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Brent L Berwin, PhD

Title(s):
Associate Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
University of Wisconsin-Madison, Ph.D., 1999
Lewis & Clark College, B.S., 1991

Dr. Berwin graduated from the University of Wisconsin-Madison in 1999. He did his postdoc training at Duke University and joined Dartmouth Medical School in the fall of 2004. Dr. Berwin is an Associate Professor in the Department of Microbiology and Immunology.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~immuno-cobre/

Contact Information:

Dartmouth Medical Center
1 Medical Center Dr.
HB 7556 - Rm. 614W
Lebanon NH 03756

Phone: 603-650-6899
Fax: 603-650-6223
Email: berwin@dartmouth.edu


Selected Publications:

 

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.
Barnaby R, Koeppen K, Nymon A, Hampton TH, Berwin B, Ashare A, Stanton B
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 16;:ajplung004612017. doi: 10.1152/ajplung.00461.2017. Epub 2017 Nov 16.
PMID: 29146575

The effect of loss of O-antigen ligase on phagocytic susceptibility of motile and non-motile Pseudomonas aeruginosa.
Demirdjian S, Schutz K, Wargo MJ, Lam JS, Berwin B
Mol Immunol. 2017 Dec;92:106-115. doi: 10.1016/j.molimm.2017.10.015. Epub 2017 Oct 20.
PMID: 29059582

Acidosis Exacerbates in vivo IL-1-Dependent Inflammatory Responses and Neutrophil Recruitment During Pulmonary Pseudomonas aeruginosa Infection.
Torres IM, Patankar YR, Berwin BL
Am J Physiol Lung Cell Mol Physiol. 2017 Oct 5;:ajplung003382017. doi: 10.1152/ajplung.00338.2017. Epub 2017 Oct 5.
PMID: 28982735

Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
Martinez EM, Young AL, Patankar YR, Berwin BL, Wang L, von Herrmann KM, Weier JM, Havrda MC
Toxicol Sci. 2017 Sep 1;159(1):64-75. doi: 10.1093/toxsci/kfx117.
PMID: 28903492

Acidosis increases the susceptibility of respiratory epithelial cells to <i>Pseudomonas aeruginosa</i>-induced cytotoxicity.
Torres IM, Demirdjian S, Vargas J, Goodale BC, Berwin B
Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L126-L137. doi: 10.1152/ajplung.00524.2016. Epub 2017 Apr 6.
PMID: 28385813

Blood clot detection using magnetic nanoparticles.
Khurshid H, Friedman B, Berwin B, Shi Y, Ness DB, Weaver JB
AIP Adv. 2017 May;7(5):056723. doi: 10.1063/1.4977073. Epub 2017 Feb 16.
PMID: 28289550

Monomethylarsonous Acid (MMAIII) Has an Adverse Effect on the Innate Immune Response of Human Bronchial Epithelial Cells to Pseudomonas aeruginosa.
Notch EG, Goodale BC, Barnaby R, Coutermarsh B, Berwin B, Taylor VF, Jackson BP, Stanton BA
PLoS One. 2015;10(11):e0142392. doi: 10.1371/journal.pone.0142392. Epub 2015 Nov 10.
PMID: 26554712

Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa.
Patankar YR, Mabaera R, Berwin B
Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L902-13. doi: 10.1152/ajplung.00228.2015. Epub 2015 Aug 21.
PMID: 26472815

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Mol Ther Methods Clin Dev. 2015;2:15021. doi: 10.1038/mtm.2015.21. Epub 2015 Jun 17.
PMID: 26151066

Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.
Shepardson KM, Jhingran A, Caffrey A, Obar JJ, Suratt BT, Berwin BL, Hohl TM, Cramer RA
PLoS Pathog. 2014 Sep;10(9):e1004378. doi: 10.1371/journal.ppat.1004378. Epub 2014 Sep 25.
PMID: 25255025