Selected Publications
Gan T*, Jude CD*, Zaffuto K and P Ernst. Developmentally-induced MLL loss reveals defects in postnatal hematopoiesis Leukemia, Oct 24(10):1732-41, 2010 (*equal contribution)
Thiel A, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, and X Hua. MLL-AF9-induced leukemogenesis requires co-expression of the wild type Mll allele. Cancer Cell, 17(3);148-159 2010
Passegue, E and P Ernst. IFN-alpha wakes up sleeping hematopoietic stem cells. Nature Medicine 15(6):612-613, 2009
Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll is essential for neurogenesis from postnatal neural stem cells. Nature, 458:529-533, 2009
Jude CD*, Gaudet JJ*, Speck NA and P Ernst. Leukemia and Hematopoietic Stem Cells: Balancing Proliferation and Quiescence. Cell Cycle, 7 (5); 586-591, 2008
*equal contribution
Jude CD, Climer L, Xu D, Artinger E, Fisher JK, and P Ernst. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3); 324-337, 2007
Bansal D, Fröhling S, Scholl C, Mcdowell E, Lee BH, Döhner K, Ernst P, Zon LI, Gilliland DG, and BJP Huntly. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone, and in cooperation with Meis1a, in a murine model. PNAS 109(45):16924-16969, 2006
Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. PNAS 2005 102(52):19081-6.
Wang J, Iwasaki H, Kristov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA Akashi K and SJ Korsmeyer. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 24(2):361-381, 2005.
Ernst P, Mabon M, Davidson AJ, Zon LI, and Korsmeyer SJ. An Mll-dependent Hox Program Drives Hematopoietic Progenitor Expansion. Current Biology 14(22):2063-2069, 2004.
Ernst P, Fisher J, Avery W, Wade S, Foy D, and Korsmeyer SJ. Definitive Hematopoiesis Requires the Mixed Lineage Leukemia Gene. Dev Cell 6(3):437-443, 2004.
Davidson A, Ernst P, Wang Y, Dekens MPS, Kinglsey PD, Palis J, Korsmeyer SJ, Daley G and Zon LI. Cdx4 mutants fail to specify haematopoietic progenitors during embryogenesis and can be rescued by multiple Hox genes. Nature 425:300-306, 2003.
Hsieh J, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 23:186-194, 2003.
Ernst P, Wang, J, and Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol 9:282-287, 2002.
Ernst P, Wang J, Huang M, Goodman RH, and Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol 21:2249-2258, 2001.
Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuisen M, Berns A, van der Lugt NMT, Shashikant CS, Ruddle F H, Seto M and Korsmeyer SJ. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A. 96:14372-14377, 1999.
Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW and Smale ST. A potential role for Elf-1 in terminal transferase gene regulation. Mol Cell Biol 16:6121-6131, 1996.
Ernst P and Smale ST. Combinatorial regulation of transcription II: the immunoglobulin µ heavy chain gene. Immunity 2:427-438, 1995.
Ernst P and Smale ST. Combinatorial regulation of transcription I: general aspects of transcriptional control. Immunity 2:311-319, 1995.
Hahm K, Ernst P, Lo K, Kim G, Turck C and Smale S. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol Cell Biol 114:7111-7123, 1994.
Ernst P, Hahm K and Smale ST. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol Cell Biol 13:2982-2992, 1993.