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Margaret Rita Karagas, PhD

Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Community and Family Medicine

University of Washington, PhD 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences


Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu

Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.

Selected Publications:


Fetal-Sex Dependent Genomic Responses in the Circulating Lymphocytes of Arsenic-Exposed Pregnant Women in New Hampshire.
Bommarito PA, Martin E, Smeester L, Palys T, Baker ER, Karagas MR, Fry RC
Reprod Toxicol. 2017 Aug 6; pii: S0890-6238(17)30187-9. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
PMID: 28793237

Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation.
Kuklinski LF, Li S, Karagas MR, Weng WK, Kwong BY
J Am Acad Dermatol. 2017 Aug 2; pii: S0190-9622(17)31934-5. doi: 10.1016/j.jaad.2017.06.032. Epub 2017 Aug 2.
PMID: 28780363

Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain.
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, Garcia de la Hera M, Sunyer J, Casas M, Riaño-Galan I, Tardon A, Llop S, Amoros R, Karagas MR, Meharg AA
Environ Res. 2017 Jul 31;159:69-75. doi: 10.1016/j.envres.2017.07.046. Epub 2017 Jul 31.
PMID: 28772151

<b>Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies</b>.
Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska MM, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teiltelbaum SL, Amos CI
Cancer Epidemiol Biomarkers Prev. 2017 Jul 14; pii: cebp.0459.2017. doi: 10.1158/1055-9965.EPI-17-0459. Epub 2017 Jul 14.
PMID: 28710076

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes.
Everson TM, Kappil M, Hao K, Jackson BP, Punshon T, Karagas MR, Chen J, Marsit CJ
Environ Res. 2017 Oct;158:233-244. doi: 10.1016/j.envres.2017.06.016. Epub 2017 Jul 3.
PMID: 28662449

Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures.
Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC
PLoS One. 2017;12(6):e0179606. doi: 10.1371/journal.pone.0179606. Epub 2017 Jun 29.
PMID: 28662050

Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case-Control Study (New England, USA).
Beane Freeman LE, Cantor KP, Baris D, Nuckols JR, Johnson A, Colt JS, Schwenn M, Ward MH, Lubin JH, Waddell R, Hosain GM, Paulu C, McCoy R, Moore LE, Huang AT, Rothman N, Karagas MR, Silverman DT
Environ Health Perspect. 2017 Jun 21;125(6):067010. doi: 10.1289/EHP89. Epub 2017 Jun 21.
PMID: 28636529

Distinct arsenic metabolites following seaweed consumption in humans.
Taylor VF, Li Z, Sayarath V, Palys TJ, Morse KR, Scholz-Bright RA, Karagas MR
Sci Rep. 2017 Jun 20;7(1):3920. doi: 10.1038/s41598-017-03883-7. Epub 2017 Jun 20.
PMID: 28634348

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.
Winterbottom EF, Koestler DC, Fei DL, Wika E, Capobianco AJ, Marsit CJ, Karagas MR, Robbins DJ
Environ Health. 2017 Jun 14;16(1):59. doi: 10.1186/s12940-017-0267-8. Epub 2017 Jun 14.
PMID: 28615018

Wood Stove Pollution in the Developed World: A Case to Raise Awareness Among Pediatricians.
Rokoff LB, Koutrakis P, Garshick E, Karagas MR, Oken E, Gold DR, Fleisch AF
Curr Probl Pediatr Adolesc Health Care. 2017 Jun;47(6):123-141. doi: 10.1016/j.cppeds.2017.04.001. Epub 2017 Jun 2.
PMID: 28583817