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Paul D. Manganiello, MD

Active Emeritus Professor of Obstetrics and Gynecology

Obstetrics and Gynecology

Jefferson Medical College, MD 1973
Seton Hall University, BA 1969

Contact Information:

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Phone: (603)-653-9240
Fax: (603) 650-0905
Email: paul.d.manganiello@hitchcock.org

Professional Interests:

Reproductive Endocrinology and Infertility

Grant Information:

1. Tubal Sterilization (Co-PI)
Date: January 1990-May 1992
Project Budget: $59,000.00 (co.-investigator)
Sponsor: Pfizer Hospital Products Group Research & Development

2. Multi-Center Osteoporosis Study: A Clinical Drug Trial Continuous Hormones as Replacement Therapy (CHART study). (PI-Clinical site)
Date: October 1989-December 1992
Project Budget: $175,000.00
Sponsor: Parke-Davis Pharmaceuticals

3. Gynecologic Applications of Photodynamic Therapy (PDT) (Co-PI)
Date: January 1994- June 1995
Project Budget: $6,500.00
Sponsor: Hitchcock Foundation

4. Multi-Center HRT Clinical Trial: Women’s Health, Osteoporosis, Progestin, Estrogen (HOPE study) (PI-Clinical site)
Date: September 1995- 1998
Project Budget: $319,000.00
Sponsor: Wyeth-Ayerst Pharmaceuticals

5. Tubal Sterilization: (Co-PI)
Date: June 1996-June 1997
Project Budget: $5,000.00
Sponsor: Department of Obstetrics and Gynecology DHMC

6. Regulation of Mucosal Immunity in the Human Female
Reproductive Tract, National Institute of Health. Immunology Program
Project # 5-901-A1- 34478: PI - Dr. C. Wira, Ph.D., Professor of Physiology, Dartmouth Medical School. Project Budget: $4,025,348.00 Medical Director (3%)

7. Multi-center HRT Clinical Trial: (Trimegestone Study) (PI-Clinical site)
Date: 1998- 2001
Project Budget: $209,000.00
Sponsor: Wyeth-Ayerst

8. Multi-center: Surgical Treatments Outcome Project: Dysfunctional Uterine Bleeding (STOP:DUB) (PI-clinical site)
Date: 1998- 2001
Project Budget $40,000
Sponsor: American College of Obstetricians and Gynecologists

9. Fibromyalgia Study: Low Dose Testosterone Therapy. Co-investgator (PI-Hillary White Ph.D.)
Date: 2001- 2002
Project Budget: $72,069
Sponsor: Bentley Pharmaceuticals

10. A Study of Lasofoxifene for the Treatment of Sexual Dysfunction (Hypoactive Desire) in Postmenopausal Women. (PI-Clinical site)
Date: 2001-2003
Project Budget: $74,000
Sponsor: Pfizer

11. A Study of Lasofoxifene for the Treatment of Sexual Dysfunction (Arousal Disorder) in Postmenopausal Women. (PI-Clinical site)
Date: 2001-2003
Project Budget: $74,000
Sponsor: Pfizer

12. Raloxifene Alendronate Comparison in Postmenopausal Women with Osteoporosis. (PI-Clinical site)
Date: 2001- 2004
Project Budget: $339,144
Sponsor: Lilly

13. A Study of Lasofoxifene for the Treatment of Vaginal Atrophy in Postmenopausal Women. (PI-Clinical site)
Date: 2001-2003
Project Budget: $83,620
Sponsor: Pfizer

14. A Novel Technique for Female Sterilization. Interventional Female Sterilization Using a Microwave Catheter. Co-PI
Date: 2002-2004
Project budget: $24,200
Sponsor: (Cardiovascular and Interventional Radiology Research and Education Foundation CIRREF)

15 A Phase III Study of the Efficacy and Safety of Lasofoxifene in the Treatment of
Vaginal Atrophy in Postmenopausal Women. (PI-Clinical site)
Date 2003-2004
Project Budget $39,689
Sponsor Pfizer

16 A Multicenter, Randomized, Double Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Administered Intravenously or Subcutaneously (via a Portable Infusion Pump) Compared to Oral treatment with Clomiphene Citrate in Anovulatory or Oligo-ovulatory Infertile Females.
Date: 2004-2005
Project Budget: $56,000.00
Sponsor: Ferring

17. A Double Blind Randomized, Placebo and Active Controlled Efficacy and Safety Study of Bazedoxifine / Conjugated Estrogens Combinations for the Treatment of Moderate to Severe Vulvar / Vaginal Atrophy in Postmenopausal Women
Date 2006- 2007
Project Budget $59,906.00
Sponsor Wyeth

18. A Phase 2b Multicenter, Double- Blind, Placebo-controlled, Parallel-Group, Dose Ranging Study Evaluating the Efficacy and Safety of PD-0299685 for the Treatment of Moderate to Severe Vasomotor Symptoms Associated with Menopause
Project Budget
Sponsor: Pfizer

19. The Birth Control Pill (extended cycle, ascending EE) is being studied for improvement in bleeding patterns and side effects.
Date: 2007-
Project Budget $
Sponsor: Duramed Research.

*International Patent Application #PCT/US98/16227 System and Method for Fallopian Tube Occlusion Ref.: 4503/007 PCT 2002

Courses Taught:

Dartmouth College:
1988-1994 Religion 11 Introduction to Religion and Morality
Course Director - Ron Green, Ph.D.
Topic: Reproductive Ethics

2002-2004 Nathan Smith Shadow Program
Course Director – Lee Witters, MD

Dartmouth Medical School Year I:
1986-1994 Department of Community and Family Medicine
Course Director - Dr. Allen Dietrich

1994-present Longitudinal Clinical Experience
Course Director - Dr. Nancy Cochran

Dartmouth Medical School Year II:
1980-present Scientific Basis of Medicine (SBM)
Course Director - Dr. Judy Stern
Topics presented: Infertility, Puberty, Amenorrhea Syndromes, Dysfunctional Uterine Bleeding, Menopause, Contraception, and Ethical Issues surrounding Abortion

2005- Co-course director Scientific Basis of Medicine Reproduction

Dartmouth Medical School Year III:
1979-present OB/GYN continuing 8 wk Clinical rotation
Course Director - Dr. Hanissian, Dr. William Young
Topic: Clinical Faculty

Dartmouth Medical School Year IV:
1979-2002 OB/GYN continuing 4wk Clinical rotation
Course Director - Dr. Young
Topic: Clinical Faculty

1984-present Reproductive Endocrinology and Infertility Elective: 4 wk.

Selected Publications:


  • Serum progesterone, 17 alpha-hydroxyprogesterone, human chorionic gonadotropin, and prolactin in early pregnancy and a case of spontaneous abortion. Fertil Steril 1981;36(1).

  • A ten-year prospective study of women with a history of recurrent fetal losses fails to identify Listeria Monocytogenes in the genital tract. Fertil Steril 1991;56(4).

  • . A Comparison of Clomiphene Citrate and Human Menopausal Gonadotrophin for use in conjunction with Intrauterine Inseminations. Fertil Steril 1997;68(3):405-12.

  • A Bipolar Radiofrequency Catheter Fails to Occlude a feline Uterine Horn: A Model for Fallopian Tube Occlusion. J. American Assoc. of Gynecologic Laparoscopists 5 (3):269-73 August 1998.

  • Comparison of the Vabra Aspirator and the Pipelle Endometrial Suction Catheter in Obtaining Adequate Tissue Samples. Journal of Reproductive Medicine 1998;43:889-892. Journal of Reproductive Medicine 1998;43:889-892.