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William B. Kinlaw III, MD

Contact Information

Professional Interests

Research Area:
Tumor Metabolism

Our research seeks to understand the peculiar metabolic needs of tumors, and how they adjust to them, with an eye toward exploiting tumor metabolism in the clinic. We have recently focused on the “addiction” of tumors, including breast cancers, to a supply of fatty acids. This has led to insights related to the regulation of lipid synthesis in tumors, and the ability to target it in preclinical systems and clinical trials. We recently found that tumors may not only synthesize fatty acids, but may also take them up from diet-derived lipoprotein particles in the circulation. Our laboratory has developed unique reagents to study these pathways, including novel antibodies and genetically engineered mice. We have also consistently focused on studies aimed to establish the relevance of our findings to actual human tumors, including breast and prostate cancers, sarcomas, and lymphomas, and are involved in clinical trials of the use of unusual fatty acids to manipulate these pathways inpatients.

Rotations and Thesis Projects

Rotations and Thesis Projects:
1. Determine the impact of the loss of cell-cell adhesion on metabolism of breast cancer cells.
2. Define the role of lipoprotein lipase to breast cancer metastasis in genetically engineered mice.
3. Determine the relevance of lipid uptake vs. synthesis pathways in a large (960 cases) array of human breast cancer tissue samples.

Grant Information

Role of protein S14 in normal and neoplastic mammary (NIH/NCI)
Endocrinology Training Grant (NIH)

Courses Taught

Endocrinology (Course Director)

Biography

Dr. Kinlaw received his MD from Tufts University in Boston in 1977 and trained under Dr. Jack Oppenheimer in Minneapolis until 1990, when he joined the faculty at Dartmouth.