Yina H. Huang, PhD
Title(s)
Professor of Microbiology and Immunology
Professor of Pathology and Laboratory Medicine
Department(s)
Microbiology and Immunology
Pathology and Laboratory Medicine
Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Websites
http:
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Contact Information
Email: Yina.H.Huang@Dartmouth.edu
Professional Interests
We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.
Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection. Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect. In the right place at the right time: tissue-resident memory T cells in immunity to cancer. Toward high-throughput engineering techniques for improving CAR intracellular signaling domains. Cell type-specific Interaction Analysis using Doublets in scRNA-seq (CIcADA). Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors. Life support for transitory exhausted CTLs. Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma. IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca(2+) through the noncanonical STAT3 pathway. Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells. |
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