Publications
Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis.
Lone MA, Atkinson AE, Hodge CA, Cottier S, Martinez-Montañes F, Maithel S, Mene-Saffrane L, Cole CN, Schneiter R
Eukaryot Cell. 2015 Dec;14(12):1217-27. doi: 10.1128/EC.00101-15. Epub 2015 Oct 2.
PMID: 26432634
Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.
Estruch F, Hodge C, Gomez-Navarro N, Peiro-Chova L, Heath CV, Cole CN
BMC Genet. 2012 Sep 10;13:80. doi: 10.1186/1471-2156-13-80. Epub 2012 Sep 10.
PMID: 22963203
Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.
Folkmann AW, Noble KN, Cole CN, Wente SR
Nucleus. 2011 Nov-Dec;2(6):540-8. doi: 10.4161/nucl.2.6.17881. Epub 2011 Nov 1.
PMID: 22064466
The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1.
Noble KN, Tran EJ, Alcazar-Roman AR, Hodge CA, Cole CN, Wente SR
Genes Dev. 2011 May 15;25(10):1065-77. doi: 10.1101/gad.2040611.
PMID: 21576266
The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.
Hodge CA, Tran EJ, Noble KN, Alcazar-Roman AR, Ben-Yishay R, Scarcelli JJ, Folkmann AW, Shav-Tal Y, Wente SR, Cole CN
Genes Dev. 2011 May 15;25(10):1052-64. doi: 10.1101/gad.2041611.
PMID: 21576265
Integrating complex functions: coordination of nuclear pore complex assembly and membrane expansion of the nuclear envelope requires a family of integral membrane proteins.
Schneiter R, Cole CN
Nucleus. 2010 Sep-Oct;1(5):387-92. doi: 10.4161/nucl.1.5.12333.
PMID: 21326820
Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum.
Hodge CA, Choudhary V, Wolyniak MJ, Scarcelli JJ, Schneiter R, Cole CN
J Cell Sci. 2010 Jan 1;123(Pt 1):141-51. doi: 10.1242/jcs.055046.
PMID: 20016074
Uncovering growth-suppressive MicroRNAs in lung cancer.
Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E
Clin Cancer Res. 2009 Feb 15;15(4):1177-83. doi: 10.1158/1078-0432.CCR-08-1355.
PMID: 19228723
A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.
Estruch F, Peiro-Chova L, Gomez-Navarro N, Durban J, Hodge C, Del Olmo M, Cole CN
Mol Genet Genomics. 2009 Jan;281(1):125-34. doi: 10.1007/s00438-008-0402-x. Epub 2008 Nov 26.
PMID: 19034519
Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P-body components.
Scarcelli JJ, Viggiano S, Hodge CA, Heath CV, Amberg DC, Cole CN
Genetics. 2008 Aug;179(4):1945-55. doi: 10.1534/genetics.108.091256. Epub 2008 Aug 9.
PMID: 18689878
Harnessing genomics to explore the processes and evolution of mRNA export.
Wolyniak MJ, Cole CN
RNA Biol. 2008 Apr-Jun;5(2):68-72. Epub 2008 May 9.
PMID: 18483471
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.
Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S, Cole CN
Cancer Res. 2007 Dec 15;67(24):11612-20.
PMID: 18089790
The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes.
Scarcelli JJ, Hodge CA, Cole CN
J Cell Biol. 2007 Aug 27;178(5):799-812.
PMID: 17724120
The DEAD-box RNA helicase Dbp5 functions in translation termination.
Gross T, Siepmann A, Sturm D, Windgassen M, Scarcelli JJ, Seedorf M, Cole CN, Krebber H
Science. 2007 Feb 2;315(5812):646-9.
PMID: 17272721
Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.
Rollenhagen C, Hodge CA, Cole CN
Eukaryot Cell. 2007 Mar;6(3):505-13. Epub 2007 Jan 26.
PMID: 17259545
The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint.
Sempere LF, Cole CN, McPeek MA, Peterson KJ
J Exp Zool B Mol Dev Evol. 2006 Nov 15;306(6):575-88.
PMID: 16838302
Unravelling mRNA export.
Cole CN, Scarcelli JJ
Nat Cell Biol. 2006 Jul;8(7):645-7.
PMID: 16820771
Transport of messenger RNA from the nucleus to the cytoplasm.
