Selected Publications
Croteau W, Jenkins MH, Ye S, Mullins DW, Brinckerhoff CE
Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma.
J Cell Physiol 2013 Apr; 228(4):773-80
PMID: 23001823
Schmucker AC, Wright JB, Cole MD, Brinckerhoff CE
Distal interleukin-1β (IL-1β) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression.
J Biol Chem 2012 Jan 6; 287(2):1189-97
PMID: 22102411
Eck SM, Blackburn JS, Schmucker AC, Burrage PS, Brinckerhoff CE
Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.
J Autoimmun 2009 Nov-Dec; 33(3-4):214-21
PMID: 19800199
Eck SM, Cote AL, Winkelman WD, Brinckerhoff CE
CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells.
Mol Cancer Res 2009 Jul; 7(7):1033-44
PMID: 19584257
Coon CI, Fiering S, Gaudet J, Wyatt CA, Brinckerhoff CE
Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.
Matrix Biol 2009 Sep; 28(7):425-31
PMID: 19577645
Petrella BL, Brinckerhoff CE
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Cancer Biol Ther 2009 Jul; 8(14):1389-401
PMID: 19483472
Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE
Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.
Arthritis Res Ther 2008; 10(6):R139
PMID: 19046432
Blackburn JS, Brinckerhoff CE
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.
Am J Pathol 2008 Dec; 173(6):1736-46
PMID: 18988801
Vincenti MP, Brinckerhoff CE
Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you?
J Cell Physiol 2007 Nov; 213(2):355-64
PMID: 17654499
Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE
Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand.
Arthritis Rheum 2007 Mar; 56(3):892-904
PMID: 17328062
Petrella BL, Brinckerhoff CE
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.
Mol Cancer 2006 Dec 1; 5:66
PMID: 17140440
Wyatt CA, Geoghegan JC, Brinckerhoff CE
Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth.
Cancer Res 2005 Dec 1; 65(23):11101-8
PMID: 16322260
Burrage PS, Mix KS, Brinckerhoff CE
Matrix metalloproteinases: role in arthritis.
Front Biosci 2006 Jan 1; 11:529-43
PMID: 16146751
Petrella BL, Lohi J, Brinckerhoff CE
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Oncogene 2005 Feb 3; 24(6):1043-52
PMID: 15592504
Mix KS, Sporn MB, Brinckerhoff CE, Eyre D, Schurman DJ
Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis.
Clin Orthop Relat Res 2004 Oct; (427 Suppl):S129-37
PMID: 15480055
Huntington JT, Shields JM, Der CJ, Wyatt CA, Benbow U, Slingluff CL Jr, Brinckerhoff CE
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
J Biol Chem 2004 Aug 6; 279(32):33168-76
PMID: 15184373
Mix KS, Coon CI, Rosen ED, Suh N, Sporn MB, Brinckerhoff CE
Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling.
Mol Pharmacol 2004 Feb; 65(2):309-18
PMID: 14742672
Tower GB, Coon CI, Brinckerhoff CE
The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells.
Breast Cancer Res Treat 2003 Nov; 82(2):75-82
PMID: 14692651
Tower GB, Coon CI, Belguise K, Chalbos D, Brinckerhoff CE
Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter.
Eur J Biochem 2003 Oct; 270(20):4216-25
PMID: 14519134
Wyatt CA, Coon CI, Gibson JJ, Brinckerhoff CE
Potential for the 2G single nucleotide polymorphism in the promoter of matrix metalloproteinase to enhance gene expression in normal stromal cells.
Cancer Res 2002 Dec 15; 62(24):7200-2
PMID: 12499258
Benbow U, Tower GB, Wyatt CA, Buttice G, Brinckerhoff CE
High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells.
J Cell Biochem 2002; 86(2):307-19
PMID: 12112000
Vincenti MP, Brinckerhoff CE
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Arthritis Res 2002; 4(3):157-64
PMID: 12010565
Tower GB, Coon CC, Benbow U, Vincenti MP, Brinckerhoff CE
Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells.
Biochim Biophys Acta 2002 Apr 24; 1586(3):265-74
PMID: 11997078
Brinckerhoff CE, Matrisian LM
Matrix metalloproteinases: a tail of a frog that became a prince.
Nat Rev Mol Cell Biol 2002 Mar; 3(3):207-14
PMID: 11994741
Mengshol JA, Mix KS, Brinckerhoff CE
Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?
Arthritis Rheum 2002 Jan; 46(1):13-20
PMID: 11817584
Tobin SW, Douville K, Benbow U, Brinckerhoff CE, Memoli VA, Arrick BA
Consequences of altered TGF-beta expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects.
Oncogene 2002 Jan 3; 21(1):108-18
PMID: 11791181