might enhance tumor cell death during chemotherapy and radiotherapy. The goal is to investigate the effect of a PARP inhibitor on the tissue oxygenation and growth of the gliomas when treated alone or in combination with chemotherapy.
30.058.287103 Khan and Eastman (PI) 02/01/11- 01/31/12
Norris Cotton Cancer Center, DHMC, Lebanon, NH
Oximetry-guided optimization of chemoradiation for gliomas
The overall goal is to enhance therapeutic outcome of glioma by efficaciously combining DNA damaging agents (gemcitabine and/or radiation) with SCH900776, an inhibitor of cell cycle checkpoint kinase 1 (Chk1). This will be achieved in part through an increase in the tumor pO2 (partial pressure of oxygen), which will further increase the efficacy of chemoradiation. The changes in the tumor pO2 are likely to provide an early indication of tumor response to therapy.
COMPLETED
R21DK072112 Khan (PI) 07/01/06 - 06/30/10
National Institutes of Health
Development of EPR and NIR Oximetry for Diabetic Foot
The major goal of this project is to develop and apply two emerging techniques - Electron Paramagnetic Resonance (EPR) and Near Infrared spectroscopy (NIR) for oximetry to characterize and follow tissue oxygenation in the diabetic foot and provide data that can improve the management of the serious and widespread complication of peripheral vascular disease.
R21 CA118069 Khan (PI) 07/01/06 - 06/30/10
National Institutes of Health
Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
The overall goal of this project is to demonstrate, under realistic conditions, that in vivo EPR oximetry can provide repetitive data on tumor oxygenation during the course of therapy and that this can be used to enhance therapeutic outcome.
P01 EB2180 Swartz(PI) 07/01/02 - 06/30/07
Measurement of pO2 in vivo and in vitro
The goal was to develop EPR oximetric material and the oximetry technique to investigate tissue pO2 in various pathologies including cancer.
Role: Co-Investigator
Biography:
POSITIONS AND EMPLOYMENT
1993-1996
Junior Research Fellow, North-Eastern Hill University, Shillong, India
1996-1997
Senior Research Fellow, North-Eastern Hill University, Shillong, India
1998-1999
Research Associate, University of Basel, Switzerland
Sept. 1999-2002
Postdoctoral Fellow, Dartmouth Medical School, Hanover, NH, USA
2007 – present
Investigator, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH
2002 - June, 2008
Research Assistant Professor, Dartmouth Medical School, NH, USA
July, 2009 - present
Research Associate Professor, Dartmouth Medical School, NH, USA
PROFESSIONAL MEMBERSHIPS
2003 -
Member, International Society on Oxygen Transport to Tissue (ISOTT)
2005 -
Member, International EPR Society (IES)
2007 -
Member, Radiation Research Society (RRS)
HONORS/AWARDS
1993
Junior Research Fellowship, Department of Atomic Energy, New Delhi, India
1996
Senior Research Fellowship, Department of Atomic Energy, New Delhi, India
1999
Best Poster Award, 32nd Annual International ESR Conference, University of York, U.K.
2003
Melvin H. Knisely Award by International Society on Oxygen Transport to Tissue (ISOTT), Rochester, New York
2005
Young Investigator Award, International Conference/Workshop on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems, September 4-8, 2005, Ohio, USA
Selected Publications: |
|
Khan N, Mupparaju S, Hou H, Williams BB, Swartz H Hou H, Dong R, Li H, Williams B, Lariviere JP, Hekmatyar SK, Kauppinen RA, Khan N, Swartz H Hou H, Dong R, Lariviere JP, Mupparaju SP, Swartz HM, Khan N Khan N, Blinco JP, Bottle SE, Hosokawa K, Swartz HM, Micallef AS Mupparaju S, Hou H, Lariviere JP, Swartz H, Jounaidi Y, Khan N Mupparaju S, Hou H, Lariviere JP, Swartz HM, Khan N Hou H, Li H, Dong R, Mupparaju S, Khan N, Swartz H Khan N, Mupparaju S, Hekmatyar SK, Hou H, Lariviere JP, Demidenko E, Gladstone DJ, Kauppinen RA, Swartz HM Hou H, Abramovic Z, Lariviere JP, Sentjurc M, Swartz H, Khan N Williams BB, Khan N, Zaki B, Hartford A, Ernstoff MS, Swartz HM |
|