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Steven N. Fiering, PhD

Title(s):
Professor of Microbiology and Immunology
Professor of Genetics

Department(s):
Microbiology and Immunology
Genetics

Education:
Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU


Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course


Selected Publications:

 

Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression.
Patel R, Czapar AE, Fiering S, Oleinick NL, Steinmetz NF
ACS Omega. 2018 Apr 30;3(4):3702-3707. doi: 10.1021/acsomega.8b00227. Epub 2018 Apr 2.
PMID: 29732445

In situ vaccination: Harvesting low hanging fruit on the cancer immunotherapy tree.
Sheen MR, Fiering S
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Apr 18;:e1524. doi: 10.1002/wnan.1524. Epub 2018 Apr 18.
PMID: 29667346

Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation.
Hoopes PJ, Wagner RJ, Duval K, Kang K, Gladstone DJ, Moodie KL, Crary-Burney M, Ariaspulido H, Veliz FA, Steinmetz NF, Fiering SN
Mol Pharm. 2018 Apr 12; doi: 10.1021/acs.molpharmaceut.8b00126. Epub 2018 Apr 12.
PMID: 29613803

Comparative aspects of canine and human inflammatory breast cancer.
Raposo TP, Arias-Pulido H, Chaher N, Fiering SN, Argyle DJ, Prada J, Pires I, Queiroga FL
Semin Oncol. 2017 Aug;44(4):288-300. doi: 10.1053/j.seminoncol.2017.10.012. Epub 2018 Jan 19.
PMID: 29526258

Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer.
Hoopes PJ, Mazur CM, Osterberg B, Song A, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Fiering SN
Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb;10066 pii: 100660G. doi: 10.1117/12.2256062. Epub 2017 Feb 20.
PMID: 29203952

Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer.
Hoopes PJ, Moodie KL, Petryk AA, Petryk JD, Sechrist S, Gladstone DJ, Steinmetz NF, Veliz FA, Bursey AA, Wagner RJ, Rajan A, Dugat D, Crary-Burney M, Fiering SN
Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb;10066 pii: 1006605. doi: 10.1117/12.2256213. Epub 2017 Feb 22.
PMID: 29203951

Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.
Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A
J Control Release. 2018 Jan 10;269:364-373. doi: 10.1016/j.jconrel.2017.11.021. Epub 2017 Nov 13.
PMID: 29146246

Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response.
Lee KL, Murray AA, Le DHT, Sheen MR, Shukla S, Commandeur U, Fiering S, Steinmetz NF
Nano Lett. 2017 Jul 12;17(7):4019-4028. doi: 10.1021/acs.nanolett.7b00107. Epub 2017 Jun 26.
PMID: 28650644

Cancer immunotherapy: Making allies of phagocytes.
Fiering S
Nat Nanotechnol. 2017 Jul;12(7):615-616. doi: 10.1038/nnano.2017.89. Epub 2017 Apr 24.
PMID: 28436962

Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke.
Payne P, Fiering S, Leiter JC, Zava DT, Crane-Godreau MA
Front Hum Neurosci. 2017;11:67. doi: 10.3389/fnhum.2017.00067. Epub 2017 Feb 21.
PMID: 28270757