Cole CN, Scarcelli JJ
Curr Opin Cell Biol. 2006 Jun;18(3):299-306. Epub 2006 May 8.
PMID: 16682182
Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Dunn EF, Hammell CM, Hodge CA, Cole CN
Genes Dev. 2005 Jan 1;19(1):90-103.
PMID: 15630021
Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export.
Estruch F, Hodge CA, Rodriguez-Navarro S, Cole CN
J Biol Chem. 2005 Mar 11;280(10):9691-7. Epub 2004 Dec 24.
PMID: 15619606
The nuclear pore complex and the DEAD box protein Rat8p/Dbp5p have nonessential features which appear to facilitate mRNA export following heat shock.
Rollenhagen C, Hodge CA, Cole CN
Mol Cell Biol. 2004 Jun;24(11):4869-79.
PMID: 15143180
Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.
Farago M, Nahari T, Hammel C, Cole CN, Choder M
Mol Biol Cell. 2003 Jul;14(7):2744-55.
PMID: 12857861
An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components.
Estruch F, Cole CN
Mol Biol Cell. 2003 Apr;14(4):1664-76.
PMID: 12686617
Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients.
Harris A, Migliardi R, Rechtman E, Cole CN, Yee AB, Garzozi HJ
Eur J Ophthalmol. 2003 Jan-Feb;13(1):24-31.
PMID: 12635671
Coupling of termination, 3' processing, and mRNA export.
Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN
Mol Cell Biol. 2002 Sep;22(18):6441-57.
PMID: 12192043
Analysis of RNA export.
Cole CN, Heath CV, Hodge CA, Hammell CM, Amberg DC
Methods Enzymol. 2002;351:568-87.
PMID: 12073369
Choreographing mRNA biogenesis.
Cole CN
Nat Genet. 2001 Sep;29(1):6-7.
PMID: 11528378
mRNA export: the long and winding road.
Cole CN
Nat Cell Biol. 2000 Apr;2(4):E55-8.
PMID: 10783248
Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.
Hodge CA, Colot HV, Stafford P, Cole CN
EMBO J. 1999 Oct 15;18(20):5778-88.
PMID: 10523319
Functional characterization of a Nup159p-containing nuclear pore subcomplex.
Belgareh N, Snay-Hodge C, Pasteau F, Dagher S, Cole CN, Doye V
Mol Biol Cell. 1998 Dec;9(12):3475-92.
PMID: 9843582
Nucleocytoplasmic transport: driving and directing transport.
Cole CN, Hammell CM
Curr Biol. 1998 May 21;8(11):R368-72.
PMID: 9635180
Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.
Snay-Hodge CA, Colot HV, Goldstein AL, Cole CN
EMBO J. 1998 May 1;17(9):2663-76.
PMID: 9564048
Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p.
Saavedra CA, Hammell CM, Heath CV, Cole CN
Genes Dev. 1997 Nov 1;11(21):2845-56.
PMID: 9353254
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z
J Biol Chem. 1997 Sep 19;272(38):23668-74.
PMID: 9295308
Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.
Conzen SD, Snay CA, Cole CN
J Virol. 1997 Jun;71(6):4536-43.
PMID: 9151847
Regulation of the export of RNA from the nucleus.
Cole CN, Saavedra C
Semin Cell Dev Biol. 1997 Feb;8(1):71-8.
PMID: 15001108
C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure.
Dockendorff TC, Heath CV, Goldstein AL, Snay CA, Cole CN
Mol Cell Biol. 1997 Feb;17(2):906-20.
PMID: 9001245
Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells.
Lu M, Conzen SD, Cole CN, Arrick BA
Cancer Res. 1996 Oct 15;56(20):4578-81.
PMID: 8840964
The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export.
Del Priore V, Snay CA, Bahr A, Cole CN
Mol Biol Cell. 1996 Oct;7(10):1601-21.
PMID: 8898365
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Anderson MM, Chen J, Cole CN, Conrad SE
J Virol. 1996 Sep;70(9):6304-13.
PMID: 8709258
Regulation of mRNA export in response to stress in Saccharomyces cerevisiae.
Saavedra C, Tung KS, Amberg DC, Hopper AK, Cole CN
Genes Dev. 1996 Jul 1;10(13):1608-20.
PMID: 8682292
Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.
Goldstein AL, Snay CA, Heath CV, Cole CN
Mol Biol Cell. 1996 Jun;7(6):917-34.
