Gustav E. Lienhard, PhD
Professor of Biochemistry and Cell Biology
Biochemistry and Cell Biology
Amherst College, BA 1959Yale University, PHD 1964
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Hanover NH 03755
Cellular signaling pathways; hormonal regulation of membrane trafficking. Current research is focused on two areas: the pathways of signaling from the insulin receptor, which is a tyrosine kinase, and the stimulation of glucose transport by insulin, an effect which involves the fusion of intracellular vesicles containing glucose transporters with the plasma membrane.
Keller, S.R. and Lienhard, G.E. Insulin Signalling: The Role of Insulin Receptor Substrate 1. Trends in Cell Biol. 4, 115-119 (1994).
Lienhard, G.E., Slot, J.W., James, D.E., and Mueckler, M. How Cells Absorb Glucose. Scientific American, 266, 86-91 (1992).
Keller, S.R., Scott, H.M., Mastick, C.C., Aebersold,R., and Lienhard, G.E. Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles. J. Biol. Chem. 270, 23612-23618.