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Tim Lahey, MD

Title(s):
Associate Professor of Medicine
Associate Professor of The Dartmouth Institute
Associate Professor of Medical Education

Department(s):
Medicine
The Dartmouth Institute
Medical Education

Education:
AB, Georgetown University, 1990
MD, Duke University, 1998
MMSc, Harvard Medical School, 2007
Medicine Residency, University of Utah, 1998-2001
Chief Resident, University of Utah, 2001-2002
ID Fellowship, Beth Israel Deaconess MC, 2002-2005
Research Fellowship, Massachusetts General Hosp, 2003-2005

Programs:
Academy of Master Faculty Educators
SYNERGY
The Dartmouth Institute for Health Policy and Clinical Practice

Websites:
http://www.medmurmurs.com

Contact Information:

Infectious Diseases & Int'l Health
One Medical Center Drive
Lebanon NH 03756

Office: (603) 650-6060
Fax: (603) 650-6110
Email: Timothy.Lahey@Dartmouth.edu

Assistant: Diane Kiernan
Asst. Email: Diane.K.Kiernan@Hitchcock.org


Professional Interests:

Health education. As a course director, co-director of the ethics & humanities theme, head of the Geisel curriculum redesign 2011-2015, chair of the Geisel Academy of Master Educators 2016, co-director of the 14-course sequence in the second year of the medical school called Scientific Basis of Medicine, and director of education at The Dartmouth Institute, my prime goal is to enhance health relevance and soul in medical and public health education.

HIV/Tuberculosis Immunology. Through the Dar Dar Trial, the largest trial of a new TB vaccine candidate in the world to date led by PI Ford Von Reyn, we have analyzed how spontaneous and vaccine-mediated immune responses protect HIV-infected adults from TB. We are now moving a new candidate vaccine, DAR-901, through early phase clinical trials.

Clinical ethics. I chair the Clinical Ethics Committee at Dartmouth-Hitchcock Medical Center, which seeks to provide clinical consultation, education and policy support for clinicians, patients and families.

Rotations and Thesis Projects:

Thesis project: "Semen Protects CD4+ T cells from HIV infection," Emmanuel Balandya, MD, Fogarty Fellow, PhD 2012 --> post-doc at Harvard Medical School --> faculty at Muhimbili University of Health and Allied Sciences

Grant Information:

1. PI, Mentored Clinical Scientist Development Award 1K08AI069915-01, "Mechanisms of Regulatory T cell Mediated Suppression of HIV-specific Cellular Immunity," 2006-2011

2. Subproject director, NCRR Centers of Biomedical Research Excellence, 5P20RR016437-08, "Center for Molecular, Cellular, and Translational Immunological Research," 2009-2012

3. PI, Hitchcock Foundation Henry Heyl Award, 2005

4. PI, Infectious Diseases Society of America ERF/NFID Astellas Young Investigator Award, 2007

5. Co-PI, Strategy 4 grant for Translational HIV/TB Research Specimen Repository

6. PI, Hitchcock Foundation Research Grant 2010 "Semen protects CD4+ T cells from HIV infection"

7. PI, Campbell Foundation grant 2010 "Semen protects CD4+ T cells from HIV infection"

8. Co-PI, SYNERGY CTSA grant on ethnography of study subject attitudes regarding participation in a TB vaccine trial with anthropologist Sienna Craig, PhD, 2015

Courses Taught:

Medical students:
Scientific Basis of Medicine, 14 courses in the second year of medical school, co-director

Scientific Basis of Medicine - Infectious Diseases, course director

Advanced Medical Sciences, course director

Infectious Diseases Elective, elective director
Single sessions in multiple courses

Undergraduates:
HIV through a Biosocial Lens: 30 Years of a Modern Plague, co-course director with anthropologist Sienna Craig, PhD

Rites of Passage: The Biology and Culture of Life's Transitions, co-course director with anthropologist Sienna Craig, PhD

Biography:

Tim Lahey is an HIV and infectious diseases physician, an educator, a clinical ethicist, and an investigator with a focus on HIV transmission and tuberculosis vaccines.

Tim studied at Georgetown University, Duke University School of Medicine, and Harvard Medical School. He completed clinical and research training at LDS Hospital and the University of Utah, Beth Israel Deaconess Medical Center, and the Massachusetts General Hospital including the Partners AIDS Research Center.

Tim is Director of Education at The Dartmouth Institute for Health Policy & Clinical Practice. At Dartmouth's Geisel School of Medicine, Tim is co-director of the 14-course cycle of courses in the second year of medical school called, "The Scientific Basis of Medicine." Tim also directs the second year course SBM Infectious Diseases, the fourth year course Advanced Medical Sciences, he helped found and co-directed the Health & Values medical school theme from 2011-2017, and he runs the Clinical Infectious Diseases Elective. He is faculty advisor of the Geisel chapter of the Albert Schweitzer Fellowship and was the 2015-2016 chair of the Geisel Academy of Master Educators.

Tim's teaching honors include the Clinical Science Teaching Award in 2010, Distinguished Lecturer 2011, Almy Professor's Award for Excellence in Teaching 2011, Gold Humanism Scholar 2012, and student body election as graduation farewell speaker every year from 2009 to 2017.


Selected Publications:

 

Altruism, Scepticism, and collective decision-making in foreign-born U.S. residents in a tuberculosis vaccine trial.
Craig SR, Lahey T, Dixit A, Fordham von Reyn C
BMC Public Health. 2018 Apr 23;18(1):535. doi: 10.1186/s12889-018-5460-3. Epub 2018 Apr 23.
PMID: 29685114

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site.
Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Karlsson Hedestam GB, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman ME
JCI Insight. 2018 Mar 8;3(5) pii: 97018. doi: 10.1172/jci.insight.97018. Epub 2018 Mar 8.
PMID: 29515029

A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa.
Sobota RS, Stein CM, Kodaman N, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Matee M, Mayanja-Kizza H, Joloba M, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Williams SM, Sirugo G
PLoS Genet. 2017 Jun;13(6):e1006710. doi: 10.1371/journal.pgen.1006710. Epub 2017 Jun 19.
PMID: 28628665

Safety and immunogenicity of an inactivated whole cell tuberculosis vaccine booster in adults primed with BCG: A randomized, controlled trial of DAR-901.
von Reyn CF, Lahey T, Arbeit RD, Landry B, Kailani L, Adams LV, Haynes BC, Mackenzie T, Wieland-Alter W, Connor RI, Tvaroha S, Hokey DA, Ginsberg AM, Waddell R
PLoS One. 2017;12(5):e0175215. doi: 10.1371/journal.pone.0175215. Epub 2017 May 12.
PMID: 28498853

Immunogenicity and Protective Efficacy of the DAR-901 Booster Vaccine in a Murine Model of Tuberculosis.
Lahey T, Laddy D, Hill K, Schaeffer J, Hogg A, Keeble J, Dagg B, Ho MM, Arbeit RD, von Reyn CF
PLoS One. 2016;11(12):e0168521. doi: 10.1371/journal.pone.0168521. Epub 2016 Dec 20.
PMID: 27997597

Principles of Ethical Leadership Illustrated by Institutional Management of Prion Contamination of Neurosurgical Instruments.
Lahey T, Pepe J, Nelson W
Camb Q Healthc Ethics. 2017 Jan;26(1):173-179.
PMID: 27934578

Mycobacterium bovis BCG and New Vaccines for the Prevention of Tuberculosis.
Lahey T, von Reyn CF
Microbiol Spectr. 2016 Oct;4(5) doi: 10.1128/microbiolspec.TNMI7-0003-2016.
PMID: 27763257

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.
Sobota RS, Stein CM, Kodaman N, Scheinfeldt LB, Maro I, Wieland-Alter W, Igo RP Jr, Magohe A, Malone LL, Chervenak K, Hall NB, Modongo C, Zetola N, Matee M, Joloba M, Froment A, Nyambo TB, Moore JH, Scott WK, Lahey T, Boom WH, von Reyn CF, Tishkoff SA, Sirugo G, Williams SM
Am J Hum Genet. 2016 Mar 3;98(3):514-524. doi: 10.1016/j.ajhg.2016.01.015.
PMID: 26942285

Ethical Issues in Pediatric Global Health.
Adams L, Suresh GK, Lahey T
Pediatr Clin North Am. 2016 Feb;63(1):195-208. doi: 10.1016/j.pcl.2015.09.002.
PMID: 26613697

A proposed nationwide reporting system to satisfy the ethical obligation to prevent drug diversion-related transmission of hepatitis C in healthcare facilities.
Lahey T, Nelson WA
Clin Infect Dis. 2015 Jun 15;60(12):1816-20. doi: 10.1093/cid/civ203. Epub 2015 Mar 12.
PMID: 25767254