PMID: 8816998
The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts.
Conzen SD, Cole CN
Oncogene. 1995 Dec 7;11(11):2295-302.
PMID: 8570180
Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene.
Heath CV, Copeland CS, Amberg DC, Del Priore V, Snyder M, Cole CN
J Cell Biol. 1995 Dec;131(6 Pt 2):1677-97.
PMID: 8557737
Gas1-induced growth suppression requires a transactivation-independent p53 function.
Del Sal G, Ruaro EM, Utrera R, Cole CN, Levine AJ, Schneider C
Mol Cell Biol. 1995 Dec;15(12):7152-60.
PMID: 8524283
A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigens.
Casaz P, Rice PW, Cole CN, Hansen U
J Virol. 1995 Jun;69(6):3501-9.
PMID: 7745697
A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.
Gorsch LC, Dockendorff TC, Cole CN
J Cell Biol. 1995 May;129(4):939-55.
PMID: 7744966
Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.
Li O, Heath CV, Amberg DC, Dockendorff TC, Copeland CS, Snyder M, Cole CN
Mol Biol Cell. 1995 Apr;6(4):401-417.
PMID: 7626806
A novel translational regulation function for the simian virus 40 large-T antigen gene.
Rajan P, Swaminathan S, Zhu J, Cole CN, Barber G, Tevethia MJ, Thimmapaya B
J Virol. 1995 Feb;69(2):785-95.
PMID: 7815544
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.
Schlenstedt G, Saavedra C, Loeb JD, Cole CN, Silver PA
Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):225-9.
PMID: 7816822
The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
Quartin RS, Cole CN, Pipas JM, Levine AJ
J Virol. 1994 Mar;68(3):1334-41.
PMID: 8107198
Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen.
Rice PW, Cole CN
J Virol. 1993 Nov;67(11):6689-97.
PMID: 8411371
Nuclear PRP20 protein is required for mRNA export.
Amberg DC, Fleischmann M, Stagljar I, Cole CN, Aebi M
EMBO J. 1993 Jan;12(1):233-41.
PMID: 7679070
Adenovirus helper function activity of simian virus 40 T antigen mutants.
Heath CV, Fanning E, Cole CN
Virology. 1992 Aug;189(2):762-5.
PMID: 1641988
Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Amberg DC, Goldstein AL, Cole CN
Genes Dev. 1992 Jul;6(7):1173-89.
PMID: 1628825
Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.
Bentivoglio CM, Zhu J, Cole CN
J Virol. 1992 Jul;66(7):4209-19.
PMID: 1318402
Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.
Zhu J, Rice PW, Gorsch L, Abate M, Cole CN
J Virol. 1992 May;66(5):2780-91.
PMID: 1313902
The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.
Zhu JY, Abate M, Rice PW, Cole CN
J Virol. 1991 Dec;65(12):6872-80.
PMID: 1658380
Mapping the transcriptional transactivation function of simian virus 40 large T antigen.
Zhu JY, Rice PW, Chamberlain M, Cole CN
J Virol. 1991 Jun;65(6):2778-90.
PMID: 1851853
The growth of simian virus 40 (SV40) host range/adenovirus helper function mutants in an African green monkey cell line that constitutively expresses the SV40 agnoprotein.
Stacy TP, Chamberlain M, Carswell S, Cole CN
J Virol. 1990 Jul;64(7):3522-6.
PMID: 2161954
Spatial constraints on polyadenylation signal function.
Heath CV, Denome RM, Cole CN
J Biol Chem. 1990 Jun 5;265(16):9098-104.
PMID: 2160955
Simian virus 40 host range/helper function mutations cause multiple defects in viral late gene expression.
Stacy T, Chamberlain M, Cole CN
J Virol. 1989 Dec;63(12):5208-15.
PMID: 2555552
Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene.
Zhu JY, Cole CN
J Virol. 1989 Nov;63(11):4777-86.
PMID: 2552152
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.
Denome RM, Cole CN
Mol Cell Biol. 1988 Nov;8(11):4829-39.
PMID: 2463466
Biological properties of simian virus 40 host range mutants lacking the COOH-terminus of large T antigen.
Cole CN, Stacy TP
Virology. 1987 Nov;161(1):170-80.
PMID: 2823459
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA.
