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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. EPR dosimetry.

Grant Information:

NIH/PO1 GM51630-05 Physics Consultant
NIH / NCI 1R43CA78005-01 - Phase II Co-Investigator
ACS grant #IRG82-003016IRG IRG-157M PI
NIH/NCI P01 CA23108-35 Co-director Radiation Shared Resource
NIH/NCI R43 CA103567-01 Co-Investigator

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Algorithm development for intrafraction radiotherapy beam edge verification from Cherenkov imaging.
Snyder C, Pogue BW, Jermyn M, Tendler I, Andreozzi JM, Bruza P, Krishnaswamy V, Gladstone DJ, Jarvis LA
J Med Imaging (Bellingham). 2018 Jan;5(1):015001. doi: 10.1117/1.JMI.5.1.015001. Epub 2018 Jan 2.
PMID: 29322071

Cherenkov-excited Multi-Fluorophore Sensing in Tissue-Simulating Phantoms and In Vivo.
Dsouza A, Lin H, Gunn JR, Gladstone DJ, Jarvis LA, Pogue BW
Radiat Res. 2017 Dec 18; doi: 10.1667/RR14943.1. Epub 2017 Dec 18.
PMID: 29251551

Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer.
Hoopes PJ, Mazur CM, Osterberg B, Song A, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Fiering SN
Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb;10066 pii: 100660G. doi: 10.1117/12.2256062. Epub 2017 Feb 20.
PMID: 29203952

Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer.
Hoopes PJ, Moodie KL, Petryk AA, Petryk JD, Sechrist S, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Rajan A, Dugat D, Crary-Burney M, Fiering SN
Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb;10066 pii: 1006605. doi: 10.1117/12.2256213. Epub 2017 Feb 22.
PMID: 29203951

Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue.
Zhang R, Glaser AK, Andreozzi J, Jiang S, Jarvis LA, Gladstone DJ, Pogue BW
J Biophotonics. 2016 Aug 10; doi: 10.1002/jbio.201500344. Epub 2016 Aug 10.
PMID: 27507213

Dose Specification for NRG Radiation Therapy Trials.
Gladstone DJ, Kry SF, Xiao Y, Chetty IJ
Int J Radiat Oncol Biol Phys. 2016 Aug 1;95(5):1344-1345. doi: 10.1016/j.ijrobp.2016.03.044. Epub 2016 Apr 7.
PMID: 27479721

Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation.
Lin H, Zhang R, Gunn JR, Esipova TV, Vinogradov S, Gladstone DJ, Jarvis LA, Pogue BW
Phys Med Biol. 2016 May 21;61(10):3955-68. doi: 10.1088/0031-9155/61/10/3955. Epub 2016 Apr 27.
PMID: 27120085

Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy.
Andreozzi JM, Zhang R, Gladstone DJ, Williams BB, Glaser AK, Pogue BW, Jarvis LA
Med Phys. 2016 Feb;43(2):993-1002. doi: 10.1118/1.4939880.
PMID: 26843259

Quantitative analysis of brass compensators for commissioning of the Pinnacle planning system for IMRT.
Gates LL, Gladstone DJ
J Appl Clin Med Phys. 2015 Nov 8;16(6):130–138. doi: 10.1120/jacmp.v16i6.5531. Epub 2015 Nov 8.
PMID: 26699564

Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications.
Glaser AK, Zhang R, Andreozzi JM, Gladstone DJ, Pogue BW
Phys Med Biol. 2015 Sep 7;60(17):6701-18. doi: 10.1088/0031-9155/60/17/6701. Epub 2015 Aug 13.
PMID: 26270125