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Patricia A. Pioli, PhD

Title(s):
Assistant Professor of Microbiology and Immunology
Assistant Professor of Obstetrics and Gynecology

Department(s):
Microbiology and Immunology
Obstetrics and Gynecology

Education:
Dartmouth Medical School, Ph.D. 2001
George Washington University, B.S. 1993

Programs:
Immunology Program
Program in Experimental and Molecular Medicine

Contact Information:

Dartmouth Medical School
HB 7420
Lebanon NH 03756

Office: 734W Borwell Building
Phone: 603-650-2584
Fax: 603-650-6130
Email: pioli@dartmouth.edu


Professional Interests:

autoimmunity, cancer immunotherapy, molecular immunology, endocrinology

Rotations and Thesis Projects:

1. Determine how aberrant regulation of miRNAs affects activation of macrophages in autoimmune systemic sclerosis (scleroderma)

2. Identify the role that macrophages play in the immune/fibrotic axis in scleroderma

3. Determine how modulation of the tumor immune landscape (microenvironment) can be used to combat cancer

Biography:

Dr. Pioli received a B.S. in biology from George Washington University in 1993 and a Ph.D. in biochemistry from Dartmouth Medical School in 2001. She performed post-doctoral research with Dr. Paul Guyre at Dartmouth from 2001-2004, studying the mechanisms by which cortisol influences macrophage activation and immune function. She was appointed Research Assistant Professor of Physiology from 2004-2010. In July 2010, Dr. Pioli joined the faculty of Dartmouth Medical School as Assistant Professor in the Department of Obstetrics and Gynecology and Microbiology and Immunology.


Selected Publications:

 

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML
Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1. Epub 2017 Mar 23.
PMID: 28330499

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412

The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Leal AS, Sporn MB, Pioli PA, Liby KT
Carcinogenesis. 2016 Dec;37(12):1170-1179. Epub 2016 Sep 22.
PMID: 27659181

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
Ball MS, Shipman EP, Kim H, Liby KT, Pioli PA
PLoS One. 2016;11(2):e0149600. doi: 10.1371/journal.pone.0149600. Epub 2016 Feb 26.
PMID: 26918785

Glucocorticoids enhance the in vivo migratory response of human monocytes.
Yeager MP, Pioli PA, Collins J, Barr F, Metzler S, Sites BD, Guyre PM
Brain Behav Immun. 2016 May;54:86-94. doi: 10.1016/j.bbi.2016.01.004. Epub 2016 Jan 11.
PMID: 26790757

Gene expression profiling offers insights into the role of innate immune signaling in SSc.
Johnson ME, Pioli PA, Whitfield ML
Semin Immunopathol. 2015 Sep;37(5):501-9. doi: 10.1007/s00281-015-0512-6. Epub 2015 Jul 30.
PMID: 26223504

Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.
Mahoney JM, Taroni J, Martyanov V, Wood TA, Greene CS, Pioli PA, Hinchcliff ME, Whitfield ML
PLoS Comput Biol. 2015 Jan;11(1):e1004005. doi: 10.1371/journal.pcbi.1004005. Epub 2015 Jan 8.
PMID: 25569146

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT
Carcinogenesis. 2013 Jan;34(1):199-210. doi: 10.1093/carcin/bgs319. Epub 2012 Oct 6.
PMID: 23042302

A subset of human uterine endometrial macrophages is alternatively activated.
Jensen AL, Collins J, Shipman EP, Wira CR, Guyre PM, Pioli PA
Am J Reprod Immunol. 2012 Nov;68(5):374-86. doi: 10.1111/j.1600-0897.2012.01181.x. Epub 2012 Aug 6.
PMID: 22882270

Cortisol exerts bi-phasic regulation of inflammation in humans.
Yeager MP, Pioli PA, Guyre PM
Dose Response. 2011;9(3):332-47. doi: 10.2203/dose-response.10-013.Yeager. Epub 2010 Aug 12.
PMID: 22013396