Selected Publications
Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis. Cell Reports May 7, 2014. [epub ahead of print]
Artinger EL and P Ernst. Cell context in the control of self-renewal and proliferation regulated by MLL1. Cell Cycle. 2013 Sep 15;12(18):2969-72.
Li BE, Gan T, Meyerson M, Rabbitts T and P Ernst. Distinct pathways regulated by Menin and by MLL1 in hematopoietic stem cells and B-cells. Blood. 2013 Sep 19;122(12):2039-46.
Huang LH, Gui J, Artinger EL, Craig R, Berwin BL, Ernst P, Chang CC, and Chang TY. Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis. Arterioscler Thromb and Vasc Biol, Jul 11, 2013 [epub ahead of print]
Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EKY, Moore AW, Chen Y, Cheng C and P Ernst. An MLL-dependent program sustains hematopoiesis. Proc Natl Acad Sci USA, 2013 Jul 16;110(29):12000-5.
Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carrière C. The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition Dev Cell. 2012 Dec 11;23(6):1203-18.
Ernst, P and CR Vakoc. WRAD: enabler of the SET1-family of methyltransferases. Brief Funct Genome. 2012 May;11(3):217-26.
Gan T*, Jude CD*, Zaffuto K and P Ernst. Developmentally-induced MLL loss reveals defects in postnatal hematopoiesis Leukemia, Oct 24(10):1732-41, 2010 (*equal contribution)
Thiel A, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, and X Hua. MLL-AF9-induced leukemogenesis requires co-expression of the wild type Mll allele. Cancer Cell, 17(3);148-159 2010
Passegue, E and P Ernst. IFN-alpha wakes up sleeping hematopoietic stem cells. Nature Medicine 15(6):612-613, 2009
Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll is essential for neurogenesis from postnatal neural stem cells. Nature, 458:529-533, 2009
Jude CD*, Gaudet JJ*, Speck NA and P Ernst. Leukemia and Hematopoietic Stem Cells: Balancing Proliferation and Quiescence. Cell Cycle, 7 (5); 586-591, 2008
*equal contribution
Jude CD, Climer L, Xu D, Artinger E, Fisher JK, and P Ernst. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3); 324-337, 2007
Bansal D, Fröhling S, Scholl C, Mcdowell E, Lee BH, Döhner K, Ernst P, Zon LI, Gilliland DG, and BJP Huntly. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone, and in cooperation with Meis1a, in a murine model. PNAS 109(45):16924-16969, 2006
Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. PNAS 2005 102(52):19081-6.
Wang J, Iwasaki H, Kristov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA Akashi K and SJ Korsmeyer. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 24(2):361-381, 2005.
Ernst P, Mabon M, Davidson AJ, Zon LI, and Korsmeyer SJ. An Mll-dependent Hox Program Drives Hematopoietic Progenitor Expansion. Current Biology 14(22):2063-2069, 2004.
Ernst P, Fisher J, Avery W, Wade S, Foy D, and Korsmeyer SJ. Definitive Hematopoiesis Requires the Mixed Lineage Leukemia Gene. Dev Cell 6(3):437-443, 2004.
Davidson A, Ernst P, Wang Y, Dekens MPS, Kinglsey PD, Palis J, Korsmeyer SJ, Daley G and Zon LI. Cdx4 mutants fail to specify haematopoietic progenitors during embryogenesis and can be rescued by multiple Hox genes. Nature 425:300-306, 2003.
Hsieh J, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol 23:186-194, 2003.
Ernst P, Wang, J, and Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol 9:282-287, 2002.
Ernst P, Wang J, Huang M, Goodman RH, and Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol 21:2249-2258, 2001.
Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuisen M, Berns A, van der Lugt NMT, Shashikant CS, Ruddle F H, Seto M and Korsmeyer SJ. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A. 96:14372-14377, 1999.