Zhang F, Cole CN
Mol Cell Biol. 1987 Sep;7(9):3277-86.
PMID: 2823124
Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.
Zhang F, Denome RM, Cole CN
Mol Cell Biol. 1986 Dec;6(12):4611-23.
PMID: 2879221
Absence of a structural basis for intracellular recognition and differential localization of nuclear and plasma membrane-associated forms of simian virus 40 large tumor antigen.
Jarvis DL, Cole CN, Butel JS
Mol Cell Biol. 1986 Mar;6(3):758-67.
PMID: 3022127
Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A.
Cole CN, Tornow J, Clark R, Tjian R
J Virol. 1986 Feb;57(2):539-46.
PMID: 3003386
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Cole CN, Stacy TP
Mol Cell Biol. 1985 Aug;5(8):2104-13.
PMID: 3018551
Two separable functional domains of simian virus 40 large T antigen: carboxyl-terminal region of simian virus 40 large T antigen is required for efficient capsid protein synthesis.
Tornow J, Polvino-Bodnar M, Santangelo G, Cole CN
J Virol. 1985 Feb;53(2):415-24.
PMID: 2982029
Intracistronic complementation in the simian virus 40 A gene.
Tornow J, Cole CN
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6312-6.
PMID: 6312452
Nonviable mutants of simian virus 40 with deletions near the 3' end of gene A define a function for large T antigen required after onset of viral DNA replication.
Tornow J, Cole CN
J Virol. 1983 Sep;47(3):487-94.
PMID: 6312080
Preparation of a "functional library" of African green monkey DNA fragments which substitute for the processing/polyadenylation signal in the herpes simplex virus type 1 thymidine kinase gene.
Santangelo GM, Cole CN
Mol Cell Biol. 1983 Apr;3(4):643-53.
PMID: 6304500
Analysis in Cos-1 cells of processing and polyadenylation signals by using derivatives of the herpes simplex virus type 1 thymidine kinase gene.
Cole CN, Santangelo GM
Mol Cell Biol. 1983 Feb;3(2):267-79.
PMID: 6300661
Construction and characterization of viable deletion mutants of simian virus 40 lacking sequences near the 3' end of the early region.
Polvino-Bodnar M, Cole CN
J Virol. 1982 Aug;43(2):489-502.
PMID: 6287029
Simian virus 40 mutants with deletions at the 3' end of the early region are defective in adenovirus helper function.
Cole CN, Crawford LV, Berg P
J Virol. 1979 Jun;30(3):683-91.
PMID: 225537
Organization and expression of early genes of simian virus 40.
Crawford LV, Cole CN, Smith AE, Paucha E, Tegtmeyer P, Rundell K, Berg P
Proc Natl Acad Sci U S A. 1978 Jan;75(1):117-21.
PMID: 203926
Physical and genetic characterization of deletion mutants of simian virus 40 constructed in vitro.
Cole CN, Landers T, Goff SP, Manteuil-Brutlag S, Berg P
J Virol. 1977 Oct;24(1):277-94.
PMID: 198579
A modified Tc-99m-phytate colloid for liver-spleen imaging.
Davis MA, Kaplan ML, Ahnberg DS, Cole CN
Int J Appl Radiat Isot. 1977 Jan-Feb;28(1-2):123-30.
PMID: 404259
An efficient radiopharmaceutical record-keeping system.
Cole CN
Hosp Formul. 1976 Jul;11(7):385, 388-9.
PMID: 1026697
Defective interfering (di) particles of poliovirus.
Cole CN
Prog Med Virol. 1975;20:180-207.
PMID: 172972
Defective interfering particles of poliovirus. IV. Mechanisms of enrichment.
Cole CN, Baltimore D
J Virol. 1973 Dec;12(6):1414-26.
PMID: 4357514
Defective interfering particles of poliovirus. 3. Interference and enrichment.
Cole CN, Baltimore D
J Mol Biol. 1973 May 25;76(3):345-61.
PMID: 4354478
Defective interfering particles of poliovirus. II. Nature of the defect.
Cole CN, Baltimore D
J Mol Biol. 1973 May 25;76(3):325-43.
PMID: 4354477
Defective interfering particles of poliovirus. I. Isolation and physical properties.
Cole CN, Smoler D, Wimmer E, Baltimore D
J Virol. 1971 Apr;7(4):478-85.
PMID: 